| Effector Protein ID: 296107557 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_02838 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2278001..2279197 [+] |
| Product | guanine nucleotide exchange protein |
| Effector type | Protein |
| Descripton | RalF |
| T4CP requirement | T4CP Depedent |
| Target/Effection | RalF mediates Legionella-containing vacuole (LCV) recruitment of Arf1 (ADP-ribosylation factor 1), which is a GTPase responsible for mediating vesicular transport between Golgi and endoplastic reticulum. RalF colocalizes with Arf1 and activates it on the LCV after bacterial internalization |
| UniProt ID | D5TEM2 |
| KEGG ID | lpa:lpa_02838 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Sec7 [PF01369], Evalue: 7.8e-56, Aligned region: 9..192 |
| Protein Sequence: 398 a.a. [Download] |
| >gi|296107557|ref|YP_003619258.1| guanine nucleotide exchange protein [Legionella pneumophila 2300/99 Alcoy] MHPEIEKAQREIIEAFNAKPKNGIKKIKEICGEYKISPNEEIAAFFHQQRKNLDLEAVGDYLSEPEAENQ QVLKAFTSQMDFNGQSFVEGLRIFLKTFKLPGEAQKIDRLVQSFSGAYSQQNPGVVSNADAAYLLAFQTI MLNTDLHNPSIPEKNKMTMDGLKRNLRGGNNGEDFDAKFLEELYSEIKAKPFELNFVKTSPGYELTSITL NKDSTFKKLDSFLHSTDVNINTVFPGIGDNVKTTVDQPKSWLSFFTGYKGTITLTDKQTSAQATIQVYTP NIFSKWLFGEQPRVIIQPGQTKESIDLAAKIAAGFSSPVKNFKATYDYEAGDLIKAYDNQKKLISTNKNT VIKGAMFRTPNAEQQETSKSATKTLNTDYDINEDTETIKDESKSSYKK |
| - |
| Nucleotide Sequence: 1197 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:2278001-2279197 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGCATCCAGAAATTGAAAAGGCACAAAGAGAGATTATTGAGGCTTTTAACGCCAAACCTAAAAATGGGA TAAAAAAAATAAAAGAAATATGTGGGGAATATAAAATTTCCCCGAATGAAGAGATTGCTGCTTTCTTTCA TCAACAAAGAAAAAATTTAGATTTAGAAGCGGTTGGCGATTATTTGAGTGAGCCAGAAGCAGAAAATCAG CAAGTATTAAAAGCTTTTACCAGTCAAATGGATTTCAATGGGCAGAGTTTTGTTGAGGGTTTAAGGATCT TTTTGAAAACATTTAAATTACCAGGAGAAGCTCAAAAAATTGACAGGTTAGTGCAAAGCTTTAGTGGCGC CTATTCCCAGCAAAATCCTGGTGTGGTTTCCAATGCGGATGCTGCCTATCTTTTAGCATTTCAAACCATT ATGCTTAATACTGATTTGCATAACCCAAGTATCCCTGAGAAAAATAAAATGACTATGGATGGACTCAAAA GAAATCTCAGAGGAGGTAATAATGGTGAAGATTTTGATGCCAAATTTTTAGAGGAACTATACAGTGAGAT TAAAGCCAAACCTTTTGAGTTGAATTTCGTTAAAACCAGCCCAGGATATGAACTTACTTCAATCACTCTC AATAAAGATTCTACCTTTAAAAAGCTGGATTCATTCTTGCATTCAACGGATGTAAACATCAATACCGTTT TTCCAGGAATAGGTGATAATGTTAAAACAACTGTAGATCAACCAAAATCATGGTTAAGTTTTTTTACCGG ATATAAGGGAACAATAACGTTAACGGATAAGCAAACATCCGCACAAGCTACTATCCAGGTTTACACTCCC AATATATTTTCAAAATGGCTATTTGGAGAACAACCGAGAGTAATAATACAACCTGGACAGACCAAAGAGT CAATCGATTTGGCAGCAAAAATAGCAGCTGGTTTTTCATCGCCAGTAAAAAATTTTAAAGCGACGTATGA TTATGAGGCAGGTGATTTAATAAAAGCATATGACAACCAGAAAAAACTCATTTCGACCAATAAAAATACG GTAATTAAGGGGGCTATGTTCAGAACACCAAACGCTGAACAACAAGAAACTTCAAAATCTGCAACAAAAA CGCTTAATACTGACTATGATATAAACGAGGATACAGAGACTATAAAAGATGAAAGTAAATCGAGTTATAA GAAATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |