| Effector Protein ID: 296107062 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_02161 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1699023..1700600 [+] |
| Product | serine/threonine-protein kinase |
| Effector type | Protein |
| Descripton | LegK1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | The canonical serine/threonine kinase activity of LegK1 is essential for potent activation of the NF-kB pathway. LegK1 mimics host IKK and directly phosphorylates the Ser32 and Ser36 residues of the inhibitory IkBa protein, leading to IkBa ubiquitination/degradation and subsequent nuclear translocation of p65. (Ge and Shao, 2011) |
| UniProt ID | D5TD76 |
| KEGG ID | lpa:lpa_02161 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pkinase [PF00069], Evalue: 4.3e-27, Aligned region: 82..358 Pkinase_Tyr [PF07714], Evalue: 2.5e-14, Aligned region: 82..286 |
| Protein Sequence: 525 a.a. [Download] |
| >gi|296107062|ref|YP_003618762.1| serine/threonine-protein kinase [Legionella pneumophila 2300/99 Alcoy] MFFSVDAANLQNLQITNRKAFAALESYLNDNDSPGAWNNNQGYKYTHKDVTYCFSFNQSLVRRPRKSDQK KHTFEIFDPNKNPLGKGAYGIVYPILGAIQFEFGTAIKRPPKNKLVKIQNHSERDQSHSVLREYQGLLQS GHIAVKPPIFVENKESKFSYLIMEKAEGIVLEKFLNPVKRLDLSEEVPELNLINRIEITFAILKAIKEQV TDKHLIHRDIKPGNIIIDFSKSPPIAKVIDFGFVLRASEQDYRRCGTRAYRAPESFNTQALYTAKADVWS TGRILSYLWGDKYTNYYISRDKGLDYVIEKSRNELLFSDPELELYLTKEDKSKIRSCLSAMLIVDPEERG SIDKAIKQFSQIDFEKYKRLKRSTNFEIDLTDNDIKLRKQLNSIHLHLITLQGKEKDLRDRACFDAANAM SQLVSKLSTYTNYLEKNPDPFLIKRYKECCIAEIDLANLALQNHRDALWLVAELSTAILLLGIGYLFAFG INYYYTGRLGLFSQTRSEKLVEEMKSSVLGIAVGN |
| - |
| Nucleotide Sequence: 1578 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:1699023-1700600 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGTTTTTTTCCGTTGATGCAGCTAATCTCCAAAATTTACAAATTACAAATCGAAAAGCTTTTGCAGCGT TGGAGAGTTATCTGAATGATAATGATTCACCAGGTGCCTGGAATAATAATCAAGGATACAAATATACTCA TAAGGATGTTACTTATTGCTTCTCATTTAATCAATCCTTAGTAAGACGCCCAAGAAAATCGGATCAAAAA AAACATACATTTGAAATTTTTGACCCTAATAAGAACCCTTTAGGCAAGGGAGCGTACGGTATTGTCTATC CCATTTTAGGTGCAATTCAGTTTGAATTTGGAACCGCAATTAAAAGACCACCAAAGAATAAATTAGTTAA AATACAAAACCATAGTGAACGCGATCAAAGTCATTCTGTACTACGTGAATATCAAGGGCTTCTTCAATCA GGGCATATAGCGGTTAAACCGCCAATATTTGTAGAAAACAAAGAGAGTAAATTCAGTTACTTGATTATGG AAAAAGCGGAGGGTATCGTTTTAGAGAAGTTTCTAAATCCCGTTAAGCGGCTTGATTTGTCTGAAGAGGT ACCCGAGCTTAATCTTATTAATCGGATTGAGATTACTTTTGCCATTTTAAAAGCAATTAAAGAACAGGTG ACGGATAAGCATTTGATTCATCGAGATATAAAACCAGGAAATATTATAATCGATTTTAGCAAGTCACCTC CGATAGCTAAAGTAATCGATTTTGGTTTTGTGCTTAGGGCGTCAGAACAGGATTACCGTCGTTGTGGAAC CCGAGCATACAGAGCGCCCGAATCTTTCAATACCCAGGCATTGTACACAGCAAAAGCTGATGTTTGGTCA ACAGGCAGGATATTAAGTTATTTGTGGGGAGATAAATATACTAATTACTATATCTCTCGTGATAAGGGTT TGGACTACGTGATTGAGAAGTCAAGAAACGAACTACTCTTCTCTGACCCAGAATTGGAACTCTATTTAAC CAAGGAAGATAAAAGTAAAATCAGATCGTGCCTAAGCGCAATGCTTATAGTTGACCCTGAGGAAAGAGGA TCTATAGATAAGGCTATCAAACAGTTTTCCCAAATTGATTTTGAAAAATATAAAAGATTAAAGCGCTCTA CAAATTTTGAAATTGATTTAACAGATAATGATATTAAATTAAGAAAACAGCTCAATTCAATTCACCTGCA TTTGATTACCCTACAGGGCAAAGAAAAAGATTTGCGTGATAGAGCATGTTTTGATGCAGCGAATGCAATG AGCCAATTGGTTAGTAAGCTCTCTACCTACACCAATTATCTTGAAAAAAATCCAGATCCATTTTTAATAA AACGTTATAAAGAGTGCTGCATCGCAGAAATAGATTTAGCTAATTTGGCTTTGCAAAATCACCGAGATGC TTTATGGTTGGTGGCTGAGTTATCAACTGCTATCCTTTTGCTTGGTATAGGGTATTTATTTGCTTTTGGG ATAAATTATTACTACACAGGTCGCCTGGGATTATTTTCTCAAACCAGGTCTGAGAAATTGGTGGAAGAAA TGAAAAGTTCGGTGTTAGGTATTGCGGTTGGAAATTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |