| Effector Protein ID: 296106283 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | arp |
| Locus tag | lpa_01082 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 851943..854780 [+] |
| Product | Ankyrin repeat protein |
| Effector type | Protein |
| Descripton | AnkN/ankX legA8 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkX modified both Rab1 and Rab35 by cAMP(Fic) domain-dependent manner (Mukherjee, et al, 2011) |
| UniProt ID | D5TA62 |
| KEGG ID | lpa:lpa_01082 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 3.4e-47, Aligned region: 368..439 Ank_2 [PF12796], Evalue: 3.4e-47, Aligned region: 441..523 Ank_2 [PF12796], Evalue: 3.4e-47, Aligned region: 557..628 Ank_2 [PF12796], Evalue: 3.4e-47, Aligned region: 639..708 Ank_4 [PF13637], Evalue: 8.6e-35, Aligned region: 390..436 Ank [PF00023], Evalue: 6.8e-33, Aligned region: 388..418 Ank [PF00023], Evalue: 6.8e-33, Aligned region: 420..437 Ank [PF00023], Evalue: 6.8e-33, Aligned region: 586..615 Ank_5 [PF13857], Evalue: 4.9e-32, Aligned region: 388..428 Ank_5 [PF13857], Evalue: 4.9e-32, Aligned region: 584..624 Fic [PF02661], Evalue: 1.4e-07, Aligned region: 173..234 |
| Protein Sequence: 945 a.a. [Download] |
| >gi|296106283|ref|YP_003617983.1| Ankyrin repeat protein [Legionella pneumophila 2300/99 Alcoy] MPNLPGLYFLQAYPREEIWRLFVDGRFWSKENGWRGYESREPGCLNAALESLCSIALQVEKSGEEFELSV DLIKRIHKKCGKKVEELQEKNPGELRTDEPVSFGIPAGRASIKGIEEFLSLVFLTEGEAEFGPGKAGPFG PRFDKNYFKNLNPEQIPDLAKQIYFDMCKYGHSNTNHFYLAVMKNVDVYLEKITQSYNQEIKTAETLDEK LKIIVKHIRMYEVLHPFRDANGRTFVNNLLNILLMQQGLPPATFYEPNVFDLYSAEELVVVVKEAIFNTV EIIEQSKRKTPITLYGYHSSLEEQTKFRDMLDSPAYEKIKHMDFSDLNPEKLHRKTQKCLSSLNEQYPLH RGAIYLSDPGEIKLLLSNRNESQINQQIEQGAPPIYVGKTPAHLAVISGNMAMIDELIAKKADLSLQDYD GKTALHYAAECGNMQIMGKILKVVLSQEDAIKVLNIKDNHGKTAFHYAAEFGTPELISALTTTEVIQINE PDNSGSSAITLAYKNHKLKIFDELLNSGADISDELLDAIWARKDKETLGKIIAKNEKILLNKEAFRIAIS LGSVSLVKKFLRAGVDIDIPLTKDKATPLMLSINSGNPKLVSYLLKKGANTRLTDTSGNSVLHYVFYSKA ENREALANIITEKDKKLINQPNTNGNPPLYNAVVVNDLKMATILLEMGARVDFEDRLGNNILHSAMRRCD LPIILDIVKKDSTLLHNRNSERRNPFHQALHEMHTFPSSKETEEIHFMNLSDLLLKEGVDLNKKDIKGKT ILDIALSKQYFHLCVKLMKAGAHTNISSPSKFLKNSDANSILERPFKFKNDLKKELDDNPLIAMAQINDL YVQIKNNRIRTPTGYAPKEGVSFFKGKSSDAKAHDEVLSVLKELYDSKLTEMLGNLPGEGLEEIKRSQKF FDGELKLLIKNQDISRKVDKKSIQEAVGTSLKLKW |
| - |
| Nucleotide Sequence: 2838 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:851943-854780 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGCCAAATCTACCTGGATTATATTTTCTTCAAGCCTATCCACGCGAAGAAATATGGAGATTATTTGTTG ATGGACGCTTCTGGTCAAAAGAAAATGGATGGAGAGGCTATGAGTCGCGAGAGCCAGGATGCCTTAACGC CGCTCTGGAGAGTTTATGTTCTATTGCATTGCAAGTTGAGAAATCAGGAGAGGAATTTGAATTAAGCGTT GATTTAATAAAGAGGATACACAAGAAGTGTGGAAAAAAGGTGGAGGAATTACAGGAAAAAAATCCAGGTG AACTCAGAACAGATGAACCTGTTTCATTTGGCATTCCAGCTGGCCGGGCCTCGATTAAGGGTATTGAAGA ATTCCTGAGCCTGGTATTTCTTACAGAAGGCGAAGCTGAATTTGGCCCAGGCAAAGCAGGTCCATTTGGC CCACGCTTTGATAAGAATTATTTTAAAAATCTGAATCCAGAACAAATACCGGATCTTGCCAAGCAAATCT ATTTCGATATGTGCAAATATGGGCATAGTAATACCAATCACTTTTATCTTGCAGTAATGAAAAATGTGGA TGTTTACCTGGAAAAAATTACCCAATCTTACAACCAGGAAATAAAAACCGCTGAAACTCTTGATGAAAAA CTTAAAATTATCGTTAAGCATATTCGAATGTACGAAGTATTGCACCCTTTTCGAGATGCCAATGGCCGTA CCTTTGTCAATAATTTATTAAATATTCTTTTAATGCAACAAGGTTTACCGCCAGCGACATTTTACGAACC TAATGTCTTTGATTTATATAGCGCTGAGGAATTAGTTGTTGTTGTGAAGGAGGCAATTTTTAATACGGTA GAAATTATTGAACAAAGTAAAAGAAAGACTCCCATTACTTTATATGGATATCATTCAAGCTTGGAAGAGC AAACCAAATTTCGGGACATGCTGGATAGCCCAGCGTATGAAAAAATCAAACATATGGATTTTTCAGATTT AAACCCTGAGAAACTGCATCGGAAGACTCAAAAATGTTTATCATCATTAAATGAGCAATATCCATTACAC AGAGGTGCAATCTATCTTAGTGATCCCGGTGAGATAAAATTATTATTGTCAAATCGCAATGAATCCCAGA TTAATCAGCAGATAGAGCAAGGAGCACCGCCTATTTATGTCGGTAAAACTCCTGCTCATTTGGCTGTCAT ATCAGGAAATATGGCAATGATTGATGAGCTTATCGCAAAAAAAGCGGATTTATCTCTTCAGGATTATGAT GGAAAAACCGCTCTTCACTATGCTGCAGAGTGTGGAAATATGCAAATTATGGGAAAAATACTAAAAGTTG TGCTAAGCCAGGAAGATGCCATCAAAGTACTGAATATCAAGGATAATCATGGCAAAACAGCATTCCATTA TGCTGCTGAGTTTGGAACCCCGGAATTAATATCAGCCTTGACAACCACAGAGGTTATTCAGATTAATGAA CCGGATAACAGCGGTTCTTCAGCAATCACTTTGGCATATAAAAATCATAAATTGAAAATTTTCGATGAAC TATTAAATTCCGGTGCTGATATCAGTGATGAGCTTTTGGACGCGATATGGGCTCGGAAGGATAAAGAAAC ATTAGGTAAAATAATTGCCAAAAATGAGAAAATTCTTTTGAATAAAGAAGCCTTCAGGATAGCTATTTCT TTAGGAAGTGTCAGTCTGGTTAAAAAATTTTTACGCGCCGGGGTCGATATTGATATACCCTTAACTAAAG ATAAAGCAACACCGCTAATGTTATCTATAAATTCCGGTAATCCCAAATTGGTCAGTTATTTATTGAAAAA GGGAGCTAATACACGTTTAACCGATACCAGTGGTAATTCTGTCCTGCATTATGTTTTTTATTCAAAGGCA GAAAACAGGGAAGCTTTAGCAAATATTATAACTGAGAAAGATAAGAAATTAATTAATCAGCCAAATACTA ATGGAAATCCACCTCTTTATAATGCTGTGGTAGTTAATGATTTGAAAATGGCAACAATTTTATTAGAAAT GGGGGCAAGGGTCGATTTCGAAGACAGGCTGGGAAATAATATTTTGCATAGTGCCATGAGAAGATGTGAT TTGCCGATTATATTGGATATTGTCAAGAAAGATAGCACCTTACTTCATAATAGAAACTCTGAAAGAAGAA ATCCTTTTCATCAGGCATTGCATGAGATGCATACGTTTCCATCCTCAAAAGAAACCGAAGAAATACACTT CATGAATTTAAGTGATTTACTTTTAAAAGAAGGAGTCGATTTAAATAAAAAAGATATTAAAGGAAAAACA ATATTAGATATCGCATTATCCAAGCAGTATTTTCATTTATGTGTCAAACTGATGAAAGCAGGTGCCCATA CCAATATATCTTCTCCATCAAAATTTCTTAAAAACTCCGATGCCAATTCTATTTTGGAACGTCCTTTTAA ATTTAAGAACGATTTAAAAAAAGAGCTCGATGATAATCCGCTAATTGCTATGGCACAAATTAATGATTTG TACGTCCAAATCAAAAATAACAGGATTAGGACTCCTACAGGTTATGCCCCGAAAGAAGGAGTATCCTTTT TTAAAGGAAAATCAAGCGATGCCAAAGCACATGATGAGGTTTTGTCTGTTTTAAAGGAACTCTACGATAG TAAACTCACAGAGATGCTCGGTAATCTTCCTGGTGAAGGATTAGAAGAAATCAAAAGAAGCCAGAAATTT TTTGACGGCGAACTAAAATTATTAATTAAAAACCAGGACATTTCGAGGAAAGTCGATAAAAAGTCTATTC AGGAAGCAGTTGGTACATCCTTGAAATTAAAATGGTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |