| Effector Protein ID: 296105926 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_00597 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 463931..468220 [-] |
| Product | SdhA, GRIP coiled-coil protein GCC185 |
| Effector type | Protein |
| Descripton | SdhA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SdhA is critical for intracellular growth and functions to prevent host cell death. SdhA also functions to inhibit Legionella infection-induced type I interferon response. Besides, SdhA prevente bacterial DNA release and AIM2 inflammasome activation. |
| UniProt ID | D5T802 |
| KEGG ID | lpa:lpa_00597 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1429 a.a. [Download] |
| >gi|296105926|ref|YP_003617626.1| SdhA, GRIP coiled-coil protein GCC185 [Legionella pneumophila 2300/99 Alcoy] MISEKIKLLESFKQNQFSKLIEKINSKILATLKSGHFNPRLAPYLEKMNKDGVPFTDFDLDPENISQIKK LINALYHARLAFLDLENIDIGNIKRTIPDLKLLYSNTIHQAYQAGYLITNLDVDLQEMFKEEIDLILPVI GKLQAFAGEHQECTKHLAESLKDFPISYKAGEVTGIALEQMQPRTGDWDYQFLTQFSAVLPGYIEKLTQY IQQYSSQIKEKEPTLNNEKLEELQNASLKLLNDLEHLKGNDFFISLKVLKYIHIIRNIITLATSSVEQMG HFSDSSQDVIRDNLAQLKYVVLPTLFGLVDKIEDNAMLKPGTLSIPLMEKIKPLYQLLIYYASKPVNFKE KGEELLSIEDSRFLALRLERTYQRIDEANKALFKIQKAQEALDNFYKILDTPPYNKQPIHQLPKEIKNQL ITYYKIISPYMMDVNPDLNILLIDSFQGPESWSSYLKKPWRWLRGTLPADHASFVLAQKEALQTLISKKK ATQQFHIELNRDLIESVHKQTNLVLFPYSEKTNVFLLDETKALNPANGATDKLKFRPEKGHNILVNPEDL TSEQALDLYQWYRNKREKFRVASKAYNEFITLLKKQTKTIAETEGRILHLNNLDKETKTRCRNLYNIFQP YFIDGIPPELRASAISFDKFLVHSFSNESSTYDAPAVDLFEKLDEHFQIYFTEIDLQWGKKSNQYLKWAQ EKFASENNSTELEHDEKLESRAHHLIKHTNFSKCIHEFRTELNQVISFFNNAMRAQLKQQPNGIPYPELQ DQNKELAQSEQVVAIKRIFNSLYHVEKIVVELEKLDTRSYESIYVYHLIQAYDHINEIKKLALKLAVDPH FKLIASELLEKAQTLIATIQEHSDAYQVSPLEVPYNQDIKYNALWYTLNAFYISPKHIRSLRNTNYLTTE ELNDLHLKAKKATVTVENIIKSSNSYFKLFLQTPAMYSLYREMTNKLNEFISTSHDAVMNNLDQFRSKIF TPMLMEADAWEDKLGLVPGTISGPLKTITDEYYKGLLHPLALHSKAHIRMICDKTPIDQRIKTTNKKLEN ATQHLDKIEKNYKHIIKLYEIIKTKGGKTTDDELIETYKKALYKLVKLQKRLPQNTDHDPKDYELDTLLN SELKEYEPKLTLIKPLIISSYHHYEGLKATYLMKANTAREKLSYLKELRSTQEQEDLLYIEEYTTESFNK QLDAFCNRHIGLQYTDKEYRTKLREYLLTFKESIIQRSKSAEDINLTIKNLLKEKIKNFERDNFEKYYHL DAVRVALAQFKNYFSLSTAAIEQNNSTFESEETLAKKTELINKLVDISEDGTLTPKERVDQISFHVKNPN FERIIMDYKQESYFSFTYLKQCILSLLEALCLYTPERRKLFNNLESSVKTQPKINELTKRFGLFAGNESA ISTESRAITPVSSVENNGTIELNQLAPST |
| - |
| Nucleotide Sequence: 4290 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:c468220-463931 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGATTTCAGAAAAGATCAAGCTTTTAGAATCCTTTAAGCAAAACCAATTCTCTAAATTAATTGAAAAAA TTAATTCAAAAATCCTTGCGACTTTAAAAAGCGGACATTTCAACCCCAGACTAGCCCCCTACTTGGAAAA AATGAATAAAGACGGGGTTCCATTCACCGATTTTGATCTTGACCCGGAAAATATTTCTCAAATCAAGAAA CTCATTAACGCCCTTTACCATGCCCGTTTAGCTTTTCTGGATTTAGAGAATATTGACATAGGGAACATCA AACGAACTATCCCTGATCTCAAATTACTTTACAGCAACACGATTCACCAGGCCTATCAAGCCGGTTATCT AATCACTAACCTGGATGTTGATTTGCAGGAAATGTTCAAGGAAGAGATTGATCTTATTCTTCCTGTCATT GGAAAATTACAAGCTTTTGCTGGTGAACACCAGGAATGCACCAAGCATTTGGCAGAATCTTTGAAGGATT TTCCTATAAGCTATAAAGCAGGAGAAGTTACAGGCATTGCCTTAGAGCAAATGCAACCGAGAACAGGAGA TTGGGATTACCAATTCCTCACTCAATTCAGTGCCGTATTACCTGGTTATATAGAAAAATTAACTCAATAC ATTCAACAATACTCTTCGCAAATCAAAGAAAAAGAGCCTACTCTAAATAATGAAAAGCTGGAAGAGTTAC AAAACGCATCATTAAAATTACTAAATGACCTGGAACATCTGAAAGGGAATGACTTTTTTATATCCCTTAA AGTTTTAAAATACATTCACATTATCCGTAATATCATCACATTGGCGACAAGCTCTGTTGAACAAATGGGA CATTTCAGCGATTCATCTCAGGATGTCATTCGTGATAATTTGGCTCAATTAAAATACGTTGTATTACCTA CTTTATTTGGGTTAGTGGATAAAATTGAAGACAATGCCATGCTGAAGCCTGGTACACTGTCTATTCCGTT AATGGAAAAAATCAAACCTCTATACCAGCTTTTAATTTATTACGCATCCAAACCCGTCAATTTCAAAGAA AAAGGAGAAGAGTTACTCAGTATAGAGGACTCCCGTTTTCTCGCTTTAAGACTGGAAAGAACATATCAAC GAATTGATGAAGCTAACAAAGCCCTTTTTAAAATTCAAAAAGCGCAAGAAGCTCTGGATAATTTTTACAA AATATTGGACACCCCCCCCTATAATAAGCAACCCATACATCAATTACCGAAAGAAATTAAAAACCAACTG ATTACATATTACAAAATAATCAGTCCTTATATGATGGATGTGAATCCTGATCTCAATATTTTGTTGATCG ATAGTTTTCAGGGCCCGGAATCCTGGTCTTCTTATTTAAAGAAGCCGTGGCGTTGGTTAAGAGGCACTCT TCCAGCCGATCACGCCAGTTTTGTTTTAGCGCAAAAGGAAGCATTACAAACTTTAATTAGCAAAAAGAAA GCCACTCAACAATTTCATATCGAATTGAATAGAGACCTTATCGAATCTGTTCACAAACAAACAAATCTGG TTTTATTCCCTTATAGTGAAAAAACGAATGTCTTTCTTCTAGATGAGACAAAAGCACTAAACCCTGCTAA TGGCGCTACGGACAAACTAAAATTCAGGCCAGAGAAGGGACATAATATACTGGTTAATCCTGAAGATTTA ACATCTGAACAGGCTCTTGACCTCTATCAATGGTATAGAAACAAACGTGAGAAATTCAGAGTTGCCAGCA AAGCATATAATGAATTTATTACCTTATTAAAAAAGCAAACCAAGACAATCGCTGAAACGGAAGGCAGGAT TCTCCATTTAAATAATCTTGATAAAGAGACCAAAACTCGCTGCCGTAATTTATATAATATATTTCAACCT TATTTTATCGATGGGATACCTCCTGAACTCAGAGCTTCCGCAATAAGTTTTGACAAATTTTTGGTTCATT CCTTTTCTAATGAGTCATCCACCTATGATGCCCCGGCAGTTGACCTGTTTGAAAAACTGGATGAACATTT TCAAATTTATTTTACAGAAATTGATTTACAATGGGGTAAAAAGAGTAATCAATATTTAAAATGGGCCCAG GAAAAATTTGCCAGTGAAAATAACTCAACCGAACTTGAACATGATGAAAAACTGGAAAGCAGAGCCCATC ATTTAATTAAACATACCAATTTCTCTAAATGCATACATGAGTTTAGAACGGAGCTTAATCAAGTCATTTC GTTTTTTAATAATGCGATGAGGGCGCAATTAAAACAACAACCCAATGGAATACCTTACCCTGAATTGCAA GATCAAAATAAAGAGCTTGCCCAGAGTGAACAGGTTGTTGCGATAAAACGCATATTCAATAGCCTCTATC ATGTTGAAAAGATTGTTGTTGAACTGGAAAAACTGGACACCAGAAGTTACGAAAGCATTTATGTCTATCA TTTAATACAAGCCTATGATCACATTAATGAAATTAAGAAATTAGCGCTAAAACTCGCTGTGGATCCTCAT TTTAAGCTCATAGCAAGCGAGTTACTGGAAAAAGCGCAAACTCTTATTGCAACAATACAAGAACACAGTG ATGCGTATCAGGTATCCCCGTTAGAAGTACCTTATAACCAGGATATTAAATACAATGCTCTTTGGTATAC ACTCAATGCTTTTTATATTTCACCAAAACACATTAGAAGTTTAAGAAATACCAACTATCTCACGACAGAA GAACTCAACGACTTACACTTAAAGGCAAAAAAAGCAACCGTTACTGTAGAAAATATCATTAAAAGTTCAA ACTCCTATTTCAAATTATTCTTACAAACGCCTGCCATGTATTCTCTCTATAGAGAAATGACGAACAAACT GAATGAATTTATTAGCACATCACATGACGCCGTAATGAATAATCTGGATCAATTCCGCTCCAAGATTTTT ACACCCATGCTGATGGAAGCGGACGCATGGGAAGATAAATTAGGCTTGGTACCAGGTACTATCTCAGGAC CATTAAAAACAATAACGGATGAATATTATAAAGGCCTGTTACATCCTTTAGCGCTGCATTCCAAAGCACA TATTCGCATGATATGTGATAAAACACCAATAGATCAAAGAATAAAAACAACGAATAAAAAACTCGAAAAT GCAACACAACATTTGGATAAAATAGAAAAAAATTATAAACATATCATCAAGCTATATGAAATTATCAAAA CAAAAGGCGGCAAAACCACTGATGATGAATTAATCGAAACTTATAAAAAAGCTCTGTACAAATTGGTAAA ATTACAAAAGCGATTACCCCAGAATACAGATCATGATCCTAAAGATTATGAATTAGACACTCTTTTAAAT TCAGAGCTGAAAGAGTATGAACCTAAATTAACGCTCATTAAGCCTCTCATTATCTCAAGCTACCATCATT ATGAAGGCCTAAAAGCCACTTATCTTATGAAAGCAAATACTGCCAGAGAAAAGTTGAGTTATCTTAAAGA GTTACGATCGACTCAGGAACAAGAAGATCTCCTTTATATAGAAGAATACACTACAGAATCATTTAATAAA CAATTAGATGCTTTCTGCAACCGTCATATCGGTTTACAATACACTGACAAGGAATATCGCACAAAACTTA GAGAATATTTACTGACATTCAAAGAAAGTATTATTCAACGCTCAAAATCCGCAGAAGATATTAATTTAAC TATAAAAAATTTGCTAAAGGAAAAAATTAAAAATTTTGAAAGAGATAATTTTGAAAAATATTATCATCTT GATGCAGTAAGAGTTGCTTTAGCTCAATTTAAAAACTACTTTAGTCTTTCTACCGCTGCCATCGAGCAAA ATAATTCGACATTTGAAAGCGAAGAGACACTGGCGAAAAAGACAGAGCTCATTAATAAACTGGTTGATAT CAGTGAAGATGGAACCCTTACGCCAAAAGAGCGTGTCGACCAAATATCTTTCCATGTTAAAAATCCTAAT TTTGAAAGAATCATCATGGATTACAAACAGGAAAGCTACTTTAGCTTTACCTATTTAAAACAATGCATCT TATCCTTATTGGAAGCGCTTTGCCTGTACACTCCGGAGAGAAGAAAACTATTTAATAATTTGGAAAGCTC TGTAAAAACCCAGCCTAAAATCAATGAACTGACCAAACGATTTGGATTATTTGCTGGCAATGAGTCAGCT ATCTCTACTGAATCCAGGGCAATTACCCCAGTTTCTTCTGTTGAAAATAATGGAACAATTGAATTAAACC AATTAGCGCCATCAACATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |