| Effector Protein ID: 296105836 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_00479 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 376080..377537 [+] |
| Product | Ras GEF |
| Effector type | Protein |
| Descripton | LegG2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegG2, which has a Ras GEF domain, is believed to be involved in GDP-to-GTP exchange in Ras GTP-binding protein (de Felipe, et al. 2005) |
| UniProt ID | D5T7C9 |
| KEGG ID | lpa:lpa_00479 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | RasGEF [PF00617], Evalue: 2e-09, Aligned region: 95..256 |
| Protein Sequence: 485 a.a. [Download] |
| >gi|296105836|ref|YP_003617536.1| Ras GEF [Legionella pneumophila 2300/99 Alcoy] MIGMRAEQCNLKSFFVHSLKNKSNLLPLIACFNNREINMPKILDSNAYREMENELNNLFEQIYKHGKNDR TAITLQVQQFLDNLSESIRDHSRLLLTNIAREELIYFKEKKPGDSREKFQNIDKMSDYFNNLSALINFSV MQQEDPTLRVFYYDMYIQLMNFCYLKGDLFGAGAIYTGLIANNLPNSIDRKQLSSESRLIFKDCEEKFKR LFNLSTTYNEHTNLKRQFKTALIPALPSLLTVQIYTKDAYDNSVSDFERVQEKLRQLDIEHNRFLNQLQN DHSTWSKAYYDYMSNVYLPQSIFEYTTLLREYEELITTHGGPIAKQFHEDKNSEHLVSFVESTLLENQSD LKLSPFQNERIVEMLSEIDVVKSECSSPDVFDDISWKLREMNCTLVKAKSIGDYTSKIFANLDTPYMEEN TDEDPKPVLVEELQTDDVYQLHHSGMKLIRELEQAIEDHKRRLFIIVQVRQTMVSLRKPEGGGGI |
| - |
| Nucleotide Sequence: 1458 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:376080-377537 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome GTGATTGGAATGCGTGCTGAACAATGCAACTTAAAATCATTTTTTGTCCACAGTTTGAAAAATAAAAGTA ATTTATTGCCATTAATTGCATGTTTTAATAATAGAGAAATCAATATGCCTAAAATTTTAGATAGCAATGC ATATCGCGAGATGGAAAATGAGCTCAATAATCTTTTCGAGCAAATTTATAAGCATGGTAAAAATGACAGA ACCGCGATTACATTACAAGTTCAGCAATTTTTAGATAATTTGAGCGAATCCATTAGGGATCATTCCCGCT TATTGCTTACCAATATTGCCAGAGAAGAACTCATTTATTTTAAGGAAAAGAAACCTGGAGATTCGCGAGA GAAATTTCAAAATATCGATAAGATGAGTGATTACTTTAACAATTTATCTGCATTGATTAATTTCTCTGTA ATGCAACAAGAAGATCCTACTCTGCGGGTTTTTTATTATGATATGTATATTCAACTAATGAATTTTTGCT ATCTTAAAGGGGATTTGTTTGGAGCGGGTGCAATTTATACGGGTTTAATAGCTAATAACCTCCCTAACTC TATTGATCGGAAGCAATTGAGCTCCGAGAGTCGCCTGATTTTTAAAGATTGTGAAGAAAAATTTAAGCGA TTATTCAATCTCTCAACTACATACAATGAACACACTAATTTAAAAAGACAATTCAAAACTGCTTTGATAC CCGCATTACCGTCACTTCTCACGGTTCAGATATATACTAAAGACGCTTACGATAACTCTGTCAGCGATTT TGAAAGAGTTCAGGAGAAGTTACGTCAGTTGGATATAGAACATAATCGGTTTCTTAATCAATTACAAAAT GACCATTCAACCTGGTCTAAAGCTTATTATGATTATATGAGTAATGTTTATCTCCCGCAAAGTATATTCG AATACACGACTCTTTTAAGAGAGTATGAAGAACTTATCACAACGCATGGTGGCCCTATTGCGAAACAGTT TCATGAGGATAAGAATTCAGAACATCTGGTAAGCTTTGTTGAATCGACGCTATTAGAAAATCAATCAGAT CTCAAATTATCTCCTTTTCAAAATGAGAGAATTGTTGAAATGCTTTCCGAGATTGACGTGGTAAAAAGTG AGTGCTCAAGCCCAGATGTGTTTGATGACATCTCCTGGAAGTTGAGAGAAATGAATTGTACTTTGGTAAA AGCCAAATCTATTGGTGATTATACTTCCAAAATTTTTGCAAATCTTGATACTCCATACATGGAAGAAAAT ACGGATGAAGATCCGAAACCAGTGCTTGTAGAAGAACTGCAAACGGATGATGTGTACCAACTTCACCATA GTGGTATGAAATTGATACGTGAGCTCGAACAGGCTATAGAAGATCATAAACGAAGGTTATTTATCATTGT TCAGGTGAGGCAAACTATGGTTTCTTTAAGGAAGCCAGAAGGAGGGGGAGGCATTTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |