| Effector Protein ID: 296105835 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | sdbA |
| Locus tag | lpa_00477 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 372650..376000 [+] |
| Product | SdbA protein, putative substrate of the Dot/Icm system |
| Effector type | Protein |
| Descripton | SdbA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SdbA has been proved to contribute to sustained NF-kappaB activation in A549 epithelial cells, and are essential for L. pneumophila replication (Bartfeld, et al, 2009) |
| UniProt ID | D5T7C8 |
| KEGG ID | lpa:lpa_00477 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1116 a.a. [Download] |
| >gi|296105835|ref|YP_003617535.1| SdbA protein, putative substrate of the Dot/Icm system [Legionella pneumophila 2300/99 Alcoy] MHKKYNYYSLEKEKKTFWQHILDILKAPFRLPGWVVSFFLARNITHVALNPNNIPQQRLIHLTKTSNRPE DDIVVINFKKRPPHKWFNDTLIKIANTIAALPFVTPRLRTRLHYDNENDINHVNKLLAEIDALVQGKSKQ KYCKGRAFDWSKIHLKGLEFLDPKMRGYVYEQLHEKYGYVSYTTKREPNIEFFTLKTPDGSELDSVQVTG EDEEKKPMRERKFIITCIARDQNFINWIKDLNYTAKNLGATAISFNYRGVDYSRGLVWTENNLVDDILAQ VQRLISLGADPKNICLDGMCIGGAVATIAAAKLHEKGMKVKLNNERSFTSLSSLVFGFIVPELQTANWWS PLTYGRFLLAGVVYALLTPLIWLAGWPVDVTKAWNRIPAQDKMYSVVRDKDNGLYDGVIHDHFCSIASLV DSQINSILYKLSTDQLLTEEEKQILCDDQLSHHFKPSQSVLKNPKYKGPHFISRQDLVAELGHREEYTNH DYFLDRLREKFQLDRTIRPVALAEDGEKDIDGIPPQLSNHKERPLIIASSGGTGHISATHGIINDLQSKT DNVVITQHHAELYKNKPFSITSVLIRIGVWLTSLPVLEDILKGVMRFIGYPVLPSSSIFWDQMSKIQQSE TKKENGIETGRTRPYVDMLLDIYPEGYEYTAFNNATHLTSSIEDIQTMISFKGHVEEDNRNIVYQNILQR LMHAAKQSTPYTRLISTQALSLGAICDAVKYYNTVFLPVYNAERGTSYQPITIDQYMTDLPSLGCIHFMN NLEELTSEQRQLMEIHAVNMSEPFKEAHFGKEQGFKAVHNIDPRNNPMIRNAFKDLSLTKYLDKTQSFDL HFNVYKKEKQNALPVLNGKEKITIKPHAKIASIMIGSLAANASADYAQYLLNQGYDHIFLFGGLNDSIAA RIDQIINSYPDSRHDEIRKKIILLGNQSDVEMAPIMTRSNCVVIRGGGLSVMEQMAMPIMDEKIVLLHHE DNEEGPLTSGLSWEDGNADKLIEYLSEKGAYAKKTSPGLCSGHLNEAEKDFEKKYITQLKSKGTKEKVDL TIPQQKKPPLKKEWGRKTGYTELGHVLSHQHRFFETIPEVREPFCSKEDLHHHELSSQSLVSVTVG |
| - |
| Nucleotide Sequence: 3351 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:372650-376000 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGCATAAAAAATACAACTACTACAGTCTTGAAAAAGAAAAAAAAACATTCTGGCAACATATACTGGATA TTCTGAAGGCCCCATTTAGGCTACCTGGTTGGGTCGTTTCTTTTTTCTTGGCACGAAATATTACTCATGT GGCATTAAATCCTAATAATATTCCGCAACAACGTTTAATACATCTTACTAAAACAAGCAATCGTCCAGAG GATGATATTGTTGTCATTAATTTCAAAAAACGGCCGCCTCACAAATGGTTTAATGACACGCTGATTAAAA TAGCCAATACGATTGCGGCTCTTCCTTTTGTAACACCAAGATTACGTACAAGATTACATTACGATAATGA GAATGACATCAATCATGTGAACAAGTTGCTTGCCGAGATCGATGCGCTTGTTCAGGGCAAATCAAAACAA AAGTATTGCAAAGGCAGGGCATTCGATTGGTCAAAAATTCATCTGAAGGGATTGGAGTTCCTGGACCCTA AAATGAGAGGGTATGTTTATGAACAACTGCATGAAAAATATGGTTATGTCTCATATACAACAAAACGCGA ACCTAATATTGAATTTTTCACCTTAAAAACTCCTGATGGATCTGAATTGGATTCAGTGCAAGTTACAGGT GAAGATGAAGAAAAAAAACCAATGAGGGAGCGCAAGTTTATTATTACCTGTATTGCGCGGGATCAAAATT TCATTAATTGGATAAAGGATTTAAACTATACGGCAAAAAATCTGGGTGCCACAGCCATCAGTTTCAACTA CAGAGGCGTGGATTACAGTCGCGGTCTTGTCTGGACAGAAAATAATCTTGTCGACGATATTCTGGCTCAG GTGCAAAGGCTAATTAGCCTTGGTGCCGACCCTAAGAACATCTGCCTTGATGGTATGTGTATAGGTGGGG CGGTAGCAACAATTGCCGCAGCAAAACTTCATGAGAAGGGCATGAAAGTCAAGTTGAATAATGAACGCTC TTTTACTTCTCTTTCTTCTCTAGTATTTGGTTTTATTGTACCTGAATTGCAAACAGCAAATTGGTGGAGC CCTTTGACTTATGGTCGCTTCCTACTGGCTGGTGTAGTTTATGCTTTACTCACGCCTTTAATTTGGCTGG CAGGCTGGCCAGTTGATGTGACCAAAGCCTGGAATAGAATACCTGCTCAGGATAAAATGTATTCTGTTGT GCGGGATAAAGACAATGGCTTGTACGATGGAGTAATTCACGATCACTTCTGTTCCATTGCGTCGTTGGTT GATTCTCAAATTAATTCTATTTTATACAAATTATCCACTGATCAGCTGCTTACTGAGGAAGAAAAACAAA TTTTGTGTGATGATCAGCTTTCTCACCATTTTAAACCAAGTCAAAGTGTTTTAAAAAATCCAAAATACAA AGGCCCGCATTTTATTTCCCGACAAGATTTGGTAGCTGAGCTTGGTCATCGAGAGGAATATACCAATCAT GATTATTTCCTTGACCGCTTGCGGGAAAAATTTCAATTGGATCGTACAATACGGCCAGTGGCTTTGGCTG AAGATGGGGAAAAGGATATAGATGGGATTCCACCGCAACTATCTAATCATAAAGAGCGTCCCTTAATTAT TGCCAGCAGTGGAGGAACAGGGCATATCTCTGCCACTCATGGCATCATTAATGATTTACAGAGTAAAACA GATAATGTTGTCATTACGCAGCATCATGCGGAGCTCTACAAAAACAAGCCCTTCTCAATTACATCTGTTC TGATTCGTATTGGTGTTTGGTTGACCTCCCTTCCTGTCCTGGAGGACATACTGAAAGGAGTTATGAGGTT TATCGGATATCCCGTTTTACCGAGCTCCTCCATCTTTTGGGATCAAATGTCTAAAATACAGCAAAGTGAA ACTAAAAAAGAAAATGGAATTGAAACAGGCAGAACCCGTCCTTATGTGGACATGTTGTTGGATATATACC CAGAGGGATATGAATACACAGCATTCAATAACGCGACTCACTTGACTTCCAGTATTGAAGACATTCAAAC GATGATAAGCTTCAAGGGGCATGTTGAAGAGGATAACAGGAATATAGTCTATCAAAATATATTACAACGC CTTATGCATGCGGCGAAACAGAGTACTCCTTACACAAGATTAATTTCCACACAGGCGCTTTCTTTGGGAG CTATTTGCGATGCCGTTAAATACTACAATACGGTATTTTTGCCTGTATACAATGCTGAAAGAGGAACCTC CTATCAGCCTATTACCATTGATCAGTATATGACCGATTTGCCTTCACTGGGTTGTATTCATTTTATGAAT AATTTGGAGGAGCTCACATCAGAGCAAAGGCAATTGATGGAGATACATGCAGTAAATATGAGTGAACCAT TTAAAGAGGCGCATTTTGGTAAAGAACAAGGCTTTAAAGCGGTTCATAACATTGACCCACGTAATAACCC AATGATTCGCAATGCCTTTAAAGATCTTTCATTGACAAAATACCTGGATAAGACACAGTCATTTGATTTG CACTTTAATGTTTATAAAAAGGAAAAACAAAATGCACTGCCAGTACTGAATGGTAAAGAAAAAATTACAA TCAAACCGCATGCTAAAATTGCTTCCATCATGATAGGCTCTCTGGCGGCAAATGCTTCAGCTGATTATGC GCAGTATTTATTGAATCAGGGGTATGATCATATTTTTCTTTTCGGCGGGCTTAATGATTCCATTGCCGCA CGCATCGATCAGATCATCAATTCTTACCCTGACTCCAGGCATGATGAGATACGTAAGAAAATTATTCTCC TGGGGAATCAATCTGATGTTGAAATGGCACCGATAATGACCAGAAGTAACTGTGTGGTTATCCGTGGGGG TGGTTTAAGTGTCATGGAGCAAATGGCTATGCCCATTATGGATGAGAAAATTGTATTACTACATCATGAA GATAATGAAGAGGGGCCTTTAACGTCTGGTCTCAGTTGGGAGGATGGGAATGCCGATAAATTAATCGAGT ATCTATCCGAAAAAGGGGCATATGCTAAAAAAACATCACCTGGCTTGTGTTCTGGCCATCTCAATGAGGC AGAAAAGGATTTTGAAAAGAAATATATTACCCAACTAAAATCGAAGGGAACCAAGGAAAAAGTAGATTTA ACCATTCCTCAGCAAAAGAAGCCTCCCCTGAAAAAAGAGTGGGGTAGAAAAACAGGTTATACTGAACTCG GGCACGTATTATCCCATCAACATAGGTTTTTTGAAACGATTCCTGAAGTAAGAGAGCCATTCTGTTCTAA GGAAGATTTACATCATCATGAGCTTTCCAGTCAAAGTTTGGTTAGTGTAACAGTTGGTTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |