| Effector Protein ID: 296105613 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_00152 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 126406..127266 [-] |
| Product | N-terminal acetyltransferase, GNAT family |
| Effector type | Protein |
| Descripton | VipF |
| T4CP requirement | T4CP Depedent |
| Target/Effection | VipF has been found to inhibit lysosomal protein trafficking in yeast (Shohdy, et al. 2005) |
| UniProt ID | D5T6C1 |
| KEGG ID | lpa:lpa_00152 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Acetyltransf_1 [PF00583], Evalue: 1.4e-23, Aligned region: 51..108 Acetyltransf_1 [PF00583], Evalue: 1.4e-23, Aligned region: 192..269 Acetyltransf_7 [PF13508], Evalue: 5.2e-17, Aligned region: 48..102 Acetyltransf_7 [PF13508], Evalue: 5.2e-17, Aligned region: 190..269 Acetyltransf_10 [PF13673], Evalue: 2.7e-15, Aligned region: 48..123 Acetyltransf_10 [PF13673], Evalue: 2.7e-15, Aligned region: 175..268 FR47 [PF08445], Evalue: 1.2e-09, Aligned region: 210..273 Acetyltransf_3 [PF13302], Evalue: 1.6e-09, Aligned region: 172..268 Acetyltransf_8 [PF13523], Evalue: 1.2e-08, Aligned region: 171..272 |
| Protein Sequence: 286 a.a. [Download] |
| >gi|296105613|ref|YP_003617313.1| N-terminal acetyltransferase, GNAT family [Legionella pneumophila 2300/99 Alcoy] MITQVNQLDELQLKDLKTLRAECKKNDGSIPNLYIHILKQHRSLPTSFLYYQNGALIGFLSVYFFYDDAV EVAVLVSPQYRRQGVAKQLIKEALPLIKSQNYFNLIFSCPSRLNDNWLTQKGFTYLHSEYFMERDDLNPI LDYIRPLSFRMATLEDIPILCGLDEVCFPDKNQDSVNRFQQILNEREYEIVIAMLNNHPIGKAHIRWQTK RATLSDIAILPKEQGKGFGSALIAHCINMILSEGKSRVDLDVETHNKKALNLYIQLGFHIQNACDYWSIN VNQLAK |
| - |
| Nucleotide Sequence: 861 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:c127266-126406 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGATTACTCAAGTTAACCAATTAGATGAACTTCAATTAAAAGACTTAAAAACATTAAGAGCAGAGTGTA AAAAAAACGATGGCAGCATCCCCAATCTATATATCCATATATTGAAACAACACCGCTCTCTTCCTACAAG CTTTCTTTATTATCAAAACGGGGCCTTGATTGGATTCTTGAGTGTTTATTTCTTTTATGATGATGCTGTT GAAGTCGCTGTTCTGGTTAGTCCCCAATATCGCAGACAAGGGGTTGCCAAACAATTAATAAAGGAAGCAT TACCCTTAATTAAGTCTCAAAACTACTTTAACTTGATTTTTTCATGCCCCTCACGCCTCAATGATAACTG GTTAACCCAAAAAGGATTTACCTACCTGCATAGCGAATATTTCATGGAACGTGATGATTTAAATCCTATA CTCGATTACATACGTCCATTGTCCTTTCGCATGGCGACTTTAGAGGATATTCCCATATTATGTGGCCTCG ATGAAGTATGTTTTCCTGATAAAAACCAAGACTCGGTTAACCGATTCCAACAAATTCTTAACGAAAGAGA ATATGAAATTGTAATAGCCATGCTCAATAATCATCCCATAGGAAAAGCCCATATTCGCTGGCAAACCAAA AGGGCTACCTTGTCTGATATTGCCATATTACCTAAAGAACAAGGAAAAGGATTTGGTTCTGCCTTGATTG CTCATTGCATCAATATGATTTTGAGCGAAGGCAAATCCCGGGTGGATCTTGACGTTGAAACCCATAATAA AAAAGCATTAAATCTGTATATTCAGCTTGGATTTCATATTCAAAATGCTTGTGATTACTGGTCAATTAAT GTGAATCAACTTGCAAAATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |