| Effector Protein ID: 289165017 |
 T4SS name [ID] | Dot/Icm [44] |
| Gene symbol | - |
| Locus tag | LLO_1682 |
| Strain | Legionella longbeachae NSW150 |
| Replicon | chromosome [GenBank: NC_013861] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1990167..1991777 [-] |
| Product | serine/threonine-protein kinase |
| Effector type | Protein |
| Descripton | LegK1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | The canonical serine/threonine kinase activity of LegK1 is essential for potent activation of the NF-kB pathway. LegK1 mimics host IKK and directly phosphorylates the Ser32 and Ser36 residues of the inhibitory IkBa protein, leading to IkBa ubiquitination/degradation and subsequent nuclear translocation of p65. (Ge and Shao, 2011) |
| UniProt ID | D3HT16 |
| KEGG ID | llo:LLO_1682 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pkinase [PF00069], Evalue: 8.2e-20, Aligned region: 84..372 Pkinase_Tyr [PF07714], Evalue: 6.4e-06, Aligned region: 84..363 |
| Protein Sequence: 536 a.a. [Download] |
| >gi|289165017|ref|YP_003455155.1| serine/threonine-protein kinase [Legionella longbeachae NSW150] MSIKINLDPTQIHGTNLGEAERNALQEFLKNKHLDNMWLKNQEYQYTTTQGIEYIFCFSKSLLRRKRSKL KEGERFEIFDLSNEPLGQGGYAVVYPILGTIKFEANYPILKTGKNRIVKIEKHHEYDRSHSVLQEYNNLV HVGHLGPKPPVFVHNNGKKSLLVMKLAKGIPLETILNPNKRKKYADFIPILTVEKRLEITFAILDAVKEQ VIDKNLIHRDLKPGNMIIDLSRSSSISIDMEGNTSINPPSKVTIIDYGNAIIGNRIERRRVGTAAYRPPE LYLSTPSYTQKSDAYAVGRILSYLWGDDYKNYYLDHKSPWIEIKKKTQNNNLFSDPQIALFKKDEDQIRE CLNGLLKEDITERWSVEKAKQSFLKVNLQKYQIKKIRHASKIELRHYEKSIEKQIQTIVTLISRLSKKGN ELIQRGFGQEGKKAEYLANKLKEYTEALAKNPDPTLFKLYRTKCLIKIDSSRKMLQKHRDSRWIVAEIIT AISLLGIGYLFALGINYKITGRLGLFSQTKSDQTVEKLRNSIYQLS |
| - |
| Nucleotide Sequence: 1611 bp [Download] |
| >gi|289163353|ref|NC_013861.1|:c1991777-1990167 Legionella longbeachae NSW150 chromosome, complete genome ATGTCGATAAAAATCAATCTTGATCCCACTCAAATACATGGAACGAATCTGGGTGAAGCTGAAAGGAATG CCCTCCAAGAGTTTCTAAAAAATAAACATCTGGATAATATGTGGCTTAAAAACCAAGAGTATCAATATAC TACAACTCAAGGTATTGAATATATTTTTTGTTTTAGTAAATCACTATTAAGAAGGAAACGAAGTAAGCTC AAGGAAGGAGAGCGGTTCGAGATATTTGATTTAAGCAATGAGCCTTTAGGTCAGGGTGGGTATGCTGTAG TTTATCCCATATTAGGAACAATAAAGTTTGAAGCCAATTATCCAATTTTAAAAACGGGTAAAAATCGAAT AGTCAAGATAGAAAAGCACCATGAGTATGATCGAAGTCATTCAGTGCTTCAAGAATATAATAATCTGGTC CATGTTGGACATTTAGGTCCTAAACCACCGGTGTTTGTTCATAATAACGGGAAAAAAAGTTTGCTAGTAA TGAAGCTGGCAAAAGGTATTCCTCTAGAAACAATACTTAATCCTAATAAACGAAAGAAGTATGCGGATTT TATCCCCATACTCACTGTAGAAAAACGTCTGGAAATTACTTTTGCGATTCTTGATGCAGTGAAAGAACAA GTAATTGATAAGAATTTGATTCATCGTGATTTAAAACCAGGTAATATGATAATTGATTTAAGTAGATCGT CTTCCATTTCTATTGATATGGAGGGAAATACAAGCATTAATCCCCCCTCTAAAGTAACGATTATTGATTA TGGAAATGCAATAATAGGCAACCGTATCGAAAGACGAAGAGTAGGTACCGCCGCTTATAGGCCTCCTGAG CTCTATTTGAGTACTCCAAGCTATACTCAAAAATCAGATGCTTACGCCGTAGGGCGAATTTTAAGCTATT TATGGGGTGATGATTATAAAAATTATTATTTAGATCACAAGTCTCCTTGGATTGAAATTAAAAAGAAAAC CCAAAATAATAATTTGTTTTCAGATCCGCAGATAGCTCTTTTCAAAAAAGATGAAGATCAAATAAGAGAA TGTCTCAATGGTCTTTTAAAAGAAGATATTACAGAGCGCTGGAGTGTGGAAAAAGCGAAACAGTCTTTCT TAAAAGTAAACCTCCAAAAATATCAAATAAAGAAAATTCGACACGCATCTAAAATTGAGCTTAGACATTA TGAAAAATCAATAGAAAAACAAATTCAAACAATTGTTACATTGATCTCGAGACTTTCTAAAAAAGGTAAC GAGTTAATCCAAAGAGGGTTTGGCCAAGAAGGTAAAAAAGCAGAATATTTAGCAAATAAATTGAAAGAAT ACACAGAAGCACTTGCTAAAAATCCGGATCCCACATTGTTTAAACTTTATCGAACAAAATGTTTAATAAA AATAGACTCATCTAGAAAAATGTTACAAAAACATCGTGATTCAAGATGGATAGTTGCTGAAATAATTACT GCAATTAGTTTGTTAGGAATCGGATATTTATTTGCATTAGGTATTAATTATAAAATCACCGGCAGATTAG GTTTATTTTCGCAAACTAAATCAGATCAAACAGTTGAAAAGCTCAGAAACTCTATTTATCAGCTTTCATA A |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |