| Effector Protein ID: 289163893 |
 T4SS name [ID] | Dot/Icm [44] |
| Gene symbol | - |
| Locus tag | LLO_0548 |
| Strain | Legionella longbeachae NSW150 |
| Replicon | chromosome [GenBank: NC_013861] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 619308..624842 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | SdhA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SdhA is critical for intracellular growth and functions to prevent host cell death. SdhA also functions to inhibit Legionella infection-induced type I interferon response. Besides, SdhA prevente bacterial DNA release and AIM2 inflammasome activation. |
| UniProt ID | D3HPR7 |
| KEGG ID | llo:LLO_0548 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1844 a.a. [Download] |
| >gi|289163893|ref|YP_003454031.1| hypothetical protein LLO_0548 [Legionella longbeachae NSW150] MIEEYIKLLESFKRNQISKLLERIDTKLFEILYSKHVSPRLIPFFPRYELCFMTDETKLEPGKLYVRENQ GKITYSVIAPNGETIEDAVLEEPASPSPFKYKLALMSDMVTPQKGFFYVRMLNEGFEYTVIDPNGKTVTG LIKKEELKVNPNSNLSFENLESLMPEIINLTAKKKHTHPFVLTALKPNILSAVARKGHIQWAPFTDYSLD PDNISQIKKLINALYHGRRTFIDLENADVRNKPYTDLKSLWNKTVDSAYEASYLLTHLDVDLTDMFSEEL AVILPLFSQIQGFTENHVEEQQAIVDALQPKPLAYNAGKVAGITVDQLRPLDGDVDYNFLTQFSAVLPSY IDKLTQHIQQFSSQIKESEPKLNKEKLDELQNAALHLLNDLESLKGGSVFVSLKFLNYIHIIRNIITLSM SSLEQIGELSDSSQDLVRDKLAYLKYSLIPTLFGLVDKIEDNAMLKPGTLSVPLMEKVKVLYEAILYLPK KAVDFKTKGAELLEIEDPRFIESRLEMSYKRIDKANKALYKIQKAREACSQFFEILNDPRYTNVRIYQFP PEVKKELIKNYKLISPYMSKLDIDFNTLIIEKLNAEKEDWNSYLKKPWRLLRGQYPADHIRFVLEKQKAV EDLIIKAENSQLFHINLNKDLIESVHKNTKLFLFPYSEKENVYSLDESGPLQIEKDIHKKFKLTKAEFQR VQNAYIRFAQIVKRQIAAQPELENNLALNKLESTLQNECQRLYNVFQPYLCAFTTYQYQDAAKSLEQHLS EFFTKKTNTDAPTTKLFLNLDKNIQEFFNQINYDWSNKSELQQAQSAYIRFSQLIKKQIDVKPELYGNSL LLTNLDEETKKQCQNFYQTFKPYFKFLVSSDLKDSAQNFEQYLVDLFANKPLDILDAPATSLFLKLDKEI LVFFEKSKEKKDKEFFTKWKDKSEFYYDFSKKSFLSEEESKNLQIKREQDAKLHFKKEESNKILQNPEQL SADQALDMWQWYRNKYNKFLVVRNAYAQFLELIRPQLSGKKLLLENLDPQVKEQCRNLYSIFQSYLLGAV PVENKEAALEFDKYIVDSLSNRKLSNKDKPSIHTFRDLDRHFQVFFSRTHRKWQTRAQTYYDLAQEKFIL ENEHNDLDPKANKRAHYVISHTNYSKAIHEFRSSLFEITKLFNKAMRAELRPQNAGVPFPEMENDNRRLA QSKQVCALKDIFNSMYHLEGIVLELEKLNNNSAKSLYVYYLLQAYGHVNEIIKLTQRLVADPHLGFIARE LQDKAQNLYATIQEQSDAYQVGPEQVRYGSPTVQYNALWYVLNAFYIGPKHIRALNNTNYLTTEELDDLH IRAKKATLFIENLIKSSDSYFKLFLQTPNMIYLYQELTQKLNEFTTTSHDAVLNNINQMQSAVFTPMLLE ADLWENRLGLEPGKLSEPLRQITNEFFKGLLHPFGLDSKTHLSLVCDQEPLSKRTVLTNNQIKSAKKYLK NIENEYKDIEDLYQCYLLYHDPESILPSEEETKRNKENLRIAYQKARPKIVKLIQDKKINIEPSNYPEDL ALDELCNSGLKTHLNPPTQVEALIKASHHYYLGLKATHEMRLATAEEKLTYLTDLVGVQEKENTTFVEQY TTESFDKHYTLYCNRHIGLQYTDKEYQAKLEKYLLNFRNEIIAESKTANDINLNIQKRLKEKISLFEKRH YAEYYHLDSVRVALAQFKNYFSYSTVQIQKNNSLFESETTLNQKSKCIKELEDIAETPHLEVKERLDLIK NKVKNPNFERIILNHRQTNTFSFNFLKICFLSLLEALHLYTPTRKKLLDGVNNAVHHPPEISELTKRFGL FVSAPTKDVTKKYEAPTLITAPTA |
| - |
| Nucleotide Sequence: 5535 bp [Download] |
| >gi|289163353|ref|NC_013861.1|:c624842-619308 Legionella longbeachae NSW150 chromosome, complete genome ATGATTGAAGAATATATAAAATTATTAGAGTCATTTAAACGAAACCAGATATCAAAATTATTAGAACGCA TTGATACAAAATTATTTGAAATCCTCTACAGCAAACACGTTAGCCCACGCTTAATTCCTTTTTTTCCACG TTATGAACTTTGTTTCATGACCGATGAAACAAAATTAGAACCCGGTAAACTCTATGTTAGGGAAAATCAA GGAAAAATTACCTATTCGGTCATAGCCCCCAATGGCGAAACAATCGAAGATGCGGTCTTGGAAGAACCTG CTTCCCCGTCCCCTTTTAAATATAAGCTGGCGTTAATGTCTGACATGGTGACGCCTCAAAAAGGTTTCTT TTATGTTCGTATGTTGAATGAGGGATTTGAATATACGGTGATTGATCCTAATGGAAAAACAGTTACCGGC CTCATAAAAAAAGAAGAACTTAAAGTGAACCCGAACTCTAATCTTTCTTTTGAAAATTTAGAGTCATTAA TGCCCGAAATTATCAATCTAACGGCAAAAAAGAAACATACCCACCCATTTGTATTAACCGCACTTAAACC AAATATACTTTCAGCTGTTGCAAGAAAAGGCCATATTCAATGGGCCCCCTTTACTGATTACTCCCTCGAT CCTGATAATATTTCTCAGATTAAGAAACTAATTAATGCGCTTTACCATGGGCGACGCACCTTTATAGATT TAGAAAATGCTGATGTTAGAAATAAACCTTATACTGATTTGAAATCACTTTGGAATAAGACTGTTGATTC AGCTTACGAAGCAAGCTATTTGCTGACTCATTTAGATGTCGATTTAACAGACATGTTTAGTGAAGAATTA GCCGTTATATTGCCACTATTCAGTCAAATCCAGGGTTTTACAGAAAATCATGTAGAGGAACAACAGGCTA TAGTAGACGCATTACAACCTAAGCCATTAGCTTACAATGCAGGAAAAGTGGCTGGGATTACGGTTGATCA ATTGCGCCCTCTTGATGGGGATGTGGACTATAATTTTCTAACCCAATTCAGTGCGGTCTTACCTAGTTAT ATTGATAAGCTAACCCAGCATATTCAACAATTTTCATCTCAAATTAAAGAATCGGAACCTAAACTTAATA AAGAAAAGCTAGACGAGTTACAAAATGCCGCACTTCACTTATTAAATGATTTAGAGAGTTTAAAGGGTGG CAGCGTTTTTGTTTCACTTAAGTTCTTAAACTACATCCATATCATACGCAATATTATTACCTTATCCATG AGCTCACTGGAACAAATAGGAGAGCTAAGTGATTCATCCCAGGATTTAGTCCGTGATAAATTAGCCTATT TAAAATATAGTTTAATACCCACTTTATTTGGTTTAGTCGACAAAATTGAAGATAATGCCATGTTAAAACC GGGAACATTGTCAGTTCCCCTGATGGAAAAAGTGAAAGTACTCTATGAGGCAATTCTTTATCTGCCTAAA AAAGCAGTCGACTTTAAAACTAAGGGAGCAGAACTACTTGAGATTGAGGATCCACGCTTTATCGAATCAA GATTGGAAATGTCCTACAAGCGAATTGATAAGGCAAATAAGGCATTGTACAAAATCCAGAAAGCACGGGA AGCCTGTTCCCAATTTTTCGAAATATTAAATGATCCTCGTTATACAAACGTTCGGATATATCAGTTTCCC CCAGAGGTTAAAAAAGAGCTGATAAAAAATTATAAATTGATTAGTCCTTACATGTCTAAGCTGGACATTG ATTTCAATACATTAATTATTGAAAAACTCAACGCAGAAAAAGAAGATTGGAACTCTTATCTAAAGAAACC ATGGCGTTTGCTCAGGGGACAATATCCCGCAGATCATATACGCTTTGTTTTAGAAAAACAAAAGGCTGTG GAAGATTTAATTATAAAAGCGGAAAACAGCCAACTCTTTCATATTAATTTAAATAAAGATCTCATCGAAT CAGTCCACAAAAACACCAAATTATTTTTATTTCCTTATAGTGAAAAAGAAAATGTCTATTCTCTTGATGA GTCCGGACCATTACAAATTGAAAAAGACATCCATAAAAAATTCAAGCTTACGAAAGCCGAATTTCAACGT GTACAAAATGCCTATATTCGTTTTGCCCAAATAGTAAAAAGACAAATAGCAGCCCAGCCTGAACTAGAAA ACAATTTAGCGTTGAATAAGCTTGAAAGCACATTACAAAATGAATGTCAGCGCTTATACAACGTCTTTCA GCCTTATCTGTGCGCGTTTACCACATATCAATATCAAGATGCAGCCAAAAGCCTAGAGCAACACTTGAGC GAATTTTTTACAAAAAAAACAAATACAGATGCCCCAACTACAAAACTTTTTCTTAATCTTGATAAAAATA TCCAGGAGTTTTTTAATCAAATAAATTATGACTGGTCTAACAAAAGTGAACTTCAACAAGCTCAATCTGC TTATATTCGCTTTTCACAACTTATAAAAAAACAAATAGATGTTAAACCAGAACTTTATGGCAACAGTCTG CTTCTCACTAATCTTGATGAAGAGACCAAAAAGCAATGTCAAAATTTTTATCAAACTTTTAAACCCTATT TCAAGTTTTTGGTATCATCTGATCTTAAAGATTCCGCGCAAAACTTTGAACAATATTTAGTTGATTTATT CGCTAATAAACCCTTGGATATTTTAGACGCCCCAGCTACTTCTTTATTTTTAAAACTGGATAAAGAGATT CTGGTGTTTTTTGAAAAATCGAAAGAGAAAAAGGATAAAGAGTTCTTTACCAAATGGAAAGATAAAAGTG AATTTTATTACGACTTTTCGAAAAAGAGTTTTCTTTCTGAAGAGGAATCAAAAAACTTACAAATTAAACG CGAACAAGATGCAAAGCTTCATTTTAAAAAAGAAGAAAGTAATAAAATACTTCAAAATCCTGAGCAATTG AGTGCTGATCAGGCTCTTGATATGTGGCAGTGGTATCGAAATAAATATAATAAATTTTTAGTTGTTCGAA ATGCATATGCCCAATTTCTAGAACTTATAAGACCTCAACTTAGCGGAAAAAAACTACTCCTTGAGAATCT TGATCCTCAAGTAAAGGAGCAGTGCCGTAATTTGTATAGTATTTTCCAATCCTATCTTCTTGGTGCTGTC CCTGTAGAAAATAAAGAAGCTGCGCTGGAATTTGATAAATATATCGTTGATTCATTATCAAATAGAAAGT TAAGCAACAAAGATAAGCCCTCGATACATACATTCAGGGACTTAGACCGCCATTTTCAAGTTTTTTTTAG CAGAACTCATAGAAAATGGCAAACAAGGGCTCAAACCTATTATGATTTGGCCCAAGAAAAATTTATTCTT GAAAATGAGCACAATGATCTAGATCCCAAAGCAAATAAAAGAGCTCATTATGTCATTTCACATACTAATT ACTCAAAAGCCATCCATGAGTTTAGATCATCCTTATTTGAAATTACAAAACTATTTAATAAAGCAATGAG GGCCGAATTAAGACCTCAAAACGCAGGGGTTCCTTTCCCCGAAATGGAGAATGACAACCGAAGATTAGCG CAAAGCAAACAGGTATGTGCTTTAAAAGATATATTTAACAGTATGTACCATCTGGAAGGCATTGTTCTTG AATTAGAGAAATTAAATAATAACAGTGCTAAAAGTCTTTATGTATATTATTTATTACAAGCGTATGGGCA CGTTAACGAAATCATTAAACTAACCCAGCGCTTAGTTGCTGATCCTCACCTGGGATTCATTGCTCGCGAA TTGCAGGATAAAGCCCAAAATCTATATGCAACTATCCAGGAGCAATCCGATGCATACCAAGTTGGTCCAG AGCAGGTTCGTTATGGCTCACCTACGGTACAATATAATGCACTTTGGTATGTCCTTAATGCCTTTTATAT AGGACCTAAACACATAAGGGCCTTAAACAATACGAATTATCTAACTACAGAAGAACTCGACGACTTACAT ATTCGCGCTAAAAAAGCGACTTTATTCATTGAAAACTTGATAAAAAGCTCTGACTCTTATTTCAAATTGT TCTTGCAAACACCAAACATGATTTATCTGTACCAAGAGCTAACTCAAAAACTCAATGAATTCACAACGAC ATCTCACGACGCGGTTCTTAACAACATAAACCAAATGCAATCTGCGGTATTTACTCCTATGCTTCTTGAA GCGGATCTTTGGGAAAATAGATTGGGATTAGAACCGGGGAAACTATCAGAACCTTTAAGACAAATAACCA ATGAATTTTTTAAGGGATTACTACACCCGTTTGGCTTAGACTCCAAAACCCATCTATCCTTAGTTTGTGA TCAAGAACCCTTGAGTAAAAGAACGGTATTGACGAACAATCAAATTAAAAGTGCGAAAAAGTATCTTAAA AATATAGAAAATGAATATAAAGATATTGAAGATTTATACCAATGTTATCTTTTATATCATGATCCTGAAA GTATTTTGCCATCAGAAGAAGAAACAAAGAGAAATAAAGAGAATTTACGGATAGCCTACCAAAAAGCACG CCCTAAAATTGTAAAACTAATACAAGATAAAAAAATTAATATTGAACCTAGCAATTATCCTGAAGATCTT GCACTTGATGAACTCTGTAATTCCGGATTAAAAACTCATCTTAATCCTCCCACTCAAGTCGAAGCATTAA TCAAAGCAAGCCATCATTACTATTTAGGTTTAAAAGCAACCCATGAAATGAGACTTGCTACTGCGGAAGA AAAATTAACCTATCTTACTGATTTAGTTGGAGTTCAGGAAAAAGAAAATACTACGTTTGTTGAACAATAT ACTACAGAATCCTTTGATAAGCATTATACACTTTATTGCAATCGACACATTGGACTGCAGTACACAGACA AAGAGTATCAAGCTAAGTTAGAAAAATACTTGCTTAATTTCAGAAATGAAATCATCGCTGAATCAAAAAC AGCAAATGATATTAATTTAAACATACAAAAACGGTTAAAAGAAAAAATTAGTCTTTTTGAAAAAAGACAT TACGCCGAATACTATCATCTTGATTCAGTCCGAGTCGCTTTAGCCCAATTCAAAAATTACTTTAGTTATT CTACGGTACAGATACAAAAAAATAATTCATTATTTGAAAGTGAAACAACTTTAAACCAGAAAAGCAAATG CATCAAGGAGCTTGAAGATATTGCAGAAACCCCCCATTTAGAGGTAAAGGAACGTTTGGATCTGATTAAA AATAAAGTTAAAAACCCTAATTTTGAACGTATTATCCTTAATCACAGACAAACCAATACTTTTAGTTTTA ATTTCTTAAAAATATGTTTCCTATCTTTGTTAGAGGCATTGCATTTATATACTCCAACTCGCAAAAAACT TTTGGATGGTGTCAATAATGCAGTGCATCACCCTCCCGAAATAAGTGAATTGACAAAGCGCTTTGGTTTG TTTGTTTCTGCACCTACGAAGGACGTCACAAAAAAATATGAAGCACCAACCCTCATTACAGCTCCTACAG CTTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |