SecReT4
Effector Protein ID: 23501622
T4SS name [ID]VirB [378]
Gene symbol-
Locus tagBR0735
StrainBrucella suis 1330
Repliconchromosome II [GenBank: NC_004310] [Browse all T4SS(s) in this replicon]
Location [Strand]721187..722020 [+]
Producthypothetical protein
Effector typeProtein
DescriptonBtpB
T4CP requirementT4CP Indepedent
Target/EffectionBtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells.BtpB plays a major role in the modulation of host innate immune response during infection.
UniProt IDNA
KEGG IDNA
PDB IDNA
Domain hit(s) vs Pfam TIR_2 [PF13676], Evalue: 7.5e-08, Aligned region: 144-270
Protein Sequence: 277 a.a.     [Download]
>gi|23501622|ref|NP_697749.1| hypothetical protein BR0735 [Brucella suis 1330]
MPCTFDLSRCVNQHEYTDQKIAEKFGKLDGAELAELTRLPTIFAYEAACKLDPKFGLIRDVTVRRGQVRI
EYEFIPVQPFLTVADFDTLAFELDIGNWEMNRTHWAVKDVNLPKELHTAKGITLPSWTRQASRAVDITQH
DFDVGLSFPGEARGLVEQVARELEARVGPNAYFYDNNYVSQLARPSLDTLLQDIYRNRCKLIVVFVGDDY
QRKDWCGVEFRAIREIIMARAEQRIMFVRVDDGAVDGVFRTDGYVDARRFNPSEIAQFIAERVALIT
-
Nucleotide Sequence: 834 bp     [Download]
>gi|56968325|ref|NC_004310.3|:721187-722020 Brucella suis 1330 chromosome I, complete sequence
GTGCCATGTACATTCGACCTGTCGCGTTGCGTTAACCAGCACGAATACACGGATCAGAAGATTGCCGAGA
AGTTCGGAAAGCTAGACGGGGCCGAACTGGCGGAATTGACGCGCCTTCCCACGATTTTCGCCTATGAGGC
TGCCTGCAAGCTTGATCCCAAGTTCGGGCTCATCCGCGATGTTACGGTAAGGCGCGGGCAAGTGCGAATC
GAGTACGAGTTCATCCCGGTCCAGCCCTTCCTGACGGTAGCAGACTTCGACACCCTCGCATTCGAGCTTG
ATATTGGCAATTGGGAGATGAATCGTACGCACTGGGCGGTCAAAGACGTAAACCTGCCCAAGGAGCTGCA
CACGGCCAAAGGAATAACTCTGCCGTCGTGGACGCGACAGGCGAGCCGTGCCGTCGATATCACTCAGCAC
GATTTTGACGTCGGTCTCTCTTTTCCCGGTGAGGCACGCGGGCTGGTCGAGCAAGTGGCCCGCGAACTCG
AGGCACGCGTCGGTCCAAACGCCTATTTTTACGACAACAATTATGTTTCCCAGCTTGCCCGACCGTCGCT
CGACACCCTACTTCAGGACATCTACCGCAACCGCTGCAAACTGATCGTAGTCTTCGTCGGCGACGACTAT
CAGCGAAAAGACTGGTGCGGCGTCGAGTTCCGCGCGATTCGCGAAATCATCATGGCACGGGCCGAACAAC
GGATCATGTTCGTGCGTGTGGACGATGGCGCTGTCGATGGCGTGTTTCGCACGGACGGCTACGTGGATGC
GAGACGGTTCAATCCTTCTGAGATCGCCCAGTTCATCGCCGAGCGCGTCGCCCTCATCACCTAG

Reference
(1) Salcedo SP et al. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. . Front. Cell. Infect. Microbiol. . 2013.00028 . [PudMed:23847770] experimental
 
experimental experimental literature