| Effector Protein ID: 23501622 |
 T4SS name [ID] | VirB [378] |
| Gene symbol | - |
| Locus tag | BR0735 |
| Strain | Brucella suis 1330 |
| Replicon | chromosome II [GenBank: NC_004310] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 721187..722020 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | BtpB |
| T4CP requirement | T4CP Indepedent |
| Target/Effection | BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells.BtpB plays a major role in the modulation of host innate immune response during infection. |
| UniProt ID | NA |
| KEGG ID | NA |
| PDB ID | NA |
| Domain hit(s) vs Pfam | TIR_2 [PF13676], Evalue: 7.5e-08, Aligned region: 144-270 |
| Protein Sequence: 277 a.a. [Download] |
| >gi|23501622|ref|NP_697749.1| hypothetical protein BR0735 [Brucella suis 1330] MPCTFDLSRCVNQHEYTDQKIAEKFGKLDGAELAELTRLPTIFAYEAACKLDPKFGLIRDVTVRRGQVRI EYEFIPVQPFLTVADFDTLAFELDIGNWEMNRTHWAVKDVNLPKELHTAKGITLPSWTRQASRAVDITQH DFDVGLSFPGEARGLVEQVARELEARVGPNAYFYDNNYVSQLARPSLDTLLQDIYRNRCKLIVVFVGDDY QRKDWCGVEFRAIREIIMARAEQRIMFVRVDDGAVDGVFRTDGYVDARRFNPSEIAQFIAERVALIT |
| - |
| Nucleotide Sequence: 834 bp [Download] |
| >gi|56968325|ref|NC_004310.3|:721187-722020 Brucella suis 1330 chromosome I, complete sequence GTGCCATGTACATTCGACCTGTCGCGTTGCGTTAACCAGCACGAATACACGGATCAGAAGATTGCCGAGA AGTTCGGAAAGCTAGACGGGGCCGAACTGGCGGAATTGACGCGCCTTCCCACGATTTTCGCCTATGAGGC TGCCTGCAAGCTTGATCCCAAGTTCGGGCTCATCCGCGATGTTACGGTAAGGCGCGGGCAAGTGCGAATC GAGTACGAGTTCATCCCGGTCCAGCCCTTCCTGACGGTAGCAGACTTCGACACCCTCGCATTCGAGCTTG ATATTGGCAATTGGGAGATGAATCGTACGCACTGGGCGGTCAAAGACGTAAACCTGCCCAAGGAGCTGCA CACGGCCAAAGGAATAACTCTGCCGTCGTGGACGCGACAGGCGAGCCGTGCCGTCGATATCACTCAGCAC GATTTTGACGTCGGTCTCTCTTTTCCCGGTGAGGCACGCGGGCTGGTCGAGCAAGTGGCCCGCGAACTCG AGGCACGCGTCGGTCCAAACGCCTATTTTTACGACAACAATTATGTTTCCCAGCTTGCCCGACCGTCGCT CGACACCCTACTTCAGGACATCTACCGCAACCGCTGCAAACTGATCGTAGTCTTCGTCGGCGACGACTAT CAGCGAAAAGACTGGTGCGGCGTCGAGTTCCGCGCGATTCGCGAAATCATCATGGCACGGGCCGAACAAC GGATCATGTTCGTGCGTGTGGACGATGGCGCTGTCGATGGCGTGTTTCGCACGGACGGCTACGTGGATGC GAGACGGTTCAATCCTTCTGAGATCGCCCAGTTCATCGCCGAGCGCGTCGCCCTCATCACCTAG |
| Reference |
(1) Salcedo SP et al. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
. Front. Cell. Infect. Microbiol.
. 2013.00028
. [PudMed:23847770] 
|
| experimental literature |