| Effector Protein ID: 212219375 |
 T4SS name [ID] | Dot/Icm [158] |
| Gene symbol | - |
| Locus tag | CbuK_1907 |
| Strain | Coxiella burnetii CbuK_Q154 |
| Replicon | chromosome [GenBank: NC_011528] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1842210..1843289 [-] |
| Product | ankyrin repeat protein |
| Effector type | Protein |
| Descripton | AnkB |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Inhibits apoptosis |
| UniProt ID | B6J5J1 |
| KEGG ID | cbc:CbuK_1907 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 3.7e-60, Aligned region: 37..129 Ank_2 [PF12796], Evalue: 3.7e-60, Aligned region: 145..270 Ank_2 [PF12796], Evalue: 3.7e-60, Aligned region: 223..303 Ank_2 [PF12796], Evalue: 3.7e-60, Aligned region: 246..335 Ank [PF00023], Evalue: 1.1e-50, Aligned region: 72..100 Ank [PF00023], Evalue: 1.1e-50, Aligned region: 105..127 Ank [PF00023], Evalue: 1.1e-50, Aligned region: 143..168 Ank [PF00023], Evalue: 1.1e-50, Aligned region: 274..305 Ank [PF00023], Evalue: 1.1e-50, Aligned region: 308..338 Ank_3 [PF13606], Evalue: 4.1e-40, Aligned region: 72..99 Ank_3 [PF13606], Evalue: 4.1e-40, Aligned region: 105..128 Ank_3 [PF13606], Evalue: 4.1e-40, Aligned region: 274..302 Ank_4 [PF13637], Evalue: 2.6e-37, Aligned region: 71..125 Ank_4 [PF13637], Evalue: 2.6e-37, Aligned region: 228..262 Ank_4 [PF13637], Evalue: 2.6e-37, Aligned region: 243..295 Ank_4 [PF13637], Evalue: 2.6e-37, Aligned region: 288..325 Ank_5 [PF13857], Evalue: 6.5e-30, Aligned region: 72..110 Ank_5 [PF13857], Evalue: 6.5e-30, Aligned region: 94..130 Ank_5 [PF13857], Evalue: 6.5e-30, Aligned region: 228..282 Ank_5 [PF13857], Evalue: 6.5e-30, Aligned region: 266..315 |
| Protein Sequence: 359 a.a. [Download] |
| >gi|212219375|ref|YP_002306162.1| ankyrin repeat protein [Coxiella burnetii CbuK_Q154] MRHPIIHKFISKLLNSPNSKGDYNYYFAIIKSKFIERACKRGNLELLKYFIIAKEYHVYQPLFFTDGRPP NRTALHIAAMFNQLEIVKYLIEEKGCDPNQLLPGGLTPLQEAASAGQLDVVKYLISRPGIRLDEAGEQDR CGTALYYAAFFGWRDIVAALIKAGANVNKGVQRAATGITQAPIETATRRLGAAQELTPLMGAVNRLFSLR GVENKKDALVQREIVIMLLAAGADPNRTKPAATTLLQRAVQYGDREIIRQLICRGVDVNPRGRNGATALM IACRMRLEEIVDQLIQARADVNLSTTTGRTPLYFACMWESVRMVRSLVKAGANPLASTVNYGPNRFFGGN RGWDGVLIF |
| - |
| Nucleotide Sequence: 1080 bp [Download] |
| >gi|212217688|ref|NC_011528.1|:c1843289-1842210 Coxiella burnetii CbuK_Q154 chromosome, complete genome ATGAGACATCCCATAATTCACAAGTTTATTTCAAAATTATTAAATTCGCCCAATTCTAAAGGAGATTATA ATTATTATTTTGCCATCATTAAATCGAAGTTTATAGAGCGAGCTTGTAAAAGGGGTAATCTTGAACTGTT GAAATATTTCATCATTGCCAAAGAATATCATGTCTATCAGCCTCTTTTTTTTACGGATGGTCGCCCCCCT AATAGAACAGCGCTTCACATTGCAGCTATGTTTAACCAATTGGAAATAGTGAAATATTTAATTGAAGAAA AAGGCTGTGACCCAAACCAGTTGTTGCCTGGTGGACTCACGCCGCTTCAAGAGGCAGCTTCTGCGGGTCA GCTGGATGTTGTTAAGTATTTAATTTCTCGCCCAGGGATTAGGCTGGATGAGGCGGGGGAACAAGATCGT TGTGGCACAGCATTGTATTATGCTGCATTCTTCGGCTGGAGGGACATAGTAGCGGCTTTAATCAAAGCTG GCGCGAATGTTAATAAGGGCGTCCAGCGAGCTGCTACTGGAATAACTCAAGCTCCGATAGAGACAGCCAC AAGGAGATTGGGGGCGGCACAAGAGCTGACGCCATTGATGGGAGCGGTTAACCGATTATTTTCTCTCAGG GGGGTGGAAAATAAGAAGGATGCGCTAGTTCAACGGGAGATTGTGATCATGCTGTTGGCCGCCGGTGCGG ATCCGAATCGGACTAAACCCGCTGCTACAACATTGCTGCAACGTGCTGTTCAATATGGCGATCGCGAGAT CATAAGGCAATTGATTTGTCGCGGAGTGGATGTGAATCCAAGAGGACGTAACGGAGCTACTGCCTTGATG ATAGCGTGTCGAATGAGACTTGAGGAGATTGTTGATCAACTCATTCAAGCACGTGCCGATGTTAATCTAA GTACTACAACAGGTAGGACTCCTTTGTACTTTGCATGTATGTGGGAGTCCGTGCGCATGGTGAGAAGTCT CGTGAAGGCGGGAGCGAATCCTCTTGCGTCCACAGTGAATTATGGACCCAATAGGTTTTTTGGGGGTAAT CGGGGATGGGATGGCGTCCTAATTTTTTGA |
| Reference |
| (1) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632] |
(2) Voth DE; Howe D; Beare PA; Vogel JP; Unsworth N; Samuel JE; Heinzen RA (2009). The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion. J Bacteriol. 191(13):4232-42. [PudMed:19411324] 
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(3) Pan X; Luhrmann A; Satoh A; Laskowski-Arce MA; Roy CR (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 320(5883):1651-4. [PudMed:18566289] 
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| experimental literature |
| in silico analysis literature |