| Effector Protein ID: 210134750 |
 T4SS name [ID] | Cag [35] |
| Gene symbol | cagA |
| Locus tag | HPP12_0555 |
| Strain | Helicobacter pylori P12 |
| Replicon | chromosome [GenBank: NC_011498] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 585581..589225 [+] |
| Product | cytotoxin-associated protein A |
| Effector type | Protein |
| Descripton | CagA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | CagA can cause gastritis and peptic ulcer, Injected CagA can act as a ‘master key’ that evolved the ability to highjack multiple host cell signalling cascades, which include the induction of membrane dynamics, actin-cytoskeletal rearrangements and the disruption of cell-to-cell junctions as well as proliferative, pro-inflammatory and anti-apoptotic nuclear responses (Backert et al, 2010). |
| UniProt ID | B6JLD1 |
| KEGG ID | hpp:HPP12_0555 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | CagA [PF03507], Evalue: 3.5e-130, Aligned region: 864..993 CagA [PF03507], Evalue: 3.5e-130, Aligned region: 979..1086 |
| Protein Sequence: 1214 a.a. [Download] |
| >gi|210134750|ref|YP_002301189.1| cytotoxin-associated protein A [Helicobacter pylori P12] MTNETINQQPQTEAAFNPQQFINNLQVAFLKVNNAVASYDPDQKPIVDKNDRDNRQAFDGISQLKEEYSN KAIKNPTKKNQYFSDFINKSNDLINKDNLIDVESSTKSFQKFGDQRYQIFTSWVSHQNDPSKINTRSIRN FMENIIQPPIPDDKEKAEFLKSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGEPTGGDWLDI FLSFIFDKKQSSDVKEAINQEPVPHVQPDIATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGV ADIDPNYKFNQLLIHNNTLSSVLMGSHDGIEPEKVSLLYAGNGGFGAKHDWNATVGYKDQQGNNVATIIN VHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIRNKIDFMELLAQNNAKLDNLSEKEKEK FQNEIKDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFGNGDLSYTLKDYGKKADKALDREKNVTLQ GSLKHDGVMFVDYSNFKYTNASKNPNKGVGVTNGVSHLEAGFDKVAVFNLPDLNNLAITSFVRRNLEDKL VTKGLSIQEANKLIKDFLNSNKELVGKALNFNKAVADAKNTGNYDEVKKAQKDLEKSLKKREHLEKEVAK NLESKSGNKNKMEAKSQANSQKDEIFALINKEANRDARAIAYAQNLKGIKMELSDKLENVNKNLKDFSKS FDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVAQAKSDLENS VKDVIINQKITDKVDNLNQAVSVAKATGDFSRVEQALADLKNFSKEQLAQQAQKNEDFNTGKNSALYQSV KNGVNGTLVGNGLSKAEATTLSKNFSDIKKELNAKLGNFNNNNNNGLKNEPIYAKVNKKKTGQAASHEEP IYAQVAKKVNAKIDRLNQIASGLGGVGQAAGFPLKKHDKVEDLSKVGLSASPEPIYATIDDLGGPFPLKK HDKVEDLSKVGLSASPEPIYATIDDLGGPFPLKKHDKVEDLSKVGLSRNQKLAQKIDNLNQAVSEAKAGF FGNLEQTIDKLKDSTKYNPVNLWVESAKKVPASLSAKLDNYATNSHTRINSNIKNGAINEKATGMLAQKN PEWLKLVNDKIVAHNVGSVPLLEYDKIGFNQKNMKDYSDSFKFSTNLNNAVKDIKSGFTQFLANAFSTGY YCLARENAEHGIKNVNTKGGFQKS |
| - |
| Nucleotide Sequence: 3645 bp [Download] |
| >gi|210134201|ref|NC_011498.1|:585581-589225 Helicobacter pylori P12 chromosome, complete genome ATGACTAACGAAACCATTAACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAATA ATCTTCAAGTGGCTTTTCTTAAAGTTAATAACGCTGTCGCTTCATACGATCCTGATCAAAAACCAATCGT TGATAAGAACGATAGGGATAACAGGCAAGCTTTTGATGGAATCTCGCAATTAAAGGAAGAATACTCCAAT AAAGCGATCAAAAATCCTACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAACGATTTAA TCAACAAAGACAATCTCATTGATGTAGAATCTTCCACAAAGAGCTTTCAGAAATTTGGGGATCAGCGTTA CCAAATTTTCACAAGTTGGGTGTCCCATCAAAACGATCCGTCTAAAATCAACACCCGATCGATCCGAAAT TTTATGGAAAATATCATACAACCCCCTATCCCTGATGATAAAGAAAAAGCAGAGTTTTTGAAATCTGCCA AACAATCTTTTGCAGGAATTATCATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGGCGTGTTTGA TGAATCCTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGAGCCTACTGGTGGGGATTGGTTGGATATT TTTTTATCATTTATATTTGACAAAAAACAGTCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTC CTCATGTCCAACCAGATATAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTT ACTTGATGAAAGGGGTAATTTTTCTAAATTCACTCTTGGCGATATGGAAATGTTAGATGTTGAGGGCGTC GCCGACATTGATCCTAATTACAAGTTCAACCAATTATTGATTCACAATAACACTCTGTCTTCTGTGTTAA TGGGGAGTCATGATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGCGGGCAATGGTGGTTTTGGAGC CAAGCACGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTGGCTACAATAATTAAT GTGCATATGAAAAACGGCAGTGGCTTAGTCATAGCAGGTGGTGAGAAAGGGATTAATAACCCTAGTTTTT ATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGTCAAGAAGAGATCCGAAACAAAAT AGATTTCATGGAACTTCTTGCACAAAACAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAA TTCCAAAATGAGATTAAGGATTTCCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTA TTGCTTTTGTTTCTAAAAAAGACACAAAACATTCAGCTTTAATTACTGAGTTTGGTAATGGGGATTTGAG CTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCTTTAGATAGGGAGAAAAATGTTACTCTTCAA GGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAAATACACCAACGCCTCCAAGA ATCCCAATAAGGGTGTAGGCGTTACGAATGGCGTTTCCCATTTAGAAGCAGGCTTTGACAAGGTAGCTGT CTTTAATTTGCCTGATTTAAATAATCTCGCTATCACTAGTTTCGTAAGGCGGAATTTAGAGGATAAACTA GTCACTAAAGGATTGTCCATACAAGAAGCTAATAAGCTTATCAAAGACTTTTTGAATAGCAACAAAGAAT TGGTTGGAAAAGCTTTAAACTTCAATAAAGCTGTAGCTGACGCTAAAAACACAGGCAACTATGATGAAGT GAAAAAAGCTCAGAAAGATCTTGAAAAATCTCTAAAGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAA AATTTGGAGAGCAAAAGTGGCAACAAAAACAAAATGGAAGCGAAATCTCAAGCTAACAGCCAAAAAGATG AGATTTTTGCGTTGATCAATAAAGAGGCTAATAGGGACGCAAGAGCAATCGCTTACGCTCAGAATCTTAA AGGCATCAAAATGGAATTGTCTGATAAACTTGAAAATGTCAACAAGAATTTGAAAGACTTTAGTAAATCT TTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACACTAAAAGCCCTTAAAG GTTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAA TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAGCGCAAGCAAAAAGCGACCTTGAAAATTCC GTTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGATAATCTCAATCAAGCGGTATCAGTGG CTAAAGCAACGGGTGATTTCAGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAACTTCTCAAAGGAGCA ATTGGCTCAACAAGCTCAAAAAAATGAAGATTTCAATACTGGAAAAAATTCTGCACTATACCAATCCGTT AAGAATGGTGTGAATGGAACCCTAGTCGGTAATGGGTTATCTAAAGCAGAAGCCACAACTCTTTCTAAAA ACTTTTCGGACATCAAGAAAGAGTTGAATGCAAAACTTGGAAATTTCAATAACAATAACAATAATGGACT CAAAAACGAACCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGGCAAGCAGCTAGCCATGAAGAACCC ATTTACGCTCAAGTTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTGGTTTGG GTGGTGTAGGGCAAGCAGCGGGCTTCCCTTTGAAAAAGCATGATAAAGTTGAAGATCTCAGTAAGGTAGG GCTTTCAGCTAGCCCTGAACCCATTTATGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAAG CATGATAAAGTTGAAGATCTCAGTAAGGTAGGGCTTTCAGCTAGCCCTGAACCCATTTATGCTACGATTG ATGATCTCGGCGGACCTTTCCCTTTGAAAAAGCATGATAAAGTTGAAGATCTCAGTAAGGTAGGGCTTTC AAGGAATCAAAAATTGGCTCAGAAAATTGACAATCTCAATCAAGCGGTATCAGAAGCTAAAGCAGGTTTT TTTGGCAATCTAGAGCAAACGATAGACAAGCTCAAAGATTCTACAAAATACAATCCTGTGAATCTATGGG TTGAAAGTGCAAAAAAAGTACCTGCTAGTTTGTCAGCGAAACTAGATAATTATGCTACTAACAGCCACAC ACGCATTAATAGCAATATCAAAAATGGAGCAATCAATGAAAAAGCGACCGGCATGCTAGCGCAAAAAAAC CCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGCGTTCCTTTGTTAGAGT ATGATAAAATTGGCTTCAACCAGAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAACTT GAACAATGCTGTAAAAGACATTAAGTCTGGCTTTACGCAATTTTTAGCCAATGCATTTTCTACAGGATAT TACTGCTTGGCGAGGGAAAATGCAGAGCATGGAATCAAGAATGTTAATACAAAAGGTGGTTTCCAAAAAT CTTAA |
| Reference |
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(6) Pattis I; Weiss E; Laugks R; Haas R; Fischer W (2007). The Helicobacter pylori CagF protein is a type IV secretion chaperone-like molecule that binds close to the C-terminal secretion signal of the CagA effector protein. Microbiology. 153(Pt 9):2896-909. [PudMed:17768234]
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| experimental literature |