| Effector Protein ID: 188527607 |
 T4SS name [ID] | Cag [36] |
| Gene symbol | - |
| Locus tag | HPSH_04145 |
| Strain | Helicobacter pylori Shi470 |
| Replicon | chromosome [GenBank: NC_010698] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 804109..807594 [-] |
| Product | cag pathogenicity island protein CagA |
| Effector type | Protein |
| Descripton | CagA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | CagA can cause gastritis and peptic ulcer, Injected CagA can act as a ‘master key’ that evolved the ability to highjack multiple host cell signalling cascades, which include the induction of membrane dynamics, actin-cytoskeletal rearrangements and the disruption of cell-to-cell junctions as well as proliferative, pro-inflammatory and anti-apoptotic nuclear responses (Backert et al, 2010). |
| UniProt ID | B2UTT2 |
| KEGG ID | hps:HPSH_04145 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | CagA [PF03507], Evalue: 2.5e-85, Aligned region: 865..1039 |
| Protein Sequence: 1161 a.a. [Download] |
| >gi|188527607|ref|YP_001910294.1| cag pathogenicity island protein CagA [Helicobacter pylori Shi470] MANETINQTKNPDQTPNQTAFDPQQFINNLQVAFIKVDSAVASFDPDQKPIVDKNDRDNRQAFNGISQLR EEYANKAIKNPNKKNQYFSDFINKSNDLINKDNLIDTDSSTKSFQKFGPEPYQIFMNWVSHQKDPSKINT QKIRDFMENIIQPPISDDKEKAEFLRSAKQSFAGIIIGNQTRSDEKFMGVFEESLKEKQEAEKKGEPSGD WLDIFLSFVFNKKQSSDLKETLNQEPRPNVEQNIATTPTPIQGLPLEARDLLDERGDFSKFTLGDMEMLD VEGVADIDPNYKFNQLLIHNNALSSMLMGSHGNIDLEKVSLLYGDNGGPEARHDWNATVGYKNQQGNNVA TLINAHLKNGSGLIIAGNENGINNPSFYLYKKDQLTGLEQALSQEEIQNKLGFMEFLAQNSARHVGLNNL SKEEKEKFQTEIGNFQKDPKAYLDTLGSDHIAFVSKKDQKHLALVTEFGNGELSYTLKDYGKKPDRALDR ETKTTLQGNLKDDGVMFVNYSNFKYTNASKSPNEGIGATNGVSHLEANFSKVAVFNLPDLNGLAVSSFAR RNLEDKLAAKGLSGKESNKLIKDFLSSNKELLEKVLNFNKAVAEAKNTGNYDGVKKAQKDLEKSIRKRER LEKEITKQFESKSGNKNKMEAKAQANSQKDEIFKLINEGAYKEARIIAYAQNLKGIRRELSDRMGNINKN LKDFNQSFDALKSGKNKDFSKVEETLKALKSSVKDLNINPEWISKVENLNVALNEFKNGKNKDFSKVTQA KSDLENSIKDVHINQQITDKVDNLNQAVLVAKATGDFSRVEQALAGFKKFLTDQKNENFNVGKNSDLQSV KNGVNGTLVGNGLSVTEATTLTKKFSDIKKELNEKFANFNKNSNGLKNSAEPIYAQVNKKKTGQVASPEE SIYTQVAKEVNEKINRLNEKASASKGVGNFSGAGRLDSPEPIYATIDDLGGSSPLKRHAKVDDLSKVGLS REQELTQKIGNLNQAVSEAKAGSFGNLERTMDGLKDSTKKNVVNLWFEGARKVPISLQAKLDNYATNSHT RINSNVKNGTINEKATIMLTQKNPEWLKLVNDKIVAHNVGSTPLSDYDKIGFNQKNMKDYSDSFKFSIKL SNAVKNIKSGFVQCLTDCISAGSYSPKKAEHGVTKSGFQKS |
| - |
| Nucleotide Sequence: 3486 bp [Download] |
| >gi|209406223|ref|NC_010698.2|:c807594-804109 Helicobacter pylori Shi470 chromosome, complete genome ATGGCTAACGAAACCATCAATCAAACAAAAAATCCAGATCAAACACCAAACCAAACGGCTTTTGATCCAC AACAATTTATCAATAATCTTCAAGTGGCTTTCATTAAAGTTGATAGCGCTGTCGCTTCATTTGATCCCGA TCAAAAACCAATCGTTGATAAGAACGATAGGGATAACAGGCAAGCTTTTAATGGAATCTCGCAATTAAGG GAAGAATACGCCAATAAAGCGATCAAAAATCCCAACAAAAAGAATCAGTATTTTTCAGACTTTATCAATA AGAGCAATGATTTGATCAACAAAGACAATCTCATTGATACAGATTCTTCCACAAAGAGCTTTCAGAAATT TGGGCCTGAGCCTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAGATCCGTCTAAAATCAACACC CAAAAAATCCGAGATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAAAAAGCGGAGT TTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAACCAAACCCGATCGGATGAAAAATT CATGGGCGTGTTTGAAGAATCTTTGAAAGAGAAGCAAGAAGCAGAAAAAAAAGGAGAGCCTAGTGGGGAT TGGCTTGATATTTTTTTATCGTTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATC AAGAGCCAAGGCCTAATGTTGAACAAAATATAGCCACTACCCCCACCCCCATACAAGGCTTACCGCTTGA AGCTAGGGATTTGCTTGATGAAAGGGGTGATTTTTCTAAATTCACTCTTGGTGATATGGAAATGTTGGAT GTTGAGGGTGTCGCCGACATTGATCCTAATTACAAGTTCAACCAGTTATTGATTCACAATAACGCTCTGT CTTCTATGCTAATGGGGAGTCATGGCAACATAGATCTTGAAAAAGTTTCATTGTTGTATGGGGATAATGG TGGCCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCAACAATGTGGCC ACACTCATCAATGCACATCTTAAAAACGGCAGTGGGTTAATCATAGCGGGTAATGAAAATGGGATTAACA ACCCTAGCTTCTATCTCTACAAAAAAGACCAACTCACAGGCTTGGAACAAGCGTTGAGTCAAGAAGAGAT CCAAAACAAACTAGGTTTCATGGAATTTCTTGCACAAAACAGCGCTAGACATGTTGGATTAAATAACTTG AGCAAGGAAGAGAAAGAAAAGTTCCAAACTGAAATTGGAAATTTCCAAAAAGACCCTAAGGCTTATTTAG ACACCCTAGGGAGTGATCACATTGCTTTTGTTTCTAAAAAAGACCAAAAGCATTTAGCTTTGGTTACTGA GTTTGGCAATGGGGAATTGAGCTATACCCTCAAAGATTATGGGAAAAAACCAGATAGAGCTTTAGATAGG GAGACAAAAACCACTCTTCAAGGTAACCTAAAAGATGATGGCGTGATGTTTGTCAATTATTCCAATTTCA AATACACCAACGCCTCCAAGAGTCCTAATGAGGGTATAGGCGCTACGAATGGCGTTTCCCATTTGGAAGC AAATTTTAGCAAGGTAGCTGTCTTTAATTTGCCTGATTTAAATGGTCTCGCTGTCTCTAGTTTTGCAAGG CGGAATTTAGAGGATAAACTGGCCGCTAAAGGATTGTCCGGAAAAGAATCTAATAAGCTCATCAAAGACT TTTTGAGCAGCAACAAGGAATTGCTTGAAAAAGTTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAA TACAGGCAATTATGATGGGGTGAAAAAAGCTCAAAAAGATCTTGAAAAATCTATAAGGAAACGAGAGCGT TTAGAGAAAGAAATAACGAAACAATTTGAGAGCAAGAGCGGCAACAAAAATAAAATGGAAGCAAAAGCTC AAGCTAACAGCCAAAAAGATGAGATTTTTAAGCTTATCAATGAAGGGGCTTATAAGGAAGCAAGAATCAT CGCTTACGCTCAGAATCTTAAAGGCATCAGGAGGGAATTGTCTGATAGAATGGGAAATATCAACAAGAAT TTGAAAGACTTTAATCAATCTTTTGATGCGCTCAAAAGTGGTAAAAATAAGGATTTCAGCAAGGTAGAAG AAACGCTAAAAGCCCTTAAAAGCTCGGTGAAAGATTTGAATATCAATCCAGAATGGATTTCAAAAGTTGA AAACCTTAATGTAGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCA AAAAGCGACCTTGAAAATTCCATTAAGGATGTGCACATCAATCAACAGATAACGGATAAAGTTGACAATC TCAATCAGGCTGTATTAGTGGCTAAAGCGACAGGCGATTTCAGTAGGGTAGAGCAAGCGCTAGCCGGATT CAAAAAATTCTTAACGGATCAAAAAAATGAAAATTTCAATGTTGGAAAAAATTCTGATCTACAATCCGTT AAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGATTATCTGTAACAGAAGCCACAACGCTCACCAAAA AATTTTCGGACATTAAGAAAGAATTGAATGAGAAATTTGCAAATTTCAACAAAAATAGTAATGGACTCAA AAACAGCGCAGAGCCCATTTACGCTCAAGTTAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAG TCCATTTACACTCAAGTTGCTAAAGAGGTAAATGAAAAAATTAACCGACTCAACGAAAAAGCATCAGCAA GTAAAGGAGTGGGCAATTTTAGTGGAGCAGGGCGATTAGATAGCCCTGAACCCATTTACGCTACGATTGA TGATCTCGGCGGATCTTCCCCTTTGAAAAGGCATGCTAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCA AGGGAGCAAGAATTGACTCAGAAAATTGGCAATCTCAATCAGGCAGTGTCAGAAGCTAAAGCAGGTTCTT TTGGCAACCTAGAACGAACGATGGATGGACTCAAAGATTCTACAAAAAAGAATGTTGTGAATCTATGGTT TGAAGGTGCAAGAAAAGTGCCTATTAGTTTGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACA CGCATTAATAGCAATGTCAAAAATGGAACAATCAATGAAAAAGCGACCATCATGCTAACGCAAAAAAACC CTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGCACTCCTTTGTCAGATTA TGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTACTCTGATTCGTTCAAGTTTTCCATCAAGTTG AGTAATGCCGTAAAAAACATTAAGTCTGGCTTTGTGCAATGTTTAACCGATTGCATTTCTGCAGGATCTT ACAGCCCAAAGAAAGCGGAACATGGAGTTACAAAAAGTGGTTTCCAGAAATCTTAA |
| Reference |
(1) Delgado-Rosado G; Dominguez-Bello MG; Massey SE (2011). Positive selection on a bacterial oncoprotein associated with gastric cancer. Gut Pathog. 3:18. [PudMed:22078307] 
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| experimental literature |