| Effector Protein ID: 17987499 |
 T4SS name [ID] | VirB [1] |
| Gene symbol | - |
| Locus tag | BMEI1216 |
| Strain | Brucella melitensis bv. 1 str. 16M |
| Replicon | chromosome II [GenBank: NC_003317] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1264446..1264982 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | BtpB |
| T4CP requirement | T4CP Indepedent |
| Target/Effection | BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells.BtpB plays a major role in the modulation of host innate immune response during infection. |
| UniProt ID | Q8YGE3 |
| KEGG ID | bme:BMEI1216 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | TIR_2 [PF13676], Evalue: 3.7e-07, Aligned region: 45-172 |
| Protein Sequence: 178 a.a. [Download] |
| >gi|17987499|ref|NP_540133.1| hypothetical protein BMEI1216, partial [Brucella melitensis bv. 1 str. 16M] MNRTHWAVKDVNLPKELHTAKGITLPSWTRQASRAVDITQHDFDVGLSFPGEARGLVEQVARELEARVGP NAYFYDNNYVSQLARPSLDTLLQDIYRNRCKLIVVFVGDDYQRKDRCGVEFRAIREIIMARAEQRIMFVR VDDGAVDGVFRTDGYVDARRFNPSEIAQFIAERVALIT |
| - |
| Nucleotide Sequence: 537 bp [Download] |
| >gi|17986284|ref|NC_003317.1|:c1264982-1264446 Brucella melitensis bv. 1 str. 16M chromosome I, complete sequence ATGAATCGTACGCACTGGGCGGTCAAAGACGTAAACCTGCCCAAGGAGCTGCACACGGCCAAAGGAATAA CTCTGCCGTCGTGGACGCGACAGGCGAGCCGTGCCGTCGATATCACTCAGCACGATTTTGACGTCGGTCT CTCTTTTCCCGGTGAGGCACGCGGGCTGGTCGAGCAAGTGGCCCGCGAACTCGAGGCACGCGTCGGTCCA AACGCCTATTTTTACGACAACAATTATGTTTCCCAGCTTGCCCGACCGTCGCTCGACACCCTACTTCAGG ACATCTACCGCAACCGCTGCAAACTGATCGTAGTCTTCGTCGGCGACGACTATCAGCGAAAAGACCGGTG CGGCGTCGAGTTCCGCGCGATTCGCGAAATCATCATGGCACGGGCCGAACAACGGATCATGTTCGTGCGT GTGGACGATGGCGCTGTCGATGGCGTGTTTCGCACGGACGGCTACGTGGATGCGAGACGGTTCAATCCTT CTGAGATCGCCCAGTTCATCGCCGAGCGCGTCGCCCTCATCACCTAG |
| Reference |
(1) Salcedo SP et al. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
. Front. Cell. Infect. Microbiol.
. 2013.00028
. [PudMed:23847770] 
|
| experimental literature |