| Effector Protein ID: 17987019 |
 T4SS name [ID] | VirB [1] |
| Gene symbol | - |
| Locus tag | BMEI0736 |
| Strain | Brucella melitensis bv. 1 str. 16M |
| Replicon | chromosome II [GenBank: NC_003317] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 762720..763247 [+] |
| Product | ferripyochelin binding protein |
| Effector type | Protein |
| Descripton | RicA |
| T4CP requirement | T4CP Indepedent |
| Target/Effection | RicA was demonstrated to interact with human small GTPase Rab2 involved in trafficking |
| UniProt ID | Q8YHR0 |
| KEGG ID | bme:BMEI0736 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Hexapep [PF00132], Evalue: 2.6e-19, Aligned region: 17..47 Hexapep [PF00132], Evalue: 2.6e-19, Aligned region: 75..105 Hexapep [PF00132], Evalue: 2.6e-19, Aligned region: 90..124 |
| Protein Sequence: 175 a.a. [Download] |
| >gi|17987019|ref|NP_539653.1| ferripyochelin binding protein [Brucella melitensis bv. 1 str. 16M] MPIYAYNGHKPQFADRESNWIAPDATLIGKVVVGENAGFWFGAVLRGDNEPITIGADTNVQEQTIMHTDI GFPLTIGAGCTIGHRAILHGCTIGENTLIGMGAIVLNGAKVGKNCLIGAGTLVKEGMEIPDNSLVVGSPA RVLRQLDDAAVEKLRASAKHYVERGHSFMRGMEPA |
| - |
| Nucleotide Sequence: 528 bp [Download] |
| >gi|17986284|ref|NC_003317.1|:762720-763247 Brucella melitensis bv. 1 str. 16M chromosome I, complete sequence ATGCCGATCTATGCATATAACGGGCACAAGCCGCAGTTTGCGGACCGCGAGAGCAACTGGATTGCACCGG ATGCGACGCTGATCGGCAAGGTGGTCGTGGGCGAGAATGCGGGTTTCTGGTTCGGCGCGGTGTTGCGCGG CGATAATGAGCCAATCACTATCGGTGCCGATACCAATGTGCAGGAACAGACGATCATGCACACCGATATC GGCTTTCCGCTGACCATCGGTGCGGGCTGCACTATCGGGCACCGTGCGATTCTCCATGGCTGCACGATTG GCGAGAATACTCTTATCGGCATGGGCGCGATTGTGCTCAATGGCGCGAAGGTCGGCAAGAATTGCCTTAT CGGGGCGGGAACATTGGTGAAAGAAGGGATGGAAATCCCTGATAATTCGCTTGTTGTCGGCTCTCCCGCG CGTGTCCTGCGCCAGCTTGACGATGCTGCCGTTGAAAAGCTGCGGGCCTCTGCAAAGCATTATGTGGAGA GGGGACATTCCTTCATGCGCGGCATGGAGCCTGCCTGA |
| Reference |
| (1) von Bargen K; Gorvel JP; Salcedo SP (2012). Internal affairs: investigating the Brucella intracellular lifestyle. FEMS Microbiol Rev. 36(3):533-62. [PudMed:22373010] |
(2) de Barsy M; Jamet A; Filopon D; Nicolas C; Laloux G; Rual JF; Muller A; Twizere JC; Nkengfac B; Vandenhaute J; Hill DE; Salcedo SP; Gorvel JP; Letesson JJ; De Bolle X (2011). Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. Cell Microbiol. 13(7):1044-58. [PudMed:21501366] 
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| experimental literature |