| Effector Protein ID: 163868792 |
 T4SS name [ID] | VirB [225] |
| Gene symbol | bepI |
| Locus tag | Btr_1710 |
| Strain | Bartonella tribocorum CIP 105476 |
| Replicon | chromosome [GenBank: NC_010161] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1823441..1825813 [+] |
| Product | BepI protein |
| Effector type | Protein |
| Descripton | BepI |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Homologous to BepA protein BepC protein and BepG protein of Bartonella henselae. The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. |
| UniProt ID | A9IWQ5 |
| KEGG ID | btr:Btr_1710 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Fic [PF02661], Evalue: 6.2e-15, Aligned region: 81..192 |
| Protein Sequence: 790 a.a. [Download] |
| >gi|163868792|ref|YP_001610016.1| BepI protein [Bartonella tribocorum CIP 105476] MKENTEQSASSTEELQEHPPAINAAISKKINEEAQNFFYPNSKVLKNKYRIKDKEILMERCSDDVKKEMI KLRQEPPPEQFNSSYLKYLHQRLFSRAFEWAGQTRQAPFTFADSSVASMPILKRKEFTQPFAIGRKVQEG LEKLDKTLAEKNNLKGLSREEFVEHAAQLMIDLHHLHPFREGNRRTKRLFVEKLGQAAGHELNFSLVSKK RKNFVRAAAMERGDPEPMKHLLEDISHPEKSLILQEFTDSMKKLGMGEKNYYLAVVAKEGETYHGTYRGC GNKGFMMDAQGTLILGNKKDLTPEQRQTLTIGEAFSFTAPKAQSLQKIQLPEDKRAAPKNDEITEKRKDN ASIHTKRKVKAHFAPWTASHALQDSVEVMPQSLPEKEQMAQPMAQSFSAEQRQKKFQETILQTNNRTTND QISVQITKEKHSDHQERAKQHPKKAMVYWDIATKKTETASLPSSEKLSLSPETKEERTPEQRQTLKKGDL LSFTAPRPQYQQEMLIPAEKIPPLTSDEIITRIKNNASLQERRTEIQTLCQIVYGNRHILQEKIERIHEN RTEGEQLTYQIATSPQSIAKFSGSNRFGIKNNARTNAEANILPLCRAIECYIDIFKQTERDILHDHHAKQ RRCKQAVEMPEAWMQNLLSLPKEQQKETLSNSPELRGEIRDYIRKINERLSSSEHEAIKESNSEKLAKSL GTSAVKAKEILAIVKQTKEIEHNIHSMDFYDRKLNECSAPNQRQSIQHQLIKKNTEKICLNTLDKEASKA QKVTENIQSYKTQYTKAMTL |
| - |
| Nucleotide Sequence: 2373 bp [Download] |
| >gi|163867306|ref|NC_010161.1|:1823441-1825813 Bartonella tribocorum CIP 105476 chromosome, complete genome ATGAAAGAAAACACAGAACAGAGTGCCTCCTCCACAGAAGAATTGCAAGAACACCCCCCTGCAATTAATG CCGCCATTTCTAAGAAAATCAATGAAGAAGCGCAAAATTTTTTCTACCCCAATAGCAAGGTGCTTAAAAA TAAATACCGCATCAAAGATAAAGAAATATTAATGGAACGGTGTTCTGATGATGTCAAAAAAGAAATGATC AAACTGCGTCAAGAACCTCCCCCAGAACAGTTTAATTCCTCCTATCTAAAATATCTTCATCAACGTCTTT TTTCCCGTGCATTTGAATGGGCAGGACAAACCCGCCAAGCACCTTTTACCTTTGCAGATAGCAGTGTTGC TTCCATGCCCATTTTGAAAAGAAAAGAATTTACACAACCTTTTGCAATTGGCAGAAAAGTACAGGAGGGA CTAGAAAAGTTAGATAAAACACTTGCTGAAAAAAATAATTTAAAAGGCTTATCCCGCGAAGAATTTGTTG AACATGCTGCTCAACTGATGATAGATCTACACCACTTGCATCCTTTCAGAGAGGGTAATAGGCGCACAAA AAGACTGTTTGTTGAAAAACTTGGGCAAGCCGCAGGACATGAACTAAACTTTTCACTTGTGAGTAAAAAA CGCAAAAACTTTGTCCGCGCGGCCGCCATGGAACGTGGCGATCCAGAGCCCATGAAGCATCTGCTTGAGG ATATCTCCCATCCAGAAAAATCGCTCATTTTACAAGAATTCACCGACTCTATGAAAAAGCTTGGAATGGG TGAAAAAAATTATTATCTCGCTGTCGTCGCAAAAGAAGGAGAAACCTATCATGGGACCTATAGAGGCTGT GGAAACAAGGGCTTTATGATGGATGCTCAGGGAACTCTTATCTTGGGAAATAAAAAAGATCTCACCCCAG AACAAAGACAAACATTAACAATTGGTGAGGCCTTTTCCTTTACAGCACCAAAGGCTCAAAGCCTGCAAAA AATACAGCTTCCAGAAGACAAAAGAGCCGCTCCCAAAAACGATGAAATCACTGAAAAGCGCAAAGACAAC GCATCCATTCACACAAAAAGAAAGGTAAAAGCTCATTTTGCACCATGGACTGCCTCTCATGCTTTACAGG ACAGCGTTGAAGTTATGCCCCAAAGTCTACCAGAAAAAGAACAAATGGCACAGCCAATGGCGCAATCTTT TTCTGCGGAGCAAAGGCAAAAAAAATTCCAAGAAACCATTTTACAGACCAACAATAGAACAACAAATGAT CAAATATCTGTCCAAATAACAAAGGAAAAACACTCTGATCATCAAGAAAGAGCAAAACAACACCCCAAAA AAGCAATGGTATACTGGGACATTGCTACAAAGAAAACGGAAACCGCCTCTCTCCCCTCATCTGAGAAATT ATCCTTATCGCCTGAAACCAAAGAAGAGCGCACACCAGAACAAAGACAAACATTAAAAAAAGGTGATCTC CTCTCCTTTACTGCACCAAGACCTCAATACCAGCAAGAAATGCTGATCCCCGCAGAAAAAATACCTCCTC TTACAAGCGACGAAATTATCACAAGAATAAAAAACAACGCATCACTTCAAGAAAGAAGAACAGAAATCCA AACTCTATGCCAAATCGTTTACGGCAATCGGCATATTTTGCAGGAAAAAATTGAGAGAATCCATGAAAAT CGCACGGAGGGAGAACAGCTCACTTATCAAATTGCCACATCTCCTCAATCGATTGCTAAGTTTTCTGGAA GCAATAGATTTGGCATAAAAAATAACGCGCGCACCAATGCTGAAGCAAATATTTTACCCCTCTGTAGAGC CATTGAGTGTTATATCGATATTTTTAAACAAACAGAAAGAGACATTCTCCATGACCATCACGCAAAACAA AGGCGCTGTAAACAAGCGGTAGAAATGCCTGAAGCGTGGATGCAAAATCTCCTGTCCTTGCCAAAAGAAC AGCAGAAAGAAACGTTATCAAACTCTCCTGAATTAAGAGGAGAAATAAGGGATTATATCAGAAAAATCAA TGAACGTTTATCCTCAAGCGAGCATGAAGCGATAAAGGAAAGCAATTCCGAAAAACTAGCTAAGAGTCTT GGTACATCAGCCGTCAAAGCAAAAGAGATTCTGGCAATCGTCAAGCAAACAAAAGAGATAGAACATAACA TACACTCCATGGATTTTTATGACCGCAAATTGAATGAGTGTTCAGCGCCAAACCAACGTCAATCCATCCA GCATCAGTTGATAAAGAAAAACACTGAAAAAATATGTTTGAATACGCTTGATAAAGAAGCAAGTAAAGCG CAGAAAGTAACAGAAAATATTCAATCATACAAAACGCAGTACACAAAAGCCATGACTCTCTAA |
| Reference |
(1) Saenz HL; Engel P; Stoeckli MC; Lanz C; Raddatz G; Vayssier-Taussat M; Birtles R; Schuster SC; Dehio C (2007). Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors. Nat Genet. 39(12):1469-76. [PudMed:18037886] 
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| experimental literature |