| Effector Protein ID: 15645173 |
 T4SS name [ID] | Cag [4] |
| Gene symbol | - |
| Locus tag | HP0547 |
| Strain | Helicobacter pylori 26695 |
| Replicon | chromosome [GenBank: NC_000915] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 579921..583481 [+] |
| Product | cag pathogenicity island protein (cag26) |
| Effector type | Protein |
| Descripton | CagA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | CagA can cause gastritis and peptic ulcer, Injected CagA can act as a ‘master key’ that evolved the ability to highjack multiple host cell signalling cascades, which include the induction of membrane dynamics, actin-cytoskeletal rearrangements and the disruption of cell-to-cell junctions as well as proliferative, pro-inflammatory and anti-apoptotic nuclear responses (Backert et al, 2010). |
| UniProt ID | P55980 |
| KEGG ID | hpy:HP0547 |
| PDB ID | 4DVZ, 4DVY, 3IEC |
| Domain hit(s) vs Pfam | CagA [PF03507], Evalue: 8.2e-120, Aligned region: 869..1058 |
| Protein Sequence: 1186 a.a. [Download] |
| >gi|15645173|ref|NP_207343.1| cag pathogenicity island protein (cag26) [Helicobacter pylori 26695] MTNETIDQTRTPDQTQSQTAFDPQQFINNLQVAFIKVDNVVASFDPDQKPIVDKNDRDNRQAFDGISQLR EEYSNKAIKNPTKKNQYFSDFIDKSNDLINKDNLIDVESSTKSFQKFGDQRYQIFTSWVSHQKDPSKINT RSIRNFMENIIQPPIPDDKEKAEFLKSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGGPTGG DWLDIFLSFIFNKKQSSDVKEAINQEPVPHVQPDIATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEML DVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYAGNGGFGDKHDWNATVGYKDQQGNNV ATLINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIRNKVDFMEFLAQNNTKLDNLSE KEKEKFQNEIEDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFNNGDLSYTLKDYGKKADKALDREK NVTLQGSLKHDGVMFVDYSNFKYTNASKNPNKGVGATNGVSHLEAGFNKVAVFNLPDLNNLAITSFVRRN LENKLTAKGLSLQEANKLIKDFLSSNKELAGKALNFNKAVAEAKSTGNYDEVKKAQKDLEKSLRKREHLE KEVEKKLESKSGNKNKMEAKAQANSQKDEIFALINKEANRDARAIAYTQNLKGIKRELSDKLEKISKDLK DFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKS DLENSVKDVIINQKVTDKVDNLNQAVSVAKAMGDFSRVEQVLADLKNFSKEQLAQQAQKNEDFNTGKNSE LYQSVKNSVNKTLVGNGLSGIEATALAKNFSDIKKELNEKFKNFNNNNNGLKNSTEPIYAKVNKKKTGQV ASPEEPIYTQVAKKVNAKIDRLNQIASGLGGVGQAAGFPLKRHDKVDDLSKVGLSASPEPIYATIDDLGG PFPLKRHDKVDDLSKVGRSRNQELAQKIDNLNQAVSEAKAGFFGNLEQTIDKLKDSTKKNVMNLYVESAK KVPASLSAKLDNYAINSHTRINSNIQNGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSVSLSEYDKIG FNQKNMKDYSDSFKFSTKLNNAVKDIKSGFTHFLANAFSTGYYCLARENAEHGIKNVNTKGGFQKS |
| - |
| Nucleotide Sequence: 3561 bp [Download] |
| >gi|15644634|ref|NC_000915.1|:579921-583481 Helicobacter pylori 26695 chromosome, complete genome ATGACTAACGAAACTATTGATCAAACAAGAACACCAGATCAAACACAAAGCCAAACAGCTTTTGATCCGC AACAATTTATCAATAATCTTCAAGTGGCTTTTATTAAAGTTGATAATGTTGTCGCTTCATTTGATCCTGA TCAAAAACCAATCGTTGATAAGAACGATAGGGATAACAGGCAAGCTTTTGATGGAATCTCGCAATTAAGG GAAGAATACTCCAATAAAGCGATCAAAAATCCTACCAAAAAGAATCAGTATTTTTCAGACTTTATCGATA AGAGCAATGATTTAATCAACAAAGACAATCTCATTGATGTAGAATCTTCCACAAAGAGCTTTCAGAAATT TGGGGATCAGCGTTACCAAATTTTCACAAGTTGGGTGTCCCATCAAAAAGATCCGTCTAAAATCAACACC CGATCGATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCCCTGATGATAAAGAAAAAGCAGAGT TTTTGAAATCTGCCAAACAATCTTTTGCAGGAATCATTATAGGGAATCAAATCCGAACGGATCAAAAGTT CATGGGCGTGTTTGATGAATCCTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGGGCCTACTGGTGGG GATTGGTTGGATATTTTTCTCTCATTTATATTTAACAAAAAACAATCTTCCGATGTCAAAGAAGCAATCA ATCAAGAACCAGTTCCCCATGTCCAACCAGATATAGCCACTACTACCACCGACATACAAGGCTTACCGCC TGAAGCTAGGGATTTACTTGATGAAAGGGGTAATTTTTCTAAATTCACTCTTGGCGATATGGAAATGTTA GATGTTGAGGGAGTCGCTGACATTGATCCTAATTACAAGTTCAATCAATTATTGATTCACAATAACGCTC TGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGCGGGCAA TGGTGGTTTTGGAGACAAACACGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTG GCTACACTCATTAATGTGCATATGAAAAACGGCAGTGGCTTAGTCATAGCAGGTGGTGAGAAAGGGATTA ATAACCCTAGTTTTTATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGTCAAGAAGA GATCCGAAACAAAGTAGATTTCATGGAATTTCTTGCACAAAATAATACTAAATTAGACAACTTGAGCGAG AAAGAGAAAGAAAAATTCCAAAATGAGATTGAAGATTTTCAAAAAGACTCTAAGGCTTATTTAGACGCCC TAGGGAATGATCGTATTGCTTTTGTTTCTAAAAAAGACACAAAACATTCAGCTTTAATTACTGAGTTTAA TAATGGGGATTTGAGCTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCTTTAGATAGGGAGAAA AATGTTACTCTTCAAGGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAAATACA CCAACGCCTCCAAGAATCCCAATAAGGGTGTAGGCGCTACGAATGGCGTTTCCCATTTAGAAGCAGGCTT TAACAAGGTAGCTGTCTTTAATTTGCCTGATTTAAATAATCTCGCTATCACTAGTTTCGTAAGGCGGAAT TTAGAGAATAAACTAACCGCTAAAGGATTGTCCCTACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGA GCAGCAACAAAGAATTGGCTGGAAAAGCTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAGCACAGG CAACTATGACGAGGTGAAAAAAGCTCAGAAAGATCTTGAAAAATCCCTAAGGAAACGAGAGCATTTGGAG AAAGAAGTAGAGAAAAAATTGGAGAGCAAAAGCGGCAACAAAAATAAAATGGAAGCAAAAGCTCAAGCTA ACAGCCAAAAAGATGAGATTTTTGCGTTGATCAATAAAGAGGCTAATAGGGATGCAAGAGCAATCGCTTA CACTCAAAATCTTAAAGGCATCAAAAGGGAATTGTCTGATAAACTTGAAAAAATCAGCAAGGATTTGAAA GACTTTAGTAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACGC TAAAAGCCCTTAAAGGCTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCT TAATGCAGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGC GACCTTGAAAATTCCGTTAAAGATGTGATCATCAATCAAAAGGTAACGGATAAAGTTGACAATCTCAATC AAGCGGTATCAGTGGCTAAAGCAATGGGCGATTTCAGTAGGGTAGAGCAAGTGTTAGCCGATCTCAAAAA CTTCTCAAAGGAGCAATTGGCTCAACAAGCTCAAAAAAATGAAGATTTCAATACTGGAAAAAATTCTGAA CTATACCAATCCGTTAAGAATAGTGTAAATAAAACCCTAGTCGGTAATGGGTTATCTGGAATAGAGGCCA CAGCTCTCGCCAAAAATTTTTCGGATATCAAGAAAGAATTGAATGAGAAATTTAAAAATTTCAATAACAA TAATAATGGACTCAAAAACAGCACAGAACCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGACAAGTA GCTAGCCCTGAAGAACCCATTTATACTCAAGTTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATC AAATAGCAAGTGGTTTGGGTGGTGTAGGGCAAGCAGCGGGCTTCCCTTTGAAAAGGCATGATAAAGTTGA TGATCTCAGTAAGGTAGGGCTTTCAGCTAGCCCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGA CCTTTCCCTTTGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCGATCAAGGAATCAAGAAT TGGCTCAGAAAATTGACAATCTCAATCAAGCGGTATCAGAAGCTAAAGCAGGTTTTTTTGGCAACCTAGA GCAAACGATAGACAAGCTCAAAGATTCTACAAAAAAGAATGTTATGAATCTATATGTTGAAAGTGCAAAA AAAGTGCCTGCTAGTTTGTCAGCGAAATTGGACAATTATGCTATTAACAGCCACACACGCATTAATAGCA ATATCCAAAATGGAGCAATCAATGAAAAAGCGACCGGTATGCTAACGCAAAAAAACCCTGAGTGGCTTAA GCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGCGTTTCTTTGTCAGAGTATGATAAAATTGGC TTCAACCAGAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCTGTAA AAGACATTAAGTCTGGCTTTACGCACTTTTTAGCCAATGCATTTTCTACAGGATATTACTGCTTGGCGAG GGAAAATGCGGAGCATGGAATCAAAAATGTTAATACAAAAGGTGGTTTCCAAAAATCTTAA |
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| experimental literature |