| Effector Protein ID: 154706008 |
 T4SS name [ID] | Dot/Icm [160] |
| Gene symbol | - |
| Locus tag | CBUD_2034 |
| Strain | Coxiella burnetii Dugway 5J108-111 |
| Replicon | chromosome [GenBank: NC_009727] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2009107..2010513 [-] |
| Product | ankyrin repeat protein |
| Effector type | Protein |
| Descripton | AnkA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Inhibits apoptosis |
| UniProt ID | A9KGV3 |
| KEGG ID | cbd:CBUD_2034 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 6.5e-21, Aligned region: 5..128 Ank_2 [PF12796], Evalue: 6.5e-21, Aligned region: 70..155 Ank_2 [PF12796], Evalue: 6.5e-21, Aligned region: 104..195 Ank_4 [PF13637], Evalue: 4.4e-10, Aligned region: 100..151 |
| Protein Sequence: 468 a.a. [Download] |
| >gi|154706008|ref|YP_001425340.1| ankyrin repeat protein [Coxiella burnetii Dugway 5J108-111] MLSLMASQSGNVDMMEWLINEKKQPLFVQKSTVPAGNDNAIENNGELKSDQVNSDSAKIPVQNSLREGPL QLAAREGRVAMVEWLVRQGLSLEYSDPTRNLVLIAATHERLNLLKWLEEKGLSLDVRDQNGNDPVLLASA NRDVLMLEWLVLEKELPLDSQNDQKLTALNHAVGKKYSNDFDNRHLATVLFIVDKLLRQGINLDCEGWSL LSWKMRASWLRSLAHQLNQDGFYEQAEIIYDVIWKKLETGEEKEKLGYQLASLILAGSSEQQEKIKIQKV LRTKNEKAASKSTMEEALSLDEDKTNKPPKTQEEAFASLLSEENLCLFASTLKTEDSVHRTLNEKIALQR RAARALSHIMENKDDASLELKGRLIENLKGNFSLQQAEGKEEKEKTYQPQTPIAAAHFLNNPPSSLSPPN LAEFYRLHLGDQLVQMQRILERNAELEEECRLKSGQQDENNYSGPGLF |
| - |
| Nucleotide Sequence: 1407 bp [Download] |
| >gi|154705721|ref|NC_009727.1|:c2010513-2009107 Coxiella burnetii Dugway 5J108-111 chromosome, complete genome TTGCTTAGCTTAATGGCCAGCCAATCGGGCAACGTTGATATGATGGAATGGTTGATAAATGAAAAAAAAC AACCTTTATTTGTTCAAAAATCAACAGTTCCCGCTGGAAACGACAACGCTATTGAAAATAATGGAGAGTT AAAAAGTGATCAAGTAAATAGCGATTCAGCGAAAATTCCTGTTCAAAACTCTCTTAGAGAGGGCCCATTG CAGTTGGCAGCCCGTGAGGGGCGTGTGGCTATGGTCGAGTGGCTTGTAAGGCAGGGTCTCTCTTTGGAGT ATTCCGACCCCACAAGGAATTTGGTGCTAATAGCAGCAACTCATGAGCGCTTGAACCTACTGAAGTGGCT TGAGGAGAAAGGACTGTCTTTGGATGTCAGGGATCAGAACGGTAATGACCCTGTACTACTGGCGTCAGCC AATAGGGATGTTCTAATGTTGGAATGGCTAGTGTTGGAAAAGGAGCTTCCCTTGGATAGCCAAAATGATC AGAAACTCACGGCGCTTAACCACGCCGTGGGCAAGAAGTATAGCAACGATTTTGACAATCGCCATTTGGC CACTGTGCTTTTTATCGTGGATAAGCTTTTGCGGCAAGGTATCAATCTTGATTGTGAGGGTTGGTCTCTT TTGAGTTGGAAAATGCGAGCTTCTTGGCTTAGGTCACTGGCGCATCAACTAAACCAAGATGGATTTTATG AACAAGCTGAAATCATTTATGATGTTATTTGGAAGAAGCTCGAAACAGGGGAAGAGAAGGAAAAACTGGG ATATCAATTGGCTTCCCTTATTTTGGCCGGAAGCTCGGAACAGCAAGAAAAGATAAAGATACAAAAAGTA TTACGGACAAAAAATGAAAAAGCCGCATCAAAAAGCACGATGGAAGAAGCGTTGTCGTTAGATGAAGATA AGACTAACAAGCCGCCAAAAACACAGGAGGAAGCTTTCGCCTCTCTCTTATCAGAAGAGAACCTTTGTCT CTTCGCAAGCACACTGAAAACAGAGGATAGTGTTCATCGTACCCTCAATGAGAAAATAGCGCTGCAACGA AGAGCTGCGAGAGCCCTGTCACATATTATGGAGAACAAGGACGATGCCTCTTTAGAGTTAAAGGGTAGGC TGATAGAAAACCTGAAAGGAAACTTTAGTTTGCAACAAGCGGAGGGGAAAGAAGAAAAAGAAAAAACATA CCAACCCCAGACCCCTATCGCCGCGGCTCACTTTCTCAACAACCCGCCGTCAAGCTTGAGCCCTCCAAAT CTCGCGGAGTTTTATCGCCTTCACTTAGGAGACCAGCTCGTCCAAATGCAGAGGATCTTGGAACGAAATG CGGAGTTGGAGGAAGAGTGCCGGTTAAAATCGGGACAACAAGACGAAAACAATTATTCAGGCCCCGGACT GTTTTAA |
| Reference |
| (1) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632] |
(2) Voth DE; Howe D; Beare PA; Vogel JP; Unsworth N; Samuel JE; Heinzen RA (2009). The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion. J Bacteriol. 191(13):4232-42. [PudMed:19411324] 
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(3) Pan X; Luhrmann A; Satoh A; Laskowski-Arce MA; Roy CR (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 320(5883):1651-4. [PudMed:18566289] 
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| experimental literature |
| in silico analysis literature |