| Effector Protein ID: 148361007 |
 T4SS name [ID] | Dot/Icm [42] |
| Gene symbol | sdhA |
| Locus tag | LPC_2967 |
| Strain | Legionella pneumophila str. Corby |
| Replicon | chromosome [GenBank: NC_009494] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 468751..473040 [-] |
| Product | Dot/Icm system substrate protein SdhA |
| Effector type | Protein |
| Descripton | SdhA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SdhA is critical for intracellular growth and functions to prevent host cell death. SdhA also functions to inhibit Legionella infection-induced type I interferon response. Besides, SdhA prevente bacterial DNA release and AIM2 inflammasome activation. |
| UniProt ID | A5IHL8 |
| KEGG ID | lpc:LPC_2967 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1429 a.a. [Download] |
| >gi|148361007|ref|YP_001252214.1| Dot/Icm system substrate protein SdhA [Legionella pneumophila str. Corby] MISEKIKLLESFKQNQFSKLIEKINSKILATLKSGHFNPRLAPYLEKMNKDGVPFTDFDLDPENISQIKK LINALYHARLAFLDLENIDIGNIKRTIPDLKLLYSNTIHQAYQAGYLITNLDVDLQEMFKEEIDLILPVI GKLQAFAGEHQECTKHLAESLKDFPISYKAGEVTGIALEQMQPRTGDWDYQFLTQFSAVLPGYIEKLTQY IQQYSSQIKEKEPTLNNEKLEELQNASLKLLNDLEHLKGNDFFISLKVLKYIHIIRNIITLATSSVEQMG HFSDSSQDVIRDNLAQLKYVVLPTLFGLVDKIEDNAMLKPGTLSIPLMEKIKPLYQLLIYYASKPVNFKE KGEELLSIEDSRFLALRLERTYQRIDEANKALFKIQKAQEALDNFYKILDTPPYNKQPIHQLPKEIKNQL ITYYKIISPYMMDVNPDLNILLIDSFQGPESWSSYLKKPWRWLRGTLPADHASFVLAQKEALQTLISKKK ATQQFHIELNRDLIESVHKQTNLVLFPYSEKTNVFLLDETKALNPANGATDKLKFRPEKGHNILVNPEDL TSEQALDLYQWYRNKREKFRVASKAYNEFITLLKKQTKTIAETEGRILHLNNLDKETKTRCRNLYNIFQP YFIDGIPPELRASAISFDKFLVHSFSNESSTYDAPAVDLFEKLDEHFQIYFTEIDLQWGKKSNQYLKWAQ EKFASENNSTELEHDEKLESRAHHLIKHTNFSKCIHEFRTELNQVISFFNNAMRAQLKQQPNGIPYPELQ DQNKELAQSEQVVAIKRIFNSLYHVEKIVVELEKLDTRSYESIYVYHLIQAYDHINEIKKLALKLAVDPH FKLIASELLEKAQTLIATIQEHSDAYQVSPLEVPYNQDIKYNALWYTLNAFYISPKHIRSLRNTNYLTTE ELNDLHLKAKKATVTVENIIKSSNSYFKLFLQTPAMYSLYREMTNKLNEFISTSHDAVMNNLDQFRSKIF TPMLMEADAWEDKLGLVPGTISGPLKTITDEYYKGLLHPLALHSKAHIRMICDKTPIDQRIKTTNKKLEN ATQHLDKIEKNYKHIIKLYEIIKTKGGKTTDDELIETYKKALYKLVKLQKRLPQNTDHDPKDYELDTLLN SELKEYEPKLTLIKPLIISSYHHYEGLKATYLMKANTAREKLSYLKELRSTQEQEDLLYIEEYTTESFNK QLDAFCNRHIGLQYTDKEYRTKLREYLLTFKESIIQRSKSAEDINLTIKNLLKEKIKNFERDNFEKYYHL DAVRVALAQFKNYFSLSTAAIEQNNSTFESEETLAKKTELINKLVDISEDGTLTPKERVDQISFHVKNPN FERIIMDYKQESYFSFTYLKQCILSLLEALCLYTPERRKLFNNLESSVKTQPKINELTKRFGLFAGNESA ISTESRAITPVSSVENNGTIELNQLAPST |
| - |
| Nucleotide Sequence: 4290 bp [Download] |
| >gi|295815281|ref|NC_009494.2|:c473040-468751 Legionella pneumophila str. Corby chromosome, complete genome ATGATTTCAGAAAAGATCAAGCTTTTAGAATCCTTTAAGCAAAACCAATTCTCTAAATTAATTGAAAAAA TTAATTCAAAAATCCTTGCGACTTTAAAAAGCGGACATTTCAACCCCAGACTAGCCCCCTACTTGGAAAA AATGAATAAAGACGGGGTTCCATTCACCGATTTTGATCTTGACCCGGAAAATATTTCTCAAATCAAGAAA CTCATTAACGCCCTTTACCATGCCCGTTTAGCTTTTCTGGATTTAGAGAATATTGACATAGGGAACATCA AACGAACTATCCCTGATCTCAAATTACTTTACAGCAACACGATTCACCAGGCCTATCAAGCCGGTTATCT AATCACTAACCTGGATGTTGATTTGCAGGAAATGTTCAAGGAAGAGATTGATCTTATTCTTCCTGTCATT GGAAAATTACAAGCTTTTGCTGGTGAACACCAGGAATGCACCAAGCATTTGGCAGAATCTTTGAAGGATT TTCCTATAAGCTATAAAGCAGGAGAAGTTACAGGCATTGCCTTAGAGCAAATGCAACCGAGAACAGGAGA TTGGGATTACCAATTCCTCACTCAATTCAGTGCCGTATTACCTGGTTATATAGAAAAATTAACTCAATAC ATTCAACAATACTCTTCGCAAATCAAAGAAAAAGAGCCTACTCTAAATAATGAAAAGCTGGAAGAGTTAC AAAACGCATCATTAAAATTACTAAATGACCTGGAACATCTGAAAGGGAATGACTTTTTTATATCCCTTAA AGTTTTAAAATACATTCACATTATCCGTAATATCATCACATTGGCGACAAGCTCTGTTGAACAAATGGGA CATTTCAGCGATTCATCTCAGGATGTCATTCGTGATAATTTGGCTCAATTAAAATACGTTGTATTACCTA CTTTATTTGGGTTAGTGGATAAAATTGAAGACAATGCCATGCTGAAGCCTGGTACACTGTCTATTCCGTT AATGGAAAAAATCAAACCTCTATACCAGCTTTTAATTTATTACGCATCCAAACCCGTCAATTTCAAAGAA AAAGGAGAAGAGTTACTCAGTATAGAGGACTCCCGTTTTCTCGCTTTAAGACTGGAAAGAACATATCAAC GAATTGATGAAGCTAACAAAGCCCTTTTTAAAATTCAAAAAGCGCAAGAAGCTCTGGATAATTTTTACAA AATATTGGACACCCCCCCCTATAATAAGCAACCCATACATCAATTACCGAAAGAAATTAAAAACCAACTG ATTACATATTACAAAATAATCAGTCCTTATATGATGGATGTGAATCCTGATCTCAATATTTTGTTGATCG ATAGTTTTCAGGGCCCGGAATCCTGGTCTTCTTATTTAAAGAAGCCGTGGCGTTGGTTAAGAGGCACTCT TCCAGCCGATCACGCCAGTTTTGTTTTAGCGCAAAAGGAAGCATTACAAACTTTAATTAGCAAAAAGAAA GCCACTCAACAATTTCATATCGAATTGAATAGAGACCTTATCGAATCTGTTCACAAACAAACAAATCTGG TTTTATTCCCTTATAGTGAAAAAACGAATGTCTTTCTTCTAGATGAGACAAAAGCACTAAACCCTGCTAA TGGCGCTACGGACAAACTAAAATTCAGGCCAGAGAAGGGACATAATATACTGGTTAATCCTGAAGATTTA ACATCTGAACAGGCTCTTGACCTCTATCAATGGTATAGAAACAAACGTGAGAAATTCAGAGTTGCCAGCA AAGCATATAATGAATTTATTACCTTATTAAAAAAGCAAACCAAGACAATCGCTGAAACGGAAGGCAGGAT TCTCCATTTAAATAATCTTGATAAAGAGACCAAAACTCGCTGCCGTAATTTATATAATATATTTCAACCT TATTTTATCGATGGGATACCTCCTGAACTCAGAGCTTCCGCAATAAGTTTTGACAAATTTTTGGTTCATT CCTTTTCTAATGAGTCATCCACCTATGATGCCCCGGCAGTTGACCTGTTTGAAAAACTGGATGAACATTT TCAAATTTATTTTACAGAAATTGATTTACAATGGGGTAAAAAGAGTAATCAATATTTAAAATGGGCCCAG GAAAAATTTGCCAGTGAAAATAACTCAACCGAACTTGAACATGATGAAAAACTGGAAAGCAGAGCCCATC ATTTAATTAAACATACCAATTTCTCTAAATGCATACATGAGTTCAGAACGGAGCTTAATCAAGTCATTTC GTTTTTTAATAATGCGATGAGGGCGCAATTAAAACAACAACCCAATGGAATACCTTACCCTGAATTGCAA GATCAAAATAAAGAGCTTGCCCAGAGTGAACAGGTTGTTGCGATAAAACGCATATTCAATAGCCTCTATC ATGTTGAAAAGATTGTTGTTGAACTGGAAAAACTGGACACCAGAAGTTACGAAAGCATTTATGTCTATCA TTTAATACAAGCCTATGATCACATTAATGAAATTAAGAAATTAGCGCTAAAACTCGCTGTGGATCCTCAT TTTAAGCTCATAGCAAGCGAGTTACTGGAAAAAGCGCAAACTCTTATTGCAACAATACAAGAACACAGTG ATGCGTATCAGGTATCCCCGTTAGAAGTACCTTATAACCAGGATATTAAATACAATGCTCTCTGGTATAC ACTCAATGCTTTTTATATTTCACCAAAACACATTAGAAGTTTAAGAAATACCAACTATCTCACGACAGAA GAACTCAACGACTTACACTTAAAGGCAAAAAAAGCAACCGTTACTGTAGAAAATATCATTAAAAGTTCAA ACTCCTATTTCAAATTATTCTTACAAACGCCTGCCATGTATTCTCTCTATAGAGAAATGACGAACAAACT GAATGAATTTATTAGCACATCACATGACGCCGTAATGAATAATCTGGATCAATTCCGCTCCAAGATTTTT ACACCCATGCTGATGGAAGCGGACGCATGGGAAGATAAATTAGGCTTGGTACCAGGTACTATCTCAGGAC CATTAAAAACAATAACGGATGAATATTATAAAGGCCTGTTACATCCTTTAGCGCTGCATTCCAAAGCACA TATTCGAATGATATGTGATAAAACACCAATAGATCAAAGAATAAAAACAACGAATAAAAAACTCGAAAAT GCAACACAACATTTGGATAAAATAGAAAAAAATTATAAACATATCATCAAGCTATATGAAATTATCAAAA CAAAAGGCGGCAAAACCACTGATGATGAATTAATCGAAACTTATAAAAAAGCTCTGTACAAATTGGTAAA ATTACAAAAGCGATTACCCCAGAATACAGATCATGATCCTAAAGATTATGAATTAGACACTCTTTTAAAT TCAGAGCTGAAAGAGTATGAACCTAAATTAACGCTCATTAAGCCTCTCATTATCTCAAGCTACCATCATT ATGAAGGCCTAAAAGCCACTTATCTTATGAAAGCAAATACTGCCAGAGAAAAGTTGAGTTATCTTAAAGA GTTACGATCGACTCAGGAACAAGAAGATCTCCTTTATATAGAAGAATACACTACAGAATCATTTAATAAA CAATTAGATGCTTTCTGCAACCGTCATATCGGTTTACAATACACTGACAAGGAATATCGCACAAAACTTA GAGAATATTTACTGACATTCAAAGAAAGTATTATTCAACGCTCAAAATCCGCAGAAGATATTAATTTAAC TATAAAAAATTTGCTAAAGGAAAAAATTAAAAATTTTGAAAGAGATAATTTTGAAAAATATTATCATCTT GATGCAGTAAGAGTTGCTTTAGCTCAATTTAAAAACTACTTTAGTCTTTCTACCGCTGCCATCGAGCAAA ATAATTCGACATTTGAAAGCGAAGAGACACTGGCGAAAAAGACAGAGCTCATTAATAAACTGGTTGATAT CAGTGAAGATGGAACCCTTACGCCAAAAGAGCGTGTCGACCAAATATCTTTCCATGTTAAAAATCCTAAT TTTGAAAGAATCATCATGGATTACAAACAGGAAAGCTACTTTAGCTTTACCTATTTAAAACAATGCATCT TATCCTTATTGGAAGCGCTTTGCCTGTACACTCCGGAGAGAAGAAAACTATTTAATAATTTGGAAAGCTC TGTAAAAACCCAGCCTAAAATCAATGAACTGACCAAACGATTTGGATTATTTGCTGGCAATGAGTCAGCT ATCTCTACTGAATCCAGGGCAATTACCCCAGTTTCTTCTGTTGAAAATAATGGAACAATTGAATTAAACC AATTAGCGCCATCAACATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |