SecReT4
T4SS ID42
StrainLegionella pneumophila str. Corby
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_009494
Location531033..567456; 657116..657742; 3197889..3216591
NameDot/Icm
Functioneffector translocation
ClassificationType IVB; Type I
sequence This T4SS has been mentioned in a genome sequencing report.
structure Information of structure: structureGDP-bound Rab1a S25N mutant in complex with LidA, Rab1a in complex with LidA

T4SS components
ComponentDotADotBDotCDotDIcmBIcmCIcmDIcmEIcmF
Number111112111
ComponentIcmGIcmHIcmJIcmKIcmLIcmMIcmNIcmOIcmP
Number111111111
ComponentIcmQIcmRIcmSIcmTIcmVIcmWIcmXLvgA
Number11111111

The information of T4SS components from NC_009494
Region 1: 531033..567456
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LPC_2905526690..528690 [+], 2001148360945hypothetical protein 
2LPC_2904529509..530285 [-], 777148360944hypothetical protein 
3LPC_2903530651..530863 [+], 213148360943hypothetical protein 
4LPC_2902 (icmT)531033..531293 [+], 261148360942hypothetical protein  IcmT
5LPC_2901 (icmS)531294..531638 [+], 345148360941hypothetical protein  IcmSaccesspry protein
6LPC_2900 (icmR)531738..532100 [+], 363148360940hypothetical protein  IcmR
7LPC_2899 (icmQ)532191..532766 [+], 576148360939hypothetical protein  IcmQ
8LPC_2898 (icmP)532953..534083 [+], 1131148360938hypothetical protein  IcmP
9LPC_2897 (icmO)534080..536431 [+], 2352148360937hypothetical protein  IcmO
10LPC_2896 (lphA)536835..537404 [+], 570148360936hypothetical protein  IcmN
11LPC_2895 (icmM)537416..537700 [+], 285148360935hypothetical protein  IcmM
12LPC_2894 (icmL)537716..538354 [+], 639148360934hypothetical protein  IcmL
13LPC_2893 (icmK)538357..539439 [+], 1083148360933hypothetical protein  IcmK
14LPC_2892 (icmE)539444..542590 [+], 3147148360932hypothetical protein  IcmE
15LPC_2891 (icmG)542608..543414 [+], 807148360931hypothetical protein  IcmG
16LPC_2890543422..543763 [+], 342148360930hypothetical protein  IcmC
17LPC_2889 (icmD)544034..544432 [+], 399148360929hypothetical protein  IcmD
18LPC_2888 (icmJ)544632..545258 [+], 627148360928hypothetical protein  IcmJ
19LPC_2887 (icmB)545294..548323 [+], 3030148360927hypothetical protein  IcmB
20LPC_2886 (tphA)548469..549725 [-], 1257148360926proline/betaine transport protein like protein 
21LPC_2885 (icmF)549728..552649 [-], 2922148360925hypothetical protein  IcmF
22LPC_2884 (icmH)552649..553434 [-], 786148360924hypothetical protein  IcmH
23LPC_2883 (purH)553719..555308 [-], 1590148360923bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 
24LPC_2882 (prmA)555335..556204 [-], 870148360922ribosomal protein L11 methyltransferase 
25LPC_2881 (accC)556206..557549 [-], 1344148360921acetyl CoA carboxylase biotin carboxylase subunit 
26LPC_2880 (accB)557562..558044 [-], 483148360920acetyl-CoA carboxylase biotin carboxyl carrier protein 
27LPC_2879 (aroQ)558057..558494 [-], 4381483609193-dehydroquinate dehydratase 
28LPC_2878 (dcoA)558696..560486 [+], 1791148360918pyruvate carboxylase subunit B 
29LPC_2877 (proA)561052..562683 [+], 1632148360917zinc metalloprotease 
30LPC_2876562685..563533 [-], 849148360916alpha/beta hydrolase superfamily transporter protein 
31LPC_2875564002..564757 [+], 756148360915endonuclease/exonuclease/phosphatase family transporter protein 
32LPC_2874 (alf1)564936..565946 [-], 1011148360914fructose bisphosphate aldolase 
33LPC_2873 (poxF)566096..566788 [-], 693148360913phenol hydroxylase 
34LPC_2872 (dotV)566914..567456 [+], 543148360912hypothetical protein  IcmC
35LPC_2871567658..567942 [-], 285148360911hypothetical protein 
36LPC_2870 (pssA)568172..568909 [+], 738148360910CDP-diacylglycerol--serine O-phosphatidyltransferase 
37LPC_2869 (ptsH)569151..569420 [-], 270148360909sugar transport PTS system phosphocarrier HPr protein 
38LPC_2868569611..569910 [-], 300148360908sigma-54 modulation protein 
39LPC_2867 (rpoN)569937..571331 [-], 1395148360907RNA polymerase factor sigma-54 
40LPC_2866 (rpmG)571543..571707 [-], 16514836090650S ribosomal protein L33 
41LPC_2865 (rpmB)571722..571958 [-], 23714836090550S ribosomal protein L28 
42LPC_2864572056..572217 [+], 162148360904hypothetical protein 
 
Region 2: 657116..657742
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LPC_2784652210..652533 [-], 324148360824hypothetical protein 
2LPC_2782654017..655219 [+], 1203148360823proline/betaine transporter 
3LPC_2781655222..655566 [+], 345148360822hypothetical protein 
4LPC_2780655647..655844 [+], 198148360821hypothetical protein 
5LPC_2779655907..656674 [-], 768148360820hypothetical protein 
6LPC_2777 (lvgA)657116..657742 [+], 627148360819hypothetical protein  LvgAaccesspry protein
7LPC_2776657772..658149 [-], 378148360818hypothetical protein 
8LPC_2775658299..659438 [-], 1140148360817signal transduction protein 
9LPC_2774 (sdhC)659759..660133 [+], 375148360816succinate dehydrogenase cytochrome b556 subunit C 
10LPC_2773 (sdhD)660127..660474 [+], 348148360815succinate dehydrogenase hydrophobic membrane anchor protein subunit D 
11LPC_2772 (sdhA)660476..662245 [+], 1770148360814succinate dehydrogenase flavoprotein subunit A 
 
Region 3: 3197889..3216591
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LPC_0468 (ftsY)3193519..3194586 [-], 1068148358595cell division membrane protein FtsY 
2LPC_04673194649..3195974 [+], 1326148358594zinc protease 
3LPC_04653195971..3197272 [+], 1302148358593zinc protease 
4LPC_04643197389..3197814 [+], 426148358592N6-adenine specific methylase 
5LPC_0463 (dotD)3197889..3198380 [+], 492148358591lipoprotein DotD  DotD
6LPC_0462 (dotC)3198361..3199272 [+], 912148358590organelle trafficking lipoprotein defect DotC  DotC
7LPC_0461 (dotB)3199296..3200405 [+], 1110148358589organelle trafficking lipoprotein defect DotB  DotB
8LPC_04603200491..3202218 [+], 17281483585885'-nucleotidase 
9LPC_04593202260..3203057 [-], 798148358587hypothetical protein 
10LPC_04583203087..3204031 [-], 945148358586D-isomer specific 2-hydroxyacid dehydrogenase 
11LPC_0457 (murE3)3204268..3205290 [+], 1023148358585UDP-N-acetylmuramyl tripeptide synthase 
12LPC_04563205452..3205568 [+], 117148358584hypothetical protein 
13LPC_04553205565..3206452 [+], 8881483585834-hydroxy-2-oxovalerate aldolase 
14LPC_04543206591..3207298 [+], 708148358582hypothetical protein 
15LPC_0453 (dlpA)3207285..3209129 [+], 1845148358581DlpA protein 
16LPC_04523209132..3209992 [+], 861148358580hypothetical protein 
17LPC_0451 (sbpA)3210254..3210970 [-], 717148358579dienelactone hydrolase family transporter protein 
18LPC_0450 (dotA)3211100..3214162 [-], 3063148358578organelle trafficking lipoprotein defect DotA  DotA
19LPC_0449 (icmV)3214159..3214614 [-], 456148358577intracellular multiplication protein IcmV  IcmV
20LPC_0448 (icmW)3214727..3215182 [+], 456148358576intracellular multiplication protein IcmW  IcmWaccesspry protein
21LPC_0447 (icmX)3215182..3216591 [+], 1410148358575intracellular multiplication protein IcmX  IcmX
22LPC_0446 (lphB)3216592..3218235 [-], 1644148358574hypothetical protein 
23LPC_04453218590..3221133 [+], 2544148358573cation transporting ATPase PacS 
 
accesspry protein This T4SS contains information of accessory protein.
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes

Effectors
RavA, CegC1, LPC_0022, RavB, AnkQ/legA10, LPC_0042, LPC_0047, LPC_0048, Ceg2, Lem1, Ceg4, VipF, CegC2, LPC_0151, SdhB, RavD, RavC, LPC_0253, LPC_0265, RavE, RavG, Ceg7, SidE/laiD, Ceg8, Ceg9, LPC_0334, LPC_0337, SdbA, LegG2, Ceg10, Lem2, LPC_0373, LPC_0385, LPC_0386, LegN, WipA, LegD1, LPC_0444, MavV, LPC_0503, LPC_0513, Lem28, Ceg33, LegS1, SidF, MavM, Ceg19, LPC_0582, LPC_0601, CegC3, Lem7, LPC_0610, LPC_0611, RavP, RavQ, LPC_0621, RavR, LPC_0637, RavS, VpdB, LPC_0698, LegT, VpdC, LPC_0868, LegK1, LPC_0899, Lgt3/legc5, RavX, Lem10, RavY, LPC_1002, LegC6, Lem11, LegL2, Ceg23, Lem23, LPC_1068, SidB, LPC_1084, LegL3, LPC_1091, LPC_1096, LPC_1097, LPC_1101, RavZ, LPC_1115, LPC_1116, MavA, LPC_1120, LPC_1123, PpeA/legC3, PpeB, LPC_1146, AnkI/legAS4, LPC_1191, LPC_1192, LPC_1217, RvfA, MarB, LPC_1246, Ceg25, Lem14, YlfB/legC2, LPC_1336, LegLC8, LPC_1361, LPC_1378, Lem15, Lem17, RalF, LegC4, LirA, LirB, PieA/lirC, PieC/lirE, PieD/lirF, PieE, PieF, PieG/legG1, SetA, LPC_1469, LPC_1536, LegK2, AnkB/legAU13/ceg27, MavC, LPC_1597, LPC_1598, SdeC, SdeC, SidJ, SdeB, LaiA/SdeA, LPC_1621, Lem19, LegS2, CegC4, CegC4, WipC, LegA2, Lem20, LpnE, LPC_1691, Lem21, LPC_1740, YlfA/legC7, AnkH/legA3, ankW, Ceg28, AnkK/legA5, LPC_1794, Lem22, MavE, MavF, LPC_1828, LegK3, LPC_1908, LPC_1911, LPC_1919, LPC_1927, LPC_1929, LPC_1930, Lem27, LnaB, MavL, SidC, SdcA, SdeD, SdjA, LPC_1966, SidI/ceg32, MavJ, LepB, SdbB, LPC_2015, AnkD/legA15, AnkF/legA14/ceg31, MavI, LPC_2033, LPC_2042, Ceg30, MavH, MavG, Lem25, LPC_2056, LegA1, Lem24, VpdA, Ceg29, LPC_2069, Lem23, LegL6, SdbC, LPC_2108, LseA, lpc_2128, lpc_2130, RavN, Lem5, RavM, RavL, LPC_2149, Lem4, RavK, SidK, LPC_2320, LPC_2324, LegL1, RavJ, LidA, RavI, Ceg18, RavH, LPC_2577, AnkN/ankX legA8, WipB, LPC_2660, SidA, LPC_2826, LegD2, AnkC/legA12, Ceg15, Ceg14, AnkJ/legA11, LegY, LPC_2939, AnkG/ankZ/legA7, LegA7/ceg11, VipA, SdhA, LPC_2968, LPC_2979, LPC_2980, LepA, Lem29, MavN, Ceg34, LPC_3115, LPC_3116, LPC_3128, LPC_3160, LPC_3165, LPC_3170, LPC_3171, LPC_3174, LPC_3214, LPC_3243, LPC_3248, LPC_3290, LegP, LPC_3316, Lem3

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1LPC_0009 11607..12866 [-], 1260148358148hypothetical protein  RavA
2LPC_0013 15327..16904 [-], 1578148358152hypothetical protein  CegC1
3LPC_0022 27124..27603 [+], 480148358161hypothetical protein  LPC_0022
4LPC_0031 38086..38976 [-], 891148358170hypothetical protein  RavB
5LPC_0039 44846..46363 [-], 1518148358178hypothetical protein  AnkQ/legA10
6LPC_0042 48359..50545 [+], 2187148358181hypothetical protein  LPC_0042
7LPC_0047 53050..53262 [-], 213148358186hypothetical protein  LPC_0047
8LPC_0048 53472..53870 [+], 399148358187hypothetical protein  LPC_0048
9LPC_0068 67713..68699 [+], 987148358207hypothetical protein  Ceg2
10LPC_0109 107976..111950 [+], 3975148358247hypothetical protein  Lem1
11LPC_0115 118420..119613 [+], 1194148358253hypothetical protein  Ceg4
12LPC_0122 126858..127718 [-], 861148358260N-terminal GNAT family transporter acetyltransferase  VipF
13LPC_0146 152018..155329 [+], 3312148358284ninein  CegC2
14LPC_0151 160195..162663 [+], 2469148358289hypothetical protein  LPC_0151
15LPC_0156 (sdhB)166083..171680 [-], 5598148358294Dot/Icm system substrate protein SdhB  SdhB
16LPC_0242 254047..255024 [+], 978148358378hypothetical protein  RavD
17LPC_0251 261448..262203 [-], 756148358387putative ABC transport system permeaseexperimental  RavC
18LPC_0253 262869..263567 [+], 699148358389hypothetical protein  LPC_0253
19LPC_0265 274273..275265 [+], 993148358400hypothetical protein  LPC_0265
20LPC_0272 284799..285791 [-], 993148358407hypothetical protein  RavE
21LPC_0285 300326..300913 [+], 588148358419hypothetical protein  RavG
22LPC_0303 316987..318009 [+], 1023148358437hypothetical protein  Ceg7
23LPC_0309 (sidE)327100..331590 [-], 4491148358443Dot/Icm system substrate protein SidE  SidE/laiD
24LPC_0316 (recN)338543..339310 [+], 768148358450DNA repair protein  Ceg8
25LPC_0323 347742..348314 [+], 573148358457hypothetical protein  Ceg9
26LPC_0334 357994..358986 [+], 993148358468multidrug resistance secretion protein  LPC_0334
27LPC_0337 363157..363477 [+], 321148358471hypothetical protein  LPC_0337
28LPC_0351 377462..378172 [+], 711148358485hypothetical protein  SdbA
29LPC_0353 380892..382445 [+], 1554148358487hypothetical protein  LegG2
30LPC_0361 392171..393295 [-], 1125148358495hypothetical protein  Ceg10
31LPC_0362 393552..394214 [+], 663148358496hypothetical protein  Lem2
32LPC_0373 404860..405552 [+], 693148358507hypothetical protein  LPC_0373
33LPC_0385 3273556..3275523 [-], 1968148358515hypothetical protein  LPC_0385
34LPC_0386 3272226..3273395 [-], 1170148358516hypothetical protein  LPC_0386
35LPC_0413 3249418..3250449 [+], 1032148358542hypothetical protein  LegN
36LPC_0415 3246445..3248007 [-], 1563148358544hypothetical protein  WipA
37LPC_0442 3222910..3223740 [-], 831148358570phytanoyl-CoA dioxygenase PhyH  LegD1
38LPC_0444 3221384..3221914 [+], 531148358572hypothetical protein  LPC_0444
39LPC_0502 3156837..3158219 [-], 1383148358627hypothetical protein  MavV
40LPC_0503 3155273..3156484 [-], 1212148358628hypothetical protein  LPC_0503
41LPC_0513 3146193..3146945 [-], 753148358637hypothetical protein  LPC_0513
42LPC_0539 3113885..3115126 [+], 1242148358663hypothetical protein  Lem28
43LPC_0551 3101336..3101839 [-], 504148358675hypothetical proteinexperimental  Ceg33
44LPC_0557 3096580..3097737 [-], 1158148358680acid sphingomyelinase-like phosphodiesteraseexperimental  LegS1
45LPC_0561 (sidF)3090000..3092738 [+], 2739148358684Dot/Icm system substrate protein  SidF
46LPC_0570 3082541..3083266 [-], 726148358693hypothetical protein  MavM
47LPC_0578 1354408..1355142 [+], 735148358700hypothetical protein  Ceg19
48LPC_0582 1358457..1359047 [-], 591148358704hypothetical protein  LPC_0582
49LPC_0601 1375184..1376137 [-], 954148358722hypothetical protein  LPC_0601
50LPC_0607 1381566..1382039 [-], 474148358728hypothetical protein  CegC3
51LPC_0608 1382332..1384641 [+], 2310148358729hypothetical protein  Lem7
52LPC_0610 1386313..1386816 [+], 504148358731hypothetical protein  LPC_0610
53LPC_0611 1387134..1388618 [+], 1485148358732hypothetical protein  LPC_0611
54LPC_0615 1391290..1392114 [-], 825148358736hypothetical protein  RavP
55LPC_0617 1394073..1395155 [+], 1083148358738hypothetical protein  RavQ
56LPC_0621 1399649..1400371 [+], 723148358742hypothetical protein  LPC_0621
57LPC_0631 1409730..1411718 [-], 1989148358752hypothetical protein  RavR
58LPC_0637 1417618..1418037 [+], 420148358758hypothetical protein  LPC_0637
59LPC_0650 1431292..1433151 [+], 1860148358770hypothetical protein  RavS
60LPC_0696 1478522..1480261 [+], 1740148358814hypothetical protein  VpdB
61LPC_0698 1480914..1481978 [+], 1065148358815hypothetical protein  LPC_0698
62LPC_0743 1532555..1534951 [-], 2397148358860hypothetical protein  LegT
63LPC_0842 1640575..1643226 [+], 2652148358957hypothetical protein  VpdC
64LPC_0868 1666759..1667277 [+], 519148358983hypothetical protein  LPC_0868
65LPC_0898 (lok)1700482..1702071 [+], 1590148359013serine/threonine-protein kinase  LegK1
66LPC_0899 1702125..1702874 [-], 750148359014hypothetical protein  LPC_0899
67LPC_0903 1705033..1707330 [+], 2298148359018hypothetical protein  Lgt3/legc5
68LPC_0905 1710381..1711406 [+], 1026148359019hypothetical protein  RavX
69LPC_0915 1717681..1719489 [+], 1809148359029hypothetical protein  Lem10
70LPC_0972 1781359..1782135 [-], 777148359085hypothetical protein  RavY
71LPC_1002 1810752..1811165 [-], 414148359114hypothetical protein  LPC_1002
72LPC_1013 1823001..1825019 [-], 2019148359125hypothetical protein  LegC6
73LPC_1025 1832915..1833976 [-], 1062148359135hypothetical protein  Lem11
74LPC_1028 1834360..1835646 [-], 1287148359136hypothetical protein  LegL2
75LPC_1048 1857243..1858562 [-], 1320148359156hypothetical protein  Ceg23
76LPC_1052 1861942..1862337 [-], 396148359160hypothetical protein  Lem23
77LPC_1068 1878990..1880249 [-], 1260148359174hypothetical protein  LPC_1068
78LPC_1071 (sidB)1883152..1884405 [-], 1254148359177Dot/Icm system substrate protein LidA  SidB
79LPC_1084 1899146..1900261 [-], 1116148359190hypothetical protein  LPC_1084
80LPC_1090 1906673..1908154 [+], 1482148359196hypothetical protein  LegL3
81LPC_1091 1908248..1909366 [-], 1119148359197hypothetical protein  LPC_1091
82LPC_1096 1919383..1920744 [-], 1362148359202hypothetical protein  LPC_1096
83LPC_1097 1920947..1922314 [-], 1368148359203hypothetical protein  LPC_1097
84LPC_1101 1926992..1927882 [+], 891148359207hypothetical protein  LPC_1101
85LPC_1114 1943447..1944955 [+], 1509148359220hypothetical protein  RavZ
86LPC_1115 1945259..1946656 [+], 1398148359221hypothetical protein  LPC_1115
87LPC_1116 1946667..1947536 [-], 870148359222hypothetical protein  LPC_1116
88LPC_1118 1948123..1949325 [-], 1203148359224hypothetical protein  MavA
89LPC_1120 1950790..1951416 [+], 62714835922623.7 kDa protein  LPC_1120
90LPC_1123 1956129..1957439 [+], 1311148359229hypothetical protein  LPC_1123
91LPC_1130 (ktn1)1965405..1967081 [+], 1677148359236kinectin 1  PpeA/legC3
92LPC_1131 1967217..1968857 [+], 1641148359237hypothetical protein  PpeB
93LPC_1146 1983047..1983505 [+], 459148359251hypothetical protein  LPC_1146
94LPC_1152 1989183..1990820 [-], 1638148359257hypothetical protein  AnkI/legAS4
95LPC_1191 2033794..2035107 [-], 1314148359295hypothetical protein  LPC_1191
96LPC_1192 2035120..2035728 [-], 609148359296hypothetical protein  LPC_1192
97LPC_1217 2065155..2065640 [+], 486148359320hypothetical protein  LPC_1217
98LPC_1239 2084889..2086130 [+], 1242148359342hypothetical protein  RvfA
99LPC_1241 2086315..2087511 [-], 1197148359343hypothetical protein  MarB
100LPC_1246 2092430..2093365 [-], 936148359348hypothetical protein  LPC_1246
101LPC_1280 2137011..2138429 [+], 1419148359382coiled coil domain-containing protein  Ceg25
102LPC_1296 2153391..2154053 [-], 663148359398hypothetical protein  Lem14
103LPC_1331 2188330..2189547 [+], 1218148359424microtubule binding protein  YlfB/legC2
104LPC_1336 2192802..2194133 [-], 1332148359429hypothetical protein  LPC_1336
105LPC_1338 2195391..2197052 [-], 1662148359431hypothetical protein  LegLC8
106LPC_1361 2216802..2218607 [-], 1806148359454hypothetical protein  LPC_1361
107LPC_1378 2236946..2239738 [+], 2793148359471hypothetical protein  LPC_1378
108LPC_1406 2265578..2266192 [-], 615148359496hypothetical protein  Lem15
109LPC_1422 2283783..2285117 [-], 1335148359512hypothetical protein  Lem17
110LPC_1423 (ralF)2285351..2286547 [+], 1197148359513Dot/Icm system substrate RalF protein  RalF
111LPC_1426 2288929..2291163 [-], 2235148359516hypothetical protein  LegC4
112LPC_1437 2304284..2305057 [+], 774148359527hypothetical protein  LirA
113LPC_1440 2307971..2308537 [+], 567148359529peptidyl-prolyl cis-trans isomerase  LirB
114LPC_1441 2308618..2308965 [-], 348148359530hypothetical protein  PieA/lirC
115LPC_1443 2311071..2313098 [-], 2028148359532hypothetical protein  PieC/lirE
116LPC_1446 2317024..2318589 [-], 1566148359534hypothetical protein  PieD/lirF
117LPC_1452 2321503..2323296 [-], 1794148359540hypothetical protein  PieE
118LPC_1459 2328102..2328482 [-], 381148359547hypothetical protein  PieF
119LPC_1462 2331156..2332598 [+], 1443148359550UVB-resistance protein UVR8  PieG/legG1
120LPC_1464 2333441..2335336 [-], 1896148359552teichoic acid biosynthesis protein  SetA
121LPC_1469 2340915..2343725 [-], 2811148359557hypothetical protein  LPC_1469
122LPC_1536 2408337..2409395 [-], 1059148359624hypothetical protein  LPC_1536
123LPC_1586 2467503..2469131 [-], 1629148359667calmodulin-dependent protein kinase  LegK2
124LPC_1593 (pof1)2473972..2474439 [+], 468148359674F-box protein  AnkB/legAU13/ceg27
125LPC_1596 2477743..2479191 [+], 1449148359677hypothetical protein  MavC
126LPC_1597 2479369..2480547 [+], 1179148359678hypothetical protein  LPC_1597
127LPC_1598 2480635..2480994 [+], 360148359679hypothetical protein  LPC_1598
128LPC_1602 (sdeC)2484948..2489555 [+], 4608148359683Dot/Icm system substrate protein SdeC  SdeC
129LPC_1603 2489769..2490890 [+], 1122148359684Sid related protein-like protein  SdeC
130LPC_1604 2490944..2493571 [+], 2628148359685hypothetical protein  SidJ
131LPC_1605 (sdeB)2493848..2499613 [+], 5766148359686Dot/Icm system substrate protein SdeB  SdeB
132LPC_1618 2527727..2532367 [+], 4641148359697hypothetical protein  LaiA/SdeA
133LPC_1621 2534971..2536338 [-], 1368148359700hypothetical protein  LPC_1621
134LPC_1626 2541826..2543076 [+], 1251148359705hypothetical protein  Lem19
135LPC_1635 2549721..2551538 [-], 1818148359713sphingosine-1-phosphate lyase I  LegS2
136LPC_1663 2599156..2599737 [-], 582148359739hypothetical protein  CegC4
137LPC_1664 2599955..2600491 [-], 537148359740hypothetical protein  CegC4
138LPC_1671 2606915..2608015 [+], 1101148359747hypothetical protein  WipC
139LPC_1680 2616505..2618100 [-], 1596148359756hypothetical protein  LegA2
140LPC_1681 2618121..2619893 [-], 1773148359757purine NTPase  Lem20
141LPC_1689 2626526..2627653 [-], 1128148359764TPR repeat-containing protein  LpnE
142LPC_1691 2628934..2630169 [-], 1236148359766hypothetical protein  LPC_1691
143LPC_1717 2665029..2667263 [-], 2235148359792hypothetical protein  Lem21
144LPC_1740 2690280..2690930 [+], 651148359815hypothetical protein  LPC_1740
145LPC_1763 2710387..2711664 [-], 1278148359835inclusion membrane protein A  YlfA/legC7
146LPC_1765 2715046..2716449 [-], 1404148359837ankyrin repeat domain-containing proteinexperimental  AnkH/legA3, ankW
147LPC_1776 2724477..2727920 [-], 3444148359848interaptin  Ceg28
148LPC_1789 2737537..2739462 [-], 1926148359861cardiac ankyrin repeat-containing proteinexperimental  AnkK/legA5
149LPC_1794 2745398..2746276 [+], 879148359866hypothetical protein  LPC_1794
150LPC_1795 2746539..2746922 [+], 384148359867hypothetical protein  Lem22
151LPC_1812 2760747..2761262 [+], 516148359884hypothetical protein  MavE
152LPC_1820 2769179..2770030 [+], 852148359892hypothetical proteinexperimental  MavF
153LPC_1828 (lporfX)2777330..2777773 [+], 444148359900hypothetical protein  LPC_1828
154LPC_1906 3064303..3065691 [+], 1389148359976putative protein kinase  LegK3
155LPC_1908 3062878..3063720 [-], 843148359978hypothetical protein  LPC_1908
156LPC_1911 3058451..3060118 [-], 1668148359981hypothetical protein  LPC_1911
157LPC_1919 3051992..3053389 [-], 1398148359989hypothetical protein  LPC_1919
158LPC_1927 3046032..3046859 [-], 828148359997hypothetical protein  LPC_1927
159LPC_1929 3044914..3045282 [-], 369148359999hypothetical protein  LPC_1929
160LPC_1930 3042916..3044262 [-], 1347148360000hypothetical protein  LPC_1930
161LPC_1942 3032887..3034581 [-], 1695148360011hypothetical protein  Lem27
162LPC_1944 3029220..3030842 [-], 1623148360013hypothetical protein  LnaB
163LPC_1946 3027515..3028756 [-], 1242148360015hypothetical protein  MavL
164LPC_1959 (sidC)3012349..3015078 [+], 2730148360028Dot/Icm system substrate protein SidC  SidC
165LPC_1960 3009469..3012186 [+], 2718148360029hypothetical protein  SdcA
166LPC_1961 (sdeD)3008018..3009166 [-], 1149148360030Dot/Icm system substrate protein SdeD  SdeD
167LPC_1962 3007464..3007946 [-], 483148360031hypothetical protein  SdjA
168LPC_1966 3001844..3002716 [+], 873148360035hypothetical protein  LPC_1966
169LPC_1967 2998996..3001824 [+], 2829148360036hypothetical protein  SidI/ceg32
170LPC_1975 2993572..2994465 [+], 894148360044hypothetical protein  MavJ
171LPC_1987 (lepB)2980905..2984789 [+], 3885148360056effector protein B  LepB
172LPC_1996 (sdbB)2972319..2973665 [+], 1347148360065Dot/Icm system substrate protein SdbB  SdbB
173LPC_2015 2954917..2955534 [+], 618148360084hypothetical protein  LPC_2015
174LPC_2020 2950419..2951840 [+], 1422148360089hypothetical protein  AnkD/legA15
175LPC_2026 2944691..2947456 [-], 2766148360095hypothetical protein  AnkF/legA14/ceg31
176LPC_2032 2940199..2940750 [-], 552148360101hypothetical protein  MavI
177LPC_2033 2939421..2939954 [-], 534148360102hypothetical protein  LPC_2033
178LPC_2042 2932298..2932783 [+], 486148360111hypothetical protein  LPC_2042
179LPC_2043 2930238..2932022 [+], 1785148360112hypothetical protein  Ceg30
180LPC_2051 2921998..2922798 [-], 801148360120hypothetical protein  MavH
181LPC_2053 2919584..2920927 [-], 1344148360122hypothetical protein  MavG
182LPC_2055 2915211..2917475 [-], 2265148360124hypothetical protein  Lem25
183LPC_2056 2914562..2915113 [+], 552148360125hypothetical protein  LPC_2056
184LPC_2057 2913374..2914357 [+], 984148360126ankyrin repeat family transporter protein  LegA1
185LPC_2064 2908869..2909696 [-], 828148360133hypothetical protein  Lem24
186LPC_2065 2906769..2908766 [+], 1998148360134patatin-like phospholipase  VpdA
187LPC_2067 2903774..2904592 [+], 819148360136hypothetical protein  Ceg29
188LPC_2069 2902261..2902566 [-], 306148360138hypothetical protein  LPC_2069
189LPC_2070 (lidE)2900982..2902079 [+], 1098148360139hypothetical protein  Lem23
190LPC_2085 2887113..2887997 [+], 885148360154hypothetical protein  LegL6
191LPC_2086 2885548..2886852 [-], 1305148360155hypothetical protein  SdbC
192LPC_2108 2857154..2858608 [+], 1455148360177hypothetical protein  LPC_2108
193LPC_2110 2855771..2856064 [-], 294148360179hypothetical proteinexperimental  LseAinteraction
194LPC_2128 2838762..2840456 [-], 1695148360196hypothetical proteinexperimental  lpc_2128
195LPC_2130 2836309..2837241 [-], 933148360198hypothetical proteinexperimental  lpc_2130
196LPC_2141 1340775..1341413 [-], 639148360209hypothetical protein  RavN
197LPC_2142 1339986..1340681 [+], 696148360210hypothetical protein  Lem5
198LPC_2145 1334776..1336836 [-], 2061148360212hypothetical protein  RavM
199LPC_2146 1333654..1334535 [-], 882148360213putative lipase  RavL
200LPC_2149 1329962..1331224 [-], 1263148360216hypothetical protein  LPC_2149
201LPC_2154 1324982..1325383 [+], 402148360221hypothetical protein  Lem4
202LPC_2318 1170961..1171701 [+], 741148360379hypothetical protein  RavK
203LPC_2319 1168799..1170493 [-], 1695148360380hypothetical protein  SidK
204LPC_2320 1167839..1168390 [-], 552148360381hypothetical protein  LPC_2320
205LPC_2324 1161798..1163039 [-], 1242148360385hypothetical protein  LPC_2324
206LPC_2344 1132619..1133506 [-], 888148360405Gala protein  LegL1
207LPC_2345 1131282..1132457 [-], 1176148360406hypothetical protein  RavJ
208LPC_2349 (lidA)1123824..1126031 [-], 2208148360410Dot/Icm system substrate protein LidA  LidA
209LPC_2365 1107917..1108924 [-], 1008148360426hypothetical protein  RavI
210LPC_2395 1079658..1080362 [-], 705148360456hypothetical protein  Ceg18
211LPC_2559 909203..910627 [+], 1425148360613hypothetical protein  RavH
212LPC_2577 890765..891760 [+], 996148360631hypothetical protein  LPC_2577
213LPC_2599 864623..867460 [+], 2838148360653hypothetical protein  AnkN/ankX legA8
214LPC_2651 777751..779325 [+], 1575148360704hypothetical protein  WipB
215LPC_2660 767756..769093 [-], 1338148360712hypothetical protein  LPC_2660
216LPC_2673 (sidA)751289..752713 [-], 1425148360725Dot/Icm system substrate protein SidA  SidA
217LPC_2826 609848..610696 [-], 849148360866hypothetical protein  LPC_2826
218LPC_2829 606809..607741 [+], 933148360869hypothetical protein  LegD2
219LPC_2861 574118..575605 [+], 1488148360901hypothetical proteinexperimental  AnkC/legA12
220LPC_2904 529509..530285 [-], 777148360944hypothetical protein  Ceg15
221LPC_2905 526690..528690 [+], 2001148360945hypothetical protein  Ceg14
222LPC_2906 525619..526419 [-], 801148360946hypothetical protein  AnkJ/legA11
223LPC_2921 514320..515603 [-], 1284148360961glucoamylase  LegY
224LPC_2939 498432..498956 [+], 525148360979hypothetical protein  LPC_2939
225LPC_2941 495128..496636 [+], 1509148360981hypothetical protein  AnkG/ankZ/legA7
226LPC_2942 494190..494855 [-], 666148360982hypothetical protein  LegA7/ceg11
227LPC_2954 485924..486943 [-], 1020148360994hypothetical protein  VipA
228LPC_2967 (sdhA)468751..473040 [-], 4290148361007Dot/Icm system substrate protein SdhA  SdhA
229LPC_2968 468112..468711 [+], 600148361008hypothetical protein  LPC_2968
230LPC_2979 458580..461270 [-], 2691148361019hypothetical protein  LPC_2979
231LPC_2980 458089..458394 [-], 306148361020hypothetical protein  LPC_2980
232LPC_3079 (lepA)3320887..3324333 [+], 3447148361105interaptin LepA  LepA
233LPC_3090 3336183..3337496 [-], 1314148361116hypothetical protein  Lem29
234LPC_3101 3353361..3355343 [+], 1983148361127hypothetical proteinexperimental  MavN
235LPC_3113 3367667..3369385 [-], 1719148361139hypothetical protein  Ceg34
236LPC_3115 3370869..3372125 [+], 1257148361141hypothetical protein  LPC_3115
237LPC_3116 3372225..3373865 [-], 1641148361142hypothetical protein  LPC_3116
238LPC_3128 3386902..3388065 [-], 1164148361154hypothetical protein  LPC_3128
239LPC_3160 3420132..3421016 [-], 885148361186hypothetical protein  LPC_3160
240LPC_3165 3426544..3428277 [-], 1734148361191hypothetical protein  LPC_3165
241LPC_3170 3432694..3433431 [-], 738148361196hypothetical protein  LPC_3170
242LPC_3171 3433741..3434283 [-], 543148361197hypothetical protein  LPC_3171
243LPC_3174 3436778..3438691 [+], 1914148361200hypothetical protein  LPC_3174
244LPC_3214 3470741..3472228 [+], 1488148361240hypothetical protein  LPC_3214
245LPC_3243 3494841..3495569 [-], 72914836126916S ribosomal RNA methyltransferase RsmE  LPC_3243
246LPC_3248 3499298..3500566 [-], 1269148361274hypothetical protein  LPC_3248
247LPC_3290 3540771..3543386 [-], 2616148361315hypothetical protein  LPC_3290
248LPC_3315 3569720..3570520 [+], 801148361340metalloproteinase-like protein  LegP
249LPC_3316 3570517..3572355 [-], 1839148361341hypothetical protein  LPC_3316
250LPC_2598 867467..869125 [-], 1659295815283hypothetical protein  Lem3

interaction This effector contains information of interaction.

Download FASTA format files
Proteins        Genes
The information on structure of this T4ss

#NameImageResourceDetailReference
1GDP-bound Rab1a S25N mutant in complex with LidA3SFV PDB (3SFV)Crystal structure of the GDP-bound Rab1a S25N mutant in complex with the coiled-coil domain of LidA from Legionella pneumophila.(1) PubMed: 22416225
2Rab1a in complex with LidA 3TKL PDB (3TKL)Crystal structure of the GTP-bound Rab1a in complex with the coiled-coil domain of LidA from Legionella pneumophila.(2) PubMed: 22416225
(1) Cheng W et al. (2012). Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state.. PLoS Pathog. 8(3):e1002528. [PudMed:22416225] experimental
(2) Cheng W et al. (2012). Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state.. PLoS Pathog. 8(3):e1002528. [PudMed:22416225] experimental
The information on requirements for T4SS substrate-channel docking

Certain T4SS substrates require secretion chaperones for translocation. These chaperones often possess physical properties (small size of 15 kDa, acidic pI, and amphipathic helices) resembling those of chaperones associated with the type III secretion systems, a family of macromolecular translocation systems ancestrally related to bacterial flagella.

#Accessory protein(GI)motif(s)Substrate(s)FunctionReference
1IcmS (148360941)C-terminal fragment-The IcmS adaptors essential for translocation of different subsets of effectors through the Legionella Dot/Icm translocation apparatus.(1) PubMed: 28714967
2IcmS/IcmW (chaperones)CT Val-2 and Leu-3 required for translocationAnkBThe IcmSW chaperone complex is essential for translocation of AnkB.(2) PubMed: 18811729
3IcmS/IcmW (chaperones)C-terminal hydrophbic tail, CT20aasidGThe IcmSW complex interacts with a central region of the SidG protein. It resulted in a conformational change in the SidG protein as determined by differences in protease sensitivity in vitro. (3) PubMed: 18069892
4IcmS/IcmW (chaperones)C-terminal hydrophobic tail, CT100aa sufficientsidCIcmSW could enhance effector protein translocation by mediating a conformational change. (4) PubMed: 16714592
5IcmS/IcmW (chaperones)C-terminal hydrophobic tail. CT30aa sufficientlegS2LegS2 translocation depends on a functional IcmS IcmW complex.(5) PubMed: 19438520
6IcmW (148358576)C-terminal fragment-The IcmW adaptors essential for translocation of different subsets of effectors through the Legionella Dot/Icm translocation apparatus.(6) PubMed: 19946141
7LvgA (148360819)C-terminal fragment-The LvgA adaptors essential for translocation of different subsets of effectors through the Legionella Dot/Icm translocation apparatus.(7) PubMed: 28714967
Tips:
1.Substrate(s): For the conjugation systems, the listed proteins are relaxases that bind a cognate T4CP and are delivered to recipient cells. For the effector translocator systems, the listed proteins are effectors that play a role in the infection processes of the bacterial pathogen.
2.motif(s):The motifs listed are required for substrate translocation. In some cases, the protein or its C-terminal fragment (CT) is sufficient to mediate translocation to target cells, as shown by fusion to a reporter protein such as Cre recombinase or adenylate cyclase. Amino acids (aa) at positions listed relative to the C-terminal fragment (subscript) are required for translocation, as shown by mutational analysis. ND, not determined. Parentheses indicate that the interaction between a protein substrate and a cognate T4CP has been experimentally shown.
3.Accessory protein: Accessory factors required for T4SS channel docking or translocation. The proposed function in mediating substrate-T4SS channel docking is shown in parentheses.PubMed:19946141

(1) Kwak MJ et al. (2017). Architecture of the type IV coupling protein complex of Legionella pneumophila. Nat Microbiol. 2:17114. [PudMed:28714967] experimental
(2) Al-Khodor S; Price CT; Habyarimana F; Kalia A; Abu Kwaik Y (2008). A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa. Mol Microbiol. 70(4):908-23. [PudMed:18811729] experimental
(3) Cambronne ED; Roy CR (2007). The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocation. PLoS Pathog. 3(12):e188. [PudMed:18069892] experimental
(4) VanRheenen SM; Luo ZQ; O'Connor T; Isberg RR (2006). Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun. 74(6):3597-606. [PudMed:16714592] experimental
(5) Degtyar E; Zusman T; Ehrlich M; Segal G (2009). A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria. Cell Microbiol. 11(8):1219-35. [PudMed:19438520] experimental in_silico
(6) Alvarez-Martinez CE; Christie PJ (2009). Biological diversity of prokaryotic type IV secretion systems. Microbiol Mol Biol Rev. 73(4):775-808. [PudMed:19946141]
(7) Kwak MJ et al. (2017). Architecture of the type IV coupling protein complex of Legionella pneumophila. Nat Microbiol. 2:17114. [PudMed:28714967] experimental
The information on host-pathogen interaction.

#Name(Protein GI)Host site/SubstrateSourceFunctionReference
1LseA (148360179)Golgi membranesmurineLseA localized to membranes associated with the Golgi complex to interact with a subset of Qa-, Qb- and R-SNAREs in host cells.(1) PubMed: 25488819experimental
experimental This T4SE is mentioned in the literature.

(1) King et al. (2015). Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector. Cell Microbiol. 17(6):767-84. [PudMed:25488819] experimental in_silico
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(2) D'Auria G; Jimenez-Hernandez N; Peris-Bondia F; Moya A; Latorre A (2010). Legionella pneumophila pangenome reveals strain-specific virulence factors. BMC Genomics. 0.584027778. [PudMed:20236513]
 
in_silico This literature contains bioinformatics investigation

Genomics & Bioinformatics Group in MML, SJTU