| Effector Protein ID: 148360380 |
 T4SS name [ID] | Dot/Icm [42] |
| Gene symbol | - |
| Locus tag | LPC_2319 |
| Strain | Legionella pneumophila str. Corby |
| Replicon | chromosome [GenBank: NC_009494] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1168799..1170493 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | SidK |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidK interacts with VatA, a key component of the proton pump, leading to the inhibition of ATP hydrolysis and proton translocation. When delivered into macrophages, SidK inhibits vacuole acidification and bacterial killing. (Xu et al., 2010) |
| UniProt ID | A5IFU1 |
| KEGG ID | lpc:LPC_2319 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 564 a.a. [Download] |
| >gi|148360380|ref|YP_001251587.1| hypothetical protein LPC_2319 [Legionella pneumophila str. Corby] MGGLTSEQYHSQVVGKIGYIARCMQTIDPENNLKKIREDYQDVLIWAEKNYRFEEILEASKSGKCPNDLD ALSRRSLILQELLRLVSSISPFKMKLDLIESQYEKMKQHVNLWKSDYHVKLNQLNQLTDYLKNAAPTPKN HFLRAMTSALQMQIAQYGITEDNEGINQLFKLGLHLLAMANEKIDEQYHLFKRYVKDQPEESPFEGILPV EDQKILVKAMIDYAVPKLSLKVLQDKLSAVSSSDALTKTLLDSIDRIVEENEKLNALSKVKLGKFSLDIR EIEEIYSQALKISPQDALLYTAQQCDAKLLSMAFPDSQNYIVESISNKEAKAIAELIHSKEFLYQIIKTE VFKQVDPNEKIRLQAAIELYQLLGRTMDKQIHLFAKMNLEQINEYIQTKTKSILDKIPERVELLTFMGFE IPTFKGIETLMTDISHSQDNETLAIAQEFYTNIKNAKNQLLGDKLIEDITPQDVEKFFNQCSQYGSEAAE KLADNRPVLTKIADILTAIARWAISLIGFNTPPQFLAPTRTCVDQVSDEITKIKLKLEDTLGSLQKAQEE SLSL |
| - |
| Nucleotide Sequence: 1695 bp [Download] |
| >gi|295815281|ref|NC_009494.2|:c1170493-1168799 Legionella pneumophila str. Corby chromosome, complete genome ATGGGTGGCTTAACTAGCGAGCAATATCATAGTCAAGTAGTCGGCAAAATTGGATATATCGCCAGATGCA TGCAAACTATAGATCCTGAAAATAATTTGAAAAAGATAAGAGAAGATTACCAAGATGTATTGATATGGGC AGAGAAAAATTATCGTTTTGAAGAAATATTGGAAGCCAGCAAATCTGGAAAGTGCCCAAATGATCTGGAT GCATTAAGTCGACGATCGTTAATACTCCAAGAATTGCTACGGCTTGTTTCATCAATTAGTCCCTTTAAAA TGAAATTAGACCTGATTGAGTCTCAATATGAGAAAATGAAACAACATGTGAATTTATGGAAAAGTGATTA CCATGTAAAACTAAATCAATTGAATCAATTAACAGACTACCTCAAAAATGCAGCACCAACTCCTAAAAAT CATTTTCTAAGAGCAATGACCTCTGCATTGCAAATGCAGATAGCCCAATATGGGATTACAGAAGATAATG AGGGTATCAACCAGTTGTTTAAACTGGGATTGCATTTACTCGCAATGGCTAACGAAAAAATAGATGAACA ATATCATCTGTTTAAAAGGTATGTAAAAGATCAGCCTGAAGAATCTCCTTTTGAGGGCATTTTGCCTGTG GAAGACCAGAAAATTTTAGTCAAAGCTATGATAGATTATGCCGTGCCGAAACTTTCACTTAAGGTTTTAC AAGATAAATTATCAGCAGTATCCAGTTCTGATGCATTAACAAAAACATTACTTGATAGCATCGACAGAAT TGTTGAAGAAAACGAAAAATTAAATGCTTTAAGCAAAGTCAAATTAGGTAAATTTAGCCTGGATATCAGG GAAATTGAAGAGATATACTCTCAAGCTCTGAAAATATCGCCACAAGATGCTTTGCTATATACTGCTCAAC AATGTGATGCCAAATTATTAAGCATGGCATTTCCTGATTCCCAAAATTACATTGTTGAATCTATATCGAA CAAAGAGGCCAAGGCCATTGCAGAGCTAATCCATAGTAAAGAATTTCTTTATCAAATTATTAAAACAGAA GTTTTTAAACAAGTTGATCCTAATGAGAAAATTCGACTACAAGCCGCAATAGAATTGTATCAGCTTCTTG GGAGAACCATGGATAAACAGATCCATCTTTTTGCCAAGATGAATCTCGAACAAATTAATGAATATATTCA AACCAAAACCAAATCAATCCTGGATAAAATTCCTGAAAGAGTTGAGTTATTAACTTTTATGGGCTTTGAA ATTCCAACTTTCAAGGGAATTGAGACGCTTATGACCGACATCTCCCATTCTCAGGATAATGAAACTCTGG CGATAGCCCAAGAATTTTATACAAATATAAAAAATGCCAAGAACCAATTGTTGGGTGATAAACTGATTGA AGACATTACTCCACAGGATGTAGAGAAATTTTTTAATCAATGTAGTCAATACGGTTCAGAAGCAGCTGAA AAGTTAGCTGACAATCGCCCGGTACTGACAAAAATTGCTGATATTTTGACTGCCATTGCCCGTTGGGCGA TTAGTTTAATAGGTTTCAACACGCCACCGCAGTTTTTGGCTCCAACCAGAACATGTGTGGATCAGGTATC TGATGAAATCACTAAAATTAAACTCAAACTTGAAGATACTTTGGGAAGCTTGCAAAAAGCACAGGAAGAA AGCCTAAGTCTTTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |