| Effector Protein ID: 148359837 |
 T4SS name [ID] | Dot/Icm [42] |
| Gene symbol | - |
| Locus tag | LPC_1765 |
| Strain | Legionella pneumophila str. Corby |
| Replicon | chromosome [GenBank: NC_009494] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2715046..2716449 [-] |
| Product | ankyrin repeat domain-containing protein |
| Effector type | Protein |
| Descripton | AnkH/legA3, ankW |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkH is required for intracellular replication |
| UniProt ID | A5IE98 |
| KEGG ID | lpc:LPC_1765 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 2.7e-28, Aligned region: 19..93 Ank_2 [PF12796], Evalue: 2.7e-28, Aligned region: 36..125 Ank [PF00023], Evalue: 2.6e-17, Aligned region: 65..95 Ank_4 [PF13637], Evalue: 3.4e-14, Aligned region: 34..85 Ank_4 [PF13637], Evalue: 3.4e-14, Aligned region: 65..104 Ank_5 [PF13857], Evalue: 2.7e-12, Aligned region: 54..98 Ank_3 [PF13606], Evalue: 2.4e-11, Aligned region: 65..93 |
| Protein Sequence: 467 a.a. [Download] |
| >gi|148359837|ref|YP_001251044.1| ankyrin repeat domain-containing protein [Legionella pneumophila str. Corby] MSIANDIISHRMPDFDAYLRAGESLDDIDEYGFTPLIECAITRQIKIAEQLIARKVDINKPDVTGRTPLH WAVDNNDLDMTKLLLTYGADPNAYTRNGLCVLVYPVLRGQDAIKQLLYHHGAKLDFALDFINAKLIGHRF ELQGDVDIVNAKGEFIELDYEGFILEFTVAVVKDSLRRFISSYSTRHLRDYFPYIHNIMDAFTDAAELLQ YQHHPRLGEQHFKRIAALLKAPMLILPAASRGHALCFVRYHQWWAKIDRGENSLQEGSVNIYRITRPEAL TINFIHDFLYKKQNRRYYHQMINQQLGLLPFAQMPISSQISGNCSWANVQAVVPVAYSMQELTSVENFKP DVALSLYDEWVEWDKDRALDECIQRFYLASPERKASIAAILGGILFQACDHANKRHLERAEKILNILILD EYYYVLSSYLEEYCIKRLTRKGNNLLKILDDCGINPNIGVNPVATGL |
| - |
| Nucleotide Sequence: 1404 bp [Download] |
| >gi|295815281|ref|NC_009494.2|:c2716449-2715046 Legionella pneumophila str. Corby chromosome, complete genome ATGAGTATTGCAAACGATATTATCAGTCATAGAATGCCTGATTTTGATGCTTATCTGCGTGCAGGGGAAT CTTTGGATGATATCGATGAATATGGTTTTACTCCCCTCATAGAGTGTGCCATTACACGACAAATTAAAAT AGCAGAGCAGTTAATTGCTCGAAAAGTGGATATCAACAAGCCAGACGTCACAGGACGCACTCCATTACAT TGGGCAGTGGATAATAATGATTTGGATATGACCAAACTCTTATTAACCTACGGCGCTGATCCTAATGCCT ACACTCGTAATGGTCTTTGTGTGTTGGTTTATCCGGTTTTGCGTGGCCAAGATGCAATAAAGCAGTTGTT ATATCATCATGGTGCGAAGCTTGATTTTGCTCTTGATTTTATTAATGCAAAATTGATTGGTCATCGATTT GAATTGCAAGGTGATGTGGATATTGTCAATGCGAAAGGTGAATTCATCGAACTTGATTATGAAGGGTTTA TTTTGGAATTCACTGTTGCTGTTGTAAAAGACTCCTTGCGGAGATTTATCAGTAGTTATTCGACTCGGCA TTTAAGGGATTATTTTCCATATATTCATAATATTATGGATGCTTTTACTGATGCGGCAGAACTGTTGCAG TATCAACATCATCCCAGACTTGGCGAACAGCATTTCAAACGTATCGCTGCTTTGTTAAAAGCCCCTATGC TGATTCTTCCTGCGGCGAGTCGTGGCCATGCCTTATGCTTTGTCCGTTATCACCAGTGGTGGGCAAAAAT TGACAGGGGTGAAAACAGCTTACAAGAAGGAAGTGTTAATATTTACCGAATAACCAGGCCAGAGGCACTG ACAATCAATTTTATCCATGATTTTTTATATAAAAAACAAAACAGACGATATTATCATCAAATGATTAATC AACAATTGGGGCTGCTTCCTTTTGCTCAAATGCCAATTAGTTCTCAAATTAGTGGAAATTGTTCGTGGGC TAATGTGCAAGCCGTTGTACCAGTCGCGTATTCTATGCAAGAGCTGACCAGCGTAGAAAATTTTAAACCT GATGTGGCCTTATCACTGTATGATGAGTGGGTCGAGTGGGATAAAGACAGGGCTCTTGATGAATGCATAC AAAGATTTTATTTAGCCAGTCCTGAACGTAAGGCAAGTATTGCTGCAATCTTGGGAGGAATTTTGTTTCA GGCTTGTGATCACGCTAACAAGCGTCATCTGGAAAGAGCGGAGAAAATTCTTAATATTCTGATTTTAGAC GAATATTATTATGTTTTGAGCAGTTATCTGGAAGAATACTGTATTAAACGATTAACCCGTAAAGGAAATA ATTTATTGAAAATTCTGGATGATTGTGGGATTAATCCTAATATTGGCGTCAATCCTGTTGCGACAGGCCT ATAA |
| Reference |
(1) Gomez-Valero L et al. (2014). Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease. Genome Biol. 15(11):505. [PudMed:25370836] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |