| Effector Protein ID: 148359713 |
 T4SS name [ID] | Dot/Icm [42] |
| Gene symbol | - |
| Locus tag | LPC_1635 |
| Strain | Legionella pneumophila str. Corby |
| Replicon | chromosome [GenBank: NC_009494] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2549721..2551538 [-] |
| Product | sphingosine-1-phosphate lyase I |
| Effector type | Protein |
| Descripton | LegS2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegS2 is homologous to eukaryotic sphingosine-1-phosphate lyase and localizes to the mitochondria in host cells (Degtyar, et al. 2009) |
| UniProt ID | A5IDX4 |
| KEGG ID | lpc:LPC_1635 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pyridoxal_deC [PF00282], Evalue: 1.5e-15, Aligned region: 188..376 Aminotran_5 [PF00266], Evalue: 9.2e-10, Aligned region: 184..487 DegT_DnrJ_EryC1 [PF01041], Evalue: 3e-05, Aligned region: 210..328 |
| Protein Sequence: 605 a.a. [Download] |
| >gi|148359713|ref|YP_001250920.1| sphingosine-1-phosphate lyase I [Legionella pneumophila str. Corby] MFGFISDLLTAAVSSLDELLQDTPAHQIILGTAALYFLYNQYHNPSISRWYRSRNNASMKQRIIDSAYAL AKNLPGVNQIIEKELNKELSSTREKLRIQRSGMTLREEIPEEGLSPQDILSAFDVDVEKCHFDFLSVTND SPEREFLVGRGDGKDSGALYAIHPKELTELLKEVYGATALTNPLHDKWPRINAMQAEVIRWCQNLFHGSK EGYGLLTHGGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVDKKTGAVNP NVMSSYITRNTAVMVGSAPSFMNGIHDPVSELGQLAKKKNVPFHVDACLGGFLTAFLDTSSEPMDFRVPG VTSISADLHKYGCCPKGTSVCLFSEDSPALSVYAALNWSGGLYATPGILDGSTSGARVAEVYATLSYYGK NKYQEIAKSIIRLRNAIQKELTTLVEEGAGLTSEDIYVYGNPQWSILGFRSNTCNAHFIADELEKRGWKL NLLQNPDGFHLCLTHVHTVVKGFETQFINDLREAVIDVKNYPPGKKPSGNVKVYGAVGMMPIELQKEICK QYQKARLDFTAANHGSLGIFTPSSTEEDDGLRNRKVGEQKVQTSL |
| - |
| Nucleotide Sequence: 1818 bp [Download] |
| >gi|295815281|ref|NC_009494.2|:c2551538-2549721 Legionella pneumophila str. Corby chromosome, complete genome ATGTTCGGTTTTATTTCAGATTTATTAACAGCAGCAGTCAGTTCTTTAGATGAATTATTACAAGATACTC CGGCACATCAAATCATATTAGGCACAGCTGCTCTTTATTTTCTTTATAATCAATACCATAACCCATCGAT TTCCAGGTGGTACCGTAGCCGCAATAACGCCAGTATGAAGCAGCGTATTATTGATAGTGCTTACGCCTTG GCAAAAAATTTACCTGGTGTGAATCAGATCATTGAGAAAGAGCTCAATAAAGAACTCTCTTCAACGAGAG AAAAATTGAGAATTCAGCGTTCCGGTATGACTCTCAGGGAGGAAATACCTGAGGAAGGGCTTTCTCCCCA AGATATTTTGAGTGCATTTGATGTGGATGTGGAAAAATGTCATTTTGATTTTTTATCCGTAACTAATGAC AGCCCTGAGAGGGAGTTTCTTGTTGGAAGAGGGGATGGTAAAGATTCAGGTGCATTATACGCTATTCACC CTAAGGAACTGACAGAGCTGCTTAAAGAAGTTTATGGGGCAACCGCTCTAACTAATCCTTTGCATGATAA ATGGCCTCGAATTAACGCAATGCAAGCGGAGGTGATTCGCTGGTGTCAAAATTTGTTTCATGGTTCAAAA GAAGGTTATGGTTTATTAACTCATGGGGGTACGACCAGCATTATTGAGGCGATGGCTGCTTATGTCATTC GCGCAAGGGCAAAAGGCATTGATTATCCTGAAATTGTCGTTCCTGAAACAGCACATGCTGCATTTAAAAA AGCAGCCGAATTAACTGGAGCAATATTAATTACGGTTCCTGTTGATAAAAAAACGGGTGCGGTGAATCCC AATGTCATGAGTTCCTATATTACCAGAAACACTGCTGTAATGGTTGGATCTGCCCCATCGTTCATGAATG GAATTCATGATCCTGTCTCTGAGTTAGGTCAATTAGCAAAGAAAAAAAATGTTCCTTTTCATGTAGATGC CTGTTTGGGTGGGTTTTTAACGGCTTTTTTAGACACTTCATCCGAGCCTATGGATTTTCGAGTGCCTGGA GTGACTTCCATTTCAGCCGATTTGCATAAATATGGCTGTTGTCCAAAAGGCACCTCTGTTTGTCTTTTTA GTGAGGATTCGCCTGCTTTGTCGGTTTATGCCGCATTAAACTGGTCAGGTGGATTGTATGCTACGCCAGG AATTCTGGATGGTTCAACCAGTGGAGCTCGTGTCGCGGAAGTCTATGCTACATTGTCTTACTATGGGAAA AATAAATATCAGGAAATCGCCAAAAGCATTATCAGATTACGCAATGCTATTCAAAAAGAATTGACGACAT TAGTGGAAGAAGGCGCTGGATTAACCAGCGAGGATATTTATGTTTATGGTAATCCTCAATGGTCCATTCT GGGTTTTAGAAGTAACACTTGCAATGCCCATTTCATTGCAGATGAATTGGAGAAGCGGGGGTGGAAGCTT AACTTGCTACAAAATCCGGATGGGTTTCATTTATGTTTGACTCATGTGCACACTGTAGTAAAAGGTTTCG AAACGCAATTTATCAATGATTTAAGAGAGGCGGTGATTGATGTTAAAAATTATCCCCCTGGAAAGAAACC AAGTGGTAATGTCAAAGTGTATGGTGCTGTCGGTATGATGCCGATTGAGCTTCAGAAAGAAATTTGTAAA CAATATCAAAAAGCCCGCCTTGATTTTACAGCAGCCAACCACGGGAGCTTGGGGATATTTACACCTTCAT CTACAGAAGAGGACGATGGACTTAGAAACAGGAAAGTAGGGGAACAAAAAGTGCAAACCTCGCTTTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |