| Effector Protein ID: 148359674 |
 T4SS name [ID] | Dot/Icm [42] |
| Gene symbol | pof1 |
| Locus tag | LPC_1593 |
| Strain | Legionella pneumophila str. Corby |
| Replicon | chromosome [GenBank: NC_009494] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2473972..2474439 [+] |
| Product | F-box protein |
| Effector type | Protein |
| Descripton | AnkB/legAU13/ceg27 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkB is essential for Legionella-containing vacuole (LCV) acquisition of polyubiquitinated proteins in both macrophage and amoeba hosts |
| UniProt ID | A5IDT5 |
| KEGG ID | lpc:LPC_1593 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 6.2e-16, Aligned region: 45..105 Ank_2 [PF12796], Evalue: 6.2e-16, Aligned region: 46..116 Ank_4 [PF13637], Evalue: 6.1e-09, Aligned region: 44..96 |
| Protein Sequence: 155 a.a. [Download] |
| >gi|148359674|ref|YP_001250881.1| F-box protein [Legionella pneumophila str. Corby] MSFLKANTLGRIAQTCQFFNRLANDKHLELHQLRQQRIKRELWGNLMVAARSNNLEEVKKILKKGIDPAQ TNSYHLNRTPLLAAIEGKAYQTANYLWRKYTFDPNFKDNYGDSPISLLKKQLANPAFTDKEKKQIRALIR GMQEEKIAQSKCLVC |
| - |
| Nucleotide Sequence: 468 bp [Download] |
| >gi|295815281|ref|NC_009494.2|:2473972-2474439 Legionella pneumophila str. Corby chromosome, complete genome TTGAGTTTCTTAAAAGCAAACACACTAGGTCGTATAGCTCAGACATGTCAATTTTTTAATCGCTTGGCTA ATGATAAACATCTGGAACTGCATCAACTAAGACAACAACGTATAAAGCGAGAGCTATGGGGAAATCTTAT GGTGGCGGCAAGAAGCAATAACCTGGAAGAGGTCAAAAAGATTCTAAAAAAAGGAATCGATCCAGCCCAG ACCAATAGCTACCACTTAAATAGAACACCTTTACTTGCAGCTATCGAAGGAAAAGCATATCAAACTGCAA ATTACCTCTGGAGAAAATACACTTTCGATCCAAATTTTAAAGATAACTATGGTGATTCACCTATCTCTCT TCTTAAAAAGCAACTGGCAAATCCAGCCTTCACGGATAAGGAAAAAAAACAAATACGCGCCTTGATTAGG GGAATGCAAGAAGAAAAAATAGCACAGAGCAAGTGCCTTGTTTGTTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |