| Effector Protein ID: 148359013 |
 T4SS name [ID] | Dot/Icm [42] |
| Gene symbol | lok |
| Locus tag | LPC_0898 |
| Strain | Legionella pneumophila str. Corby |
| Replicon | chromosome [GenBank: NC_009494] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1700482..1702071 [+] |
| Product | serine/threonine-protein kinase |
| Effector type | Protein |
| Descripton | LegK1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | The canonical serine/threonine kinase activity of LegK1 is essential for potent activation of the NF-kB pathway. LegK1 mimics host IKK and directly phosphorylates the Ser32 and Ser36 residues of the inhibitory IkBa protein, leading to IkBa ubiquitination/degradation and subsequent nuclear translocation of p65. (Ge and Shao, 2011) |
| UniProt ID | A5IBX4 |
| KEGG ID | lpc:LPC_0898 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pkinase [PF00069], Evalue: 4.3e-27, Aligned region: 86..362 Pkinase_Tyr [PF07714], Evalue: 2.6e-14, Aligned region: 86..290 |
| Protein Sequence: 529 a.a. [Download] |
| >gi|148359013|ref|YP_001250220.1| serine/threonine-protein kinase [Legionella pneumophila str. Corby] MPRTMFFSVDAANLQNLQITNRKAFAALESYLNDNDSPGAWNNNQGYKYTHKDVTYCFSFNQSLVRRPRK SDQKKHTFEIFDPNKNPLGKGAYGIVYPILGAIQFEFGTAIKRPPKNKLVKIQNHSERDQSHSVLREYQG LLQSGHIAVKPPIFVENKESKFSYLIMEKAEGIVLEKFLNPVKRLDLSEEVPELNLINRIEITFAILKAI KEQVTDKHLIHRDIKPGNIIIDFSKSPPIAKVIDFGFVLRASEQDYRRCGTRAYRAPESFNTQALYTAKA DVWSTGRILSYLWGDKYTNYYISRDKGLDYVIEKSRNELLFSDPELELYLTKEDKSKIRSCLSAMLIVDP EERGSIDKAIKQFSQIDFEKYKRLKRSTNFEIDLTDNDIKLRKQLNSIHLHLITLQGKEKDLRDRACFDA ANAMSQLVSKLSTYTNYLEKNPDPFLIKRYKECCIAEIDLANLALQNHRDALWLVAELSTAILLLGIGYL FAFGINYYYTGRLGLFSQTRSEKLVEEMKSSVLGIAVGN |
| - |
| Nucleotide Sequence: 1590 bp [Download] |
| >gi|295815281|ref|NC_009494.2|:1700482-1702071 Legionella pneumophila str. Corby chromosome, complete genome ATGCCTCGTACAATGTTTTTTTCCGTTGATGCAGCTAATCTCCAAAATTTACAAATTACAAATCGAAAAG CTTTTGCAGCGTTGGAGAGTTATCTGAATGATAATGATTCACCAGGTGCCTGGAATAATAATCAAGGATA CAAATATACTCATAAGGATGTTACTTATTGCTTCTCATTTAATCAATCCTTAGTAAGACGCCCAAGAAAA TCGGATCAAAAAAAACATACATTTGAAATTTTTGACCCTAATAAGAACCCTTTAGGCAAGGGAGCGTACG GTATTGTCTATCCCATTTTAGGTGCAATTCAGTTTGAATTTGGAACCGCAATTAAAAGACCACCAAAGAA TAAATTAGTTAAAATACAAAACCATAGTGAACGCGATCAAAGTCATTCTGTACTACGTGAATATCAAGGG CTTCTTCAATCAGGGCATATAGCGGTTAAACCGCCAATATTTGTAGAAAACAAAGAGAGTAAATTCAGTT ACTTGATTATGGAAAAAGCGGAGGGTATCGTTTTAGAGAAGTTTCTAAATCCCGTTAAGCGGCTTGATTT GTCTGAAGAGGTACCCGAGCTTAATCTTATTAATCGGATTGAGATTACTTTTGCCATTTTAAAAGCAATT AAAGAACAGGTGACGGATAAGCATTTGATTCATCGAGATATAAAACCAGGAAATATTATAATCGATTTTA GCAAGTCACCTCCGATAGCTAAAGTAATCGATTTTGGTTTTGTGCTTAGGGCGTCAGAACAGGATTACCG TCGTTGTGGAACCCGAGCATACAGAGCGCCCGAATCTTTCAATACCCAGGCATTGTACACAGCAAAAGCT GATGTTTGGTCAACAGGCAGGATATTAAGTTATTTGTGGGGAGATAAATATACTAATTACTATATCTCTC GTGATAAGGGTTTGGACTACGTGATTGAGAAGTCAAGAAACGAACTACTCTTCTCTGACCCAGAATTGGA ACTCTATTTAACCAAGGAAGATAAAAGTAAAATCAGATCGTGCCTAAGCGCAATGCTTATAGTTGACCCT GAGGAAAGAGGATCTATAGATAAGGCTATCAAACAGTTTTCCCAAATTGATTTTGAAAAATATAAAAGAT TAAAGCGCTCTACAAATTTTGAAATTGATTTAACAGATAATGATATTAAATTAAGAAAACAGCTCAATTC AATTCACCTGCATTTGATTACCCTACAGGGCAAAGAAAAAGATTTGCGTGATAGAGCATGTTTTGATGCA GCGAATGCAATGAGCCAATTGGTTAGTAAGCTCTCTACCTACACCAATTATCTTGAAAAAAATCCAGATC CATTTTTAATAAAACGTTATAAAGAGTGCTGCATCGCAGAAATAGATTTAGCTAATTTGGCTTTGCAAAA TCACCGAGATGCTTTATGGTTGGTGGCTGAGTTATCAACTGCTATCCTTTTGCTTGGTATAGGGTATTTA TTTGCTTTTGGGATAAATTATTACTACACAGGTCGCCTGGGATTATTTTCTCAAACCAGGTCTGAGAAAT TGGTGGAAGAAATGAAAAGTTCGGTGTTAGGTATTGCGGTTGGAAATTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |