| Effector Protein ID: 108562949 |
 T4SS name [ID] | Cag [37] |
| Gene symbol | - |
| Locus tag | HPAG1_0524 |
| Strain | Helicobacter pylori HPAG1 |
| Replicon | chromosome [GenBank: NC_008086] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 546049..549651 [+] |
| Product | cytotoxin-associated protein A |
| Effector type | Protein |
| Descripton | CagA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | CagA can cause gastritis and peptic ulcer, Injected CagA can act as a ‘master key’ that evolved the ability to highjack multiple host cell signalling cascades, which include the induction of membrane dynamics, actin-cytoskeletal rearrangements and the disruption of cell-to-cell junctions as well as proliferative, pro-inflammatory and anti-apoptotic nuclear responses (Backert et al, 2010). |
| UniProt ID | Q1CTY1 |
| KEGG ID | hpa:HPAG1_0524 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | CagA [PF03507], Evalue: 5.9e-118, Aligned region: 864..915 CagA [PF03507], Evalue: 5.9e-118, Aligned region: 909..1071 |
| Protein Sequence: 1200 a.a. [Download] |
| >gi|108562949|ref|YP_627265.1| cytotoxin-associated protein A [Helicobacter pylori HPAG1] MTNETINQQPQTEAAFNPQQFINNLQVAFLKVDNAVVSYDPDQKPIVDKNDRDNRQAFDGISQLREEYSN KAIKNPTKKNQYFSDFINKSNDLINKDNLIDVESSTKSFQKFGDQRYRIFTSWVSHQNDPSKINTRSIRN FMENIIQPPIPDDKEKAEFLKSAKQSFAGIIIGNQIRTDQKFMGVFDEFLKERQEAEKNGGPTGGDWLDI FLSFIFDKKQSSDVKEAINQEPVPHVQPDIATTTTDIQGLPPESRDLLDERGNFSKFTLGDMEMLDVEGV ADIDPNYKFNQLLIHNNALSSVLMGSHDGIEPEKVSLLYGNNGGPEARHDWNATVGYKNQQGDNVATLIN VHMKNGSGLVIAGGEKGVNNPSFYLYKEDQLTGLKQALSQEEIRNKVDFMEFLAQNNAKLDNLSEKEKEK FQTEIKDFQKDSKAYLDALGNDRIAFVSKKDTKHSALLTEFGNGDLSYTLKDYGKKADKALDREKNVTLQ GNLKHDGVMFVDYSNFKYTNASKNPNKGVGVTNGVSHLEANLSKVAVFNLPNLNNLAITSYVRRDLEDKL WAKGLSPQEANKLIKDFLNSNKELVGKTLNFNKAVAEAKNTGDYDEVKKAHKDLEKSLRKREHLEKEVAK KLESKSGNKNKMEAKSQANSQKDEIFALINKEANRDARAIAYAQNLKGIKRELSDKLENINKDLKDFSKS FDEFKNGKNKDFSKTEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENS IKDVIINQKITDKADNLNQAVSVAKTTGDFSRVEQALADLKNFSKGQLAQQAQKNEDFNTGKNSELYQSV KNGVNKTLVGNGLSGIEATALAKNFSDIKKELNEKFKNFNNNNNNGLKNEPIYAKVNKKKTGQVASPEEP IYAKVNKKKTGQVASPEEPIYTQVAKKVNAKIDRLNQIASGLGGVGQAAGFPLKRHDKVDDLSKVGRSVS PEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSRNQELAQKIDNLNQAVSEAKAGFFGNLEQAIDKLKDST KHNPMNLWVESAKKVPASLSAKLDNYATNSHTRINSNIQNGAINEKVTGMLTQKNPEWLKLVNDKIVAHN VGSVPLSEYDRIGFNQKNMKDYSDSFKFSTKLNNAVKDIKSGFVQFLTNTFSTASYYCLAEENAKHGIKN ANTKGGFQKS |
| - |
| Nucleotide Sequence: 3603 bp [Download] |
| >gi|108562424|ref|NC_008086.1|:546049-549651 Helicobacter pylori HPAG1 chromosome, complete genome ATGACTAACGAAACCATTAACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAATA ATCTTCAAGTGGCTTTTCTTAAAGTTGATAACGCTGTCGTTTCATACGATCCTGATCAAAAACCAATCGT TGATAAGAACGATAGGGATAACAGGCAAGCTTTTGATGGAATCTCGCAATTAAGGGAAGAATACTCCAAT AAAGCGATCAAAAATCCTACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATCTAA TCAACAAAGACAATCTCATTGATGTAGAATCTTCCACAAAGAGCTTTCAGAAATTTGGGGATCAGCGTTA CCGAATTTTCACAAGTTGGGTGTCCCATCAAAACGATCCGTCTAAAATCAACACCCGATCGATCCGAAAT TTTATGGAAAATATCATACAACCCCCTATCCCTGATGACAAAGAAAAAGCAGAGTTTTTGAAATCTGCCA AACAATCTTTTGCAGGAATCATTATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGGCGTATTTGA TGAATTCTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGGGCCTACTGGTGGGGATTGGTTGGATATT TTTTTATCATTTATATTTGACAAAAAACAATCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTC CCCATGTCCAACCAGATATAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAATCTAGGGATTT GCTTGATGAAAGGGGTAATTTTTCTAAATTCACTCTTGGTGATATGGAAATGTTAGATGTTGAGGGTGTC GCTGACATTGATCCTAATTACAAGTTCAACCAATTATTGATTCACAATAACGCTCTGTCTTCTGTGTTAA TGGGGAGTCATGATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGGAAACAATGGTGGCCCTGAAGC TAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCGACAATGTGGCTACACTCATTAAT GTGCATATGAAAAACGGCAGTGGATTAGTCATAGCAGGTGGTGAGAAAGGGGTTAACAACCCTAGTTTTT ATCTCTACAAAGAAGACCAGCTCACAGGCTTGAAACAAGCATTGAGTCAAGAAGAGATCCGAAACAAAGT AGATTTCATGGAATTTCTTGCACAAAACAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAA TTCCAAACTGAGATTAAGGATTTCCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTA TTGCTTTTGTTTCTAAAAAAGACACAAAACATTCAGCTTTACTTACTGAGTTTGGTAATGGGGATTTGAG CTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCTTTAGATAGGGAGAAAAATGTTACTCTTCAA GGTAACCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAAATACACCAACGCCTCCAAGA ATCCCAATAAGGGTGTAGGCGTTACGAATGGCGTTTCCCATTTGGAAGCAAATCTTAGCAAGGTAGCTGT CTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAGTTATGTAAGGCGAGACTTAGAAGATAAACTG TGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTTATCAAAGACTTTTTGAATAGCAACAAAGAAT TGGTTGGAAAAACTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCGACTATGATGAAGT GAAAAAAGCTCATAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTGGAGAAAGAAGTAGCGAAA AAATTGGAGAGTAAAAGCGGCAACAAAAATAAAATGGAAGCGAAATCTCAAGCTAACAGCCAAAAAGATG AGATTTTTGCGTTGATCAATAAAGAGGCTAATAGAGACGCAAGAGCAATCGCTTACGCTCAAAATCTTAA AGGCATCAAAAGGGAATTGTCTGATAAACTTGAAAATATCAACAAGGATTTGAAAGACTTTAGTAAATCT TTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGACAGAAGAAACGCTAAAAGCCCTTAAAG GCTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAA TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAAATTCC ATTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGCTGACAATCTCAATCAAGCGGTATCAGTGG CTAAAACAACGGGTGATTTCAGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAATTTCTCAAAAGGACA ATTGGCCCAACAAGCTCAAAAAAATGAAGATTTCAATACTGGAAAAAATTCTGAACTATACCAATCCGTT AAGAATGGTGTAAATAAAACCCTAGTCGGTAATGGGTTATCTGGAATAGAGGCCACAGCTCTCGCCAAAA ATTTTTCGGATATCAAGAAAGAATTGAATGAGAAATTTAAAAATTTCAACAACAATAACAATAATGGACT CAAAAACGAACCCATTTATGCTAAAGTCAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAACCC ATTTATGCTAAAGTCAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAACCCATTTATACTCAAG TTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTGGTTTGGGTGGTGTAGGGCA AGCAGCGGGCTTCCCTTTGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCGATCAGTTAGC CCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATGATAAAGTTG ATGATCTCAGTAAGGTAGGGCTTTCAAGGAATCAAGAATTGGCTCAGAAAATTGACAATCTCAACCAGGC GGTATCAGAAGCTAAAGCAGGTTTTTTTGGCAATCTAGAACAAGCGATAGACAAGCTCAAAGATTCTACA AAGCACAATCCCATGAATCTATGGGTTGAAAGTGCAAAAAAAGTACCTGCTAGTTTGTCAGCGAAACTAG ATAATTATGCTACTAACAGCCACACACGCATTAATAGCAATATCCAAAATGGAGCAATCAATGAAAAAGT GACCGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAAT GTGGGAAGCGTTCCTTTGTCAGAGTATGATAGAATTGGCTTCAACCAGAAGAATATGAAAGATTATTCTG ATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCTGTAAAAGACATTAAGTCTGGCTTTGTGCAATTTTT AACCAATACATTTTCTACAGCATCTTATTACTGCTTGGCGGAAGAAAATGCGAAGCATGGAATCAAGAAC GCTAATACAAAAGGTGGTTTCCAAAAATCTTAA |
| Reference |
(1) Delgado-Rosado G; Dominguez-Bello MG; Massey SE (2011). Positive selection on a bacterial oncoprotein associated with gastric cancer. Gut Pathog. 3:18. [PudMed:22078307] 
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| experimental literature |