T4SS ID	686
Strain	Proteus mirabilis HI4320
Replicon	chromosome [Browse all T4SS(s) in this replicon]
Accession	NC_010554
Location	2807168..2829916
Name	Tfc
Function	conjugation
Classification	Type IVC; Type G
Experimental investigation has been performed on this T4SS.

T4SS components

Component	Tfc1	Tfc2	Tfc3	Tfc4	Tfc5	Tfc6	Tfc7	Tfc8	Tfc9
Number	0	1	1	1	1	1	0	1	1
Component	Tfc10	Tfc11	Tfc12	Tfc13	Tfc14	Tfc15	Tfc16	Tfc17	Tfc18
Number	0	1	1	1	1	1	1	0	0
Component	Tfc19	Tfc20	Tfc21	Tfc22	Tfc23	Tfc24
Number	1	0	0	1	1	1

The information of T4SS components from NC_010554
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	PMI_RS12660	2802556..2802831 [-], 276	490359925	hypothetical protein
2	PMI_RS12665	2803267..2803878 [-], 612	446784404	SGNH/GDSL hydrolase family protein
3	PMI_RS12670	2803886..2804794 [-], 909	490372693	integrase domain-containing protein
4	PMI_RS12675	2805837..2806076 [-], 240	490366075	hypothetical protein
5	PMI_RS12680	2806076..2806375 [-], 300	490366076	hypothetical protein
6	PMI_RS12685	2806718..2807125 [+], 408	490359931	DUF3742 family protein
7	PMI_RS12690	2807168..2808682 [-], 1515	446911667	conjugal transfer protein TraG
8	PMI_RS12695	2808679..2809017 [-], 339	446082369	hypothetical protein
9	PMI_RS12700	2809018..2810460 [-], 1443	446896562	integrating conjugative element protein
10	PMI_RS12705	2810475..2811449 [-], 975	501336800	TIGR03756 family integrating conjugative element protein	Tfc23
11	PMI_RS12710	2811446..2811886 [-], 441	490359936	TIGR03757 family integrating conjugative element protein	Tfc24
12	PMI_RS12715 (taaP)	2811965..2814190 [-], 2226	501336801	trimeric autotransporter adhesin TaaP
13	PMI_RS12720	2814285..2817152 [-], 2868	490359938	conjugative transfer ATPase	Tfc16
14	PMI_RS12725	2817152..2817589 [-], 438	490366080	TIGR03751 family conjugal transfer lipoprotein	Tfc15
15	PMI_RS12730	2817586..2818071 [-], 486	490359942	hypothetical protein
16	PMI_RS12735	2818068..2819564 [-], 1497	490359943	TIGR03752 family integrating conjugative element protein	Tfc14
17	PMI_RS12740	2819561..2820457 [-], 897	445945891	TIGR03749 family integrating conjugative element protein	Tfc13
18	PMI_RS12745	2820454..2821098 [-], 645	445955297	TIGR03746 family integrating conjugative element protein	Tfc12
19	PMI_RS12750	2821091..2821507 [-], 417	490359945	TIGR03750 family conjugal transfer protein	Tfc11
20	PMI_RS12755	2821520..2821888 [-], 369	490372720	TIGR03745 family integrating conjugative element membrane protein
21	PMI_RS12760	2821930..2822169 [-], 240	446992769	TIGR03758 family integrating conjugative element protein
22	PMI_RS12765	2822166..2822492 [-], 327	447159044	RAQPRD family integrative conjugative element protein	Tfc9
23	PMI_RS12770	2822639..2823247 [+], 609	490359950	DUF2913 family protein
24	PMI_RS12775	2823335..2824084 [-], 750	446101582	TIGR03747 family integrating conjugative element membrane protein	Tfc8
25	PMI_RS12780 (traD)	2824071..2826218 [-], 2148	501336802	type IV conjugative transfer system coupling protein TraD	Tfc6
26	PMI_RS12790	2826574..2827128 [-], 555	490366086	integrating conjugative element protein	Tfc5
27	PMI_RS12795	2827118..2827756 [-], 639	490359955	transglycosylase SLT domain-containing protein	Tfc4
28	PMI_RS12800	2827769..2828503 [-], 735	446712780	TIGR03759 family integrating conjugative element protein
29	PMI_RS12805	2828517..2829257 [-], 741	446071870	hypothetical protein
30	PMI_RS12810	2829254..2829916 [-], 663	490359957	PilL N-terminal domain-containing protein	Tfc2
31	PMI_RS12815 (tnpA)	2830088..2830525 [-], 438	pseudogene	IS200/IS605 family transposase
32	PMI_RS12820	2830683..2832671 [-], 1989	446350327	TonB-dependent receptor
33	PMI_RS12825	2832928..2834157 [+], 1230	446896978	MFS transporter

Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files

Proteins        Genes

This T4SS is encoded by the integrative and conjugative element (ICE) ICEPm1 and is thought to contribute to the transfer of this element. (click on the ICE name to view the detail ICE informaion in ICEberg, an ICE database)

(1) Flannery EL; Antczak SM; Mobley HL (2011). Self-transmissibility of the integrative and conjugative element ICEPm1 between clinical isolates requires a functional integrase, relaxase, and type IV secretion system. J Bacteriol. 193(16):4104-12. [PudMed:21665966]

(2) Pearson MM; Sebaihia M; Churcher C; Quail MA; Seshasayee AS; Luscombe NM; Abdellah Z; Arrosmith C; Atkin B; Chillingworth T; Hauser H; Jagels K; Moule S; Mungall K; Norbertczak H; Rabbinowitsch E; Walker D; Whithead S; Thomson NR; Rather PN; Parkhill J; Mobley HL (2008). Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility. J Bacteriol. 190(11):4027-37. [PudMed:18375554]

This literature contains experimental investigation