SecReT4

T4SS
Effectors
References

T4SS ID	496
Strain	Anaplasma marginale str. St. Maries
Replicon	chromosome [Browse all T4SS(s) in this replicon]
Accession	NC_004842
Location	23496..48535; 64841..78587; 175825..176214; 259077..259331; 659399..663547; 734837..75243; 900783..901468; 956209..963028; 1034507..1034896; 1113315..1114010; 1154957..1161340
Name	VirB
Function	effector translocation
Classification	Type IVA; Type P
Experimental investigation has been performed on this T4SS.

T4SS components

Component	VirB1	VirB2	VirB3	VirB4	VirB5	VirB6	VirB7	VirB8	VirB9
Number	0	22	1	2	0	4	1	1	2
Component	VirB10	VirB11	VirD4
Number	1	1	1

The information of T4SS components from NC_004842
Region 1: 23496..48535

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM026	21386..22900 [+], 1515	56416391	monovalent cation/H+ antiporter subunit D
2	AM027	22915..23301 [-], 387	56416392	hypothetical protein
3	AM030 (orfX)	23496..23882 [-], 387	56416393	hypothetical protein	VirB2
4	AM032 (orfY)	23955..24188 [-], 234	56416394	hypothetical protein	VirB2
5	AM034	25004..27445 [-], 2442	56416395	hypothetical protein
6	AM035	27643..27852 [+], 210	56416396	hypothetical protein
7	AM037 (thiG)	27915..28709 [+], 795	56416397	thiazole synthase
8	AM038	28807..29247 [-], 441	56416398	hypothetical protein
9	AM039 (gltX)	29429..30754 [+], 1326	56416399	glutamyl-tRNA synthetase
10	AM041	31186..32391 [+], 1206	56416400	hypothetical protein
11	AM042	32410..32967 [+], 558	56416401	hypothetical protein
12	AM044 (orfX)	33143..33541 [-], 399	56416402	hypothetical protein	VirB2
13	AM046 (orfY)	33614..33847 [-], 234	56416403	hypothetical protein	VirB2
14	AM051 (rho)	36761..38125 [-], 1365	56416404	transcription termination factor Rho
15	AM052	38234..38851 [-], 618	56416405	hypothetical protein
16	AM053 (rpmI)	39269..39469 [+], 201	56416406	50S ribosomal protein L35
17	AM054 (rplT)	39496..39882 [+], 387	56416407	50S ribosomal protein L20
18	AM055 (pheS)	39845..40900 [+], 1056	56416408	phenylalanyl-tRNA synthetase subunit alpha
19	AM056	40991..41749 [+], 759	56416409	hypothetical protein
20	AM058 (glmU)	41930..43216 [+], 1287	56416410	UDP-N-acetylglucosamine pyrophosphorylase
21	AM059 (rpsP)	43369..43638 [-], 270	56416411	30S ribosomal protein S16
22	AM060 (proP1)	43929..45215 [+], 1287	56416412	proline/betaine transport protein
23	AM063 (orfY)	47834..48067 [+], 234	56416413	hypothetical protein	VirB2
24	AM065 (orfX)	48140..48535 [+], 396	56416414	hypothetical protein	VirB2
25	AM069 (fpbA)	49429..50469 [+], 1041	56416415	iron binding protein FbpA precursor
26	AM070	50470..50649 [+], 180	56416416	hypothetical protein

Region 2: 64841..78587

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM073 (nrdR)	61443..61898 [-], 456	56416419	NrdR family transcriptional regulator
2	AM074	62431..62886 [+], 456	56416420	hypothetical protein
3	AM075 (omp14)	63055..64269 [+], 1215	56416421	outer membrane protein 14
4	AM077 (orfX)	64841..65242 [-], 402	56416422	hypothetical protein	VirB2
5	AM082 (orfX)	67571..67978 [+], 408	56416423	hypothetical protein	VirB2
6	AM085 (recA)	68810..69889 [+], 1080	56416424	recombinase A
7	AM087 (pyrE)	69984..70586 [+], 603	56416425	orotate phosphoribosyltransferase
8	AM088 (thiF)	70620..71426 [+], 807	56416426	thiamine biosynthesis protein
9	AM090 (msp4)	71782..72630 [-], 849	56416427	major surface protein 4
10	AM092	75388..76326 [-], 939	56416428	hypothetical protein
11	AM093	76411..76731 [-], 321	56416429	hypothetical protein
12	AM094	76781..76984 [+], 204	56416430	hypothetical protein
13	AM096 (trxA)	77419..77766 [-], 348	56416431	thioredoxin
14	AM097 (trbG)	77775..78587 [-], 813	56416432	conjugal transfer protein trbG precursor	VirB9
15	AM101 (pdhA)	78838..79956 [-], 1119	56416433	pyruvate dehydrogenase E1 component, subunit alpha precursor
16	AM102 (rrf)	79928..80869 [-], 942	56416434	hypothetical protein

Region 3: 175825..176214

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM203 (gshB)	170965..171891 [+], 927	56416507	glutathione synthetase
2	AM205 (ddl)	172027..173031 [+], 1005	56416508	D-alanine--D-alanine ligase
3	AM206 (ftsQ)	173024..173797 [+], 774	56416509	cell division protein
4	AM207 (ntrX)	174038..175438 [+], 1401	56416510	nitrogen assimilation regulatory protein
5	AM210 (orfX)	175825..176214 [+], 390	56416511	hypothetical protein	VirB2
6	AM215 (gor)	177599..179011 [-], 1413	56416512	glutathione reductase

Region 4: 259077..259331

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM299	254937..255290 [-], 354	56416573	hypothetical protein
2	AM301 (rpsD)	255537..256073 [+], 537	56416574	30S ribosomal protein S4
3	AM302	256490..257638 [-], 1149	56416575	hypothetical protein
4	AM303	257698..258471 [-], 774	56416576	hypothetical protein
5	AM305 (pgpA)	258486..259010 [-], 525	56416577	phosphatidylglycerophosphatase A
6	AM306	259077..259331 [-], 255	56416578	hypothetical protein	VirB7
7	AM308 (tig)	259718..261118 [+], 1401	56416579	trigger factor
8	AM309 (clpP)	261123..261770 [+], 648	56416580	ATP-dependent Clp protease proteolytic subunit
9	AM310 (clpX)	261780..262997 [+], 1218	56416581	ATP-dependent protease ATP-binding subunit ClpX

Region 5: 659399..663547

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM715	658530..658817 [-], 288	56416858	hypothetical protein
2	AM717 (orfX)	659399..659770 [-], 372	56416859	hypothetical protein	VirB2
3	AM721 (orfY)	662843..663076 [+], 234	56416860	hypothetical protein	VirB2
4	AM723 (orfX)	663149..663547 [+], 399	56416861	hypothetical protein	VirB2
5	AM730 (typA)	664842..666701 [-], 1860	56416862	GTP-binding protein

Region 6: 734837..75243

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM804 (ispH)	730871..731899 [+], 1029	56416914	4-hydroxy-3-methylbut-2-enyl diphosphate reductase
2	AM805 (dut)	732101..732544 [+], 444	56416915	deoxyuridine 5'triphosphate nucleotidohydrolase
3	AM807 (murF)	732591..733982 [-], 1392	56416916	UDP-N-acetylmuramyl-tripeptide synthetase
4	AM809	734205..734822 [+], 618	56416917	hypothetical protein
5	AM810	734837..739900 [-], 5064	56416918	hypothetical protein	VirB6
6	AM811	739863..743978 [-], 4116	56416919	hypothetical protein	VirB6
7	AM812	743990..747049 [-], 3060	56416920	hypothetical protein	VirB6
8	AM813 (virB6)	747102..749738 [-], 2637	56416921	VirB6 protein	VirB6
9	AM814 (virB4)	749731..752139 [-], 2409	56416922	type IV secretion system ATPase VirB4	VirB4
10	AM815 (virB3)	752143..752439 [-], 297	56416923	type IV secretion system protein VirB3	VirB3
11	AM816 (sodB)	752533..753204 [-], 672	56416924	Fe superoxide dismutase
12	AM818 (pstA)	753368..754753 [+], 1386	56416925	phosphate ABC transporter
13	AM820 (lipA)	754976..755917 [-], 942	56416927	lipoyl synthase
14	AM821	756603..758225 [-], 1623	56416928	hypothetical protein
15	AM823	758458..762411 [-], 3954	56416929	hypothetical protein
16	AM824 (pycA)	762503..764491 [-], 1989	56416930	propionyl-CoA carboxylase subunit alpha
17	AM825 (sfhB)	764861..765844 [+], 984	56416931	sfhb-like protein
18	AM826 (rpmB)	765847..766251 [-], 405	56416932	50S ribosomal protein L28
19	AM827 (priA)	766755..768743 [-], 1989	56416933	primosomal protein N'
20	AM829	768961..769884 [-], 924	56416934	hypothetical protein
21	AM830	770010..770813 [-], 804	56416935	hypothetical protein
22	AM832	770910..772622 [-], 1713	56416936	hypothetical protein
23	AM833	772749..773276 [-], 528	56416937	hypothetical protein
24	AM836	773664..774524 [-], 861	56416938	hypothetical protein
25	AM837 (era)	774500..775393 [-], 894	56416939	GTP-binding protein Era
26	AM839 (ffh)	775488..776843 [-], 1356	56416940	signal recognition particle protein
27	AM840 (nuoL3)	776836..778386 [-], 1551	56416941	monovalent cation/H+ antiporter subunit D
28	AM841	778461..778937 [-], 477	56416942	hypothetical protein
29	AM842 (dnaK)	779164..781101 [-], 1938	56416943	molecular chaperone DnaK
30	AM844 (rne)	781301..783160 [-], 1860	56416944	ribonuclease E
31	AM846	783255..783581 [-], 327	56416945	monovalent cation/H+ antiporter subunit C
32	AM847	783668..784144 [-], 477	56416946	monovalent cation/H+ antiporter subunit B
33	AM848	784101..784670 [-], 570	56416947	monovalent cation/H+ antiporter subunit B
34	AM849	784671..784970 [-], 300	56416948	monovalent cation/H+ antiporter subunit G
35	AM851	784977..785231 [-], 255	56416949	monovalent cation/H+ antiporter subunit F
36	AM852 (tktA)	785249..787234 [-], 1986	56416950	transketolase
37	AM853	787250..788854 [-], 1605	56416951	hypothetical protein
38	AM854	789000..789710 [+], 711	56416952	hypothetical protein
39	AM856 (purA)	790004..791341 [+], 1338	56416953	adenylosuccinate synthetase
40	AM858	791345..792331 [-], 987	56416954	hypothetical protein
41	AM859	792369..792863 [-], 495	56416955	hypothetical protein
42	AM860 (nrdA)	792908..794728 [-], 1821	56416956	ribonucleotide-diphosphate reductase subunit alpha
43	AM861 (ispA)	795296..796171 [+], 876	56416957	geranyltranstransferase (farnesyl-diphosphate synthase)
44	AM862	796220..797116 [+], 897	56416958	hypothetical protein
45	AM863 (thiO)	797146..798135 [-], 990	56416959	thiamine biosynthesis oxidoreductase
46	AM865 (dnaB)	798415..799890 [-], 1476	56416960	replicative DNA helicase
47	AM867	799944..800618 [-], 675	56416961	hypothetical protein
48	AM868 (ssnA)	800782..801246 [+], 465	56416962	cytosine deaminase
49	AM869 (fabH)	801378..802346 [-], 969	56416963	3-oxoacyl-ACP synthase
50	AM870 (plsX)	802346..803389 [-], 1044	56416964	glycerol-3-phosphate acyltransferase PlsX
51	AM870.5 (rpmF)	803389..803565 [-], 177	56416965	50S ribosomal protein L32
52	AM871 (tgt)	803779..805041 [+], 1263	56416966	queuine tRNA-ribosyltransferase
53	AM872 (pstB)	805237..806061 [-], 825	56416967	phosphate ABC transporter ATP-binding protein
54	AM873 (dapB)	806001..806843 [-], 843	56416968	dihydrodipicolinate reductase
55	AM875	806956..807441 [-], 486	56416969	hypothetical protein
56	AM876 (ubiA)	807454..808353 [-], 900	56416970	4-hydroxybenzoate polyprenyltransferase
57	AM878 (aaaP)	808427..809686 [-], 1260	56416971	appendage-associated protein
58	AM879	809841..811124 [-], 1284	56416972	hypothetical protein
59	AM880	811267..812109 [-], 843	56416973	hypothetical protein
60	AM880.5 (rpmH)	812267..812401 [+], 135	56416974	50S ribosomal protein L34
61	AM881	812407..812766 [+], 360	56416975	hypothetical protein
62	AM882	812779..814098 [+], 1320	56416976	hypothetical protein
63	AM884	814157..816403 [-], 2247	56416977	hypothetical protein
64	AM885 (pheT)	816685..819048 [-], 2364	56416978	phenylalanyl-tRNA synthetase subunit beta
65	AM886 (rplQ)	819052..819456 [-], 405	56416979	50S ribosomal protein L17
66	AM887 (rpoA)	819497..820597 [-], 1101	56416980	DNA-directed RNA polymerase subunit alpha
67	AM888 (rpsK)	820618..820992 [-], 375	161544985	30S ribosomal protein S11
68	AM890 (rpsM)	821002..821373 [-], 372	56416982	30S ribosomal protein S13
69	AM891 (adk)	821437..822087 [-], 651	56416983	adenylate kinase
70	AM892 (secY)	822069..823370 [-], 1302	56416984	preprotein translocase subunit SecY
71	AM893 (rplO)	823394..823834 [-], 441	56416985	50S ribosomal protein L15
72	AM894 (rpsE)	823848..824372 [-], 525	56416986	30S ribosomal protein S5
73	AM895 (rplR)	824383..824760 [-], 378	56416987	50S ribosomal protein L18
74	AM896 (rplF)	824762..825307 [-], 546	56416988	50S ribosomal protein L6
75	AM897 (rpsH)	825319..825717 [-], 399	56416989	30S ribosomal protein S8
76	AM898 (rpsN)	825735..825983 [-], 249	56416990	small ribosomal protein S14
77	AM899 (rplE)	826052..826591 [-], 540	56416991	50S ribosomal protein L5
78	AM900 (rplX)	826592..826909 [-], 318	56416992	50S ribosomal protein L24
79	AM901 (rplN)	826906..827265 [-], 360	56416993	50S ribosomal protein L14
80	AM903 (rpsQ)	827278..827511 [-], 234	56416994	30S ribosomal protein S17
81	AM904 (rpmC)	827501..827707 [-], 207	56416995	50S ribosomal protein L29
82	AM905 (rplP)	827715..828131 [-], 417	161544984	50S ribosomal protein L16
83	AM906 (rpsC)	828140..828775 [-], 636	56416997	30S ribosomal protein S3
84	AM907 (rplV)	828779..829117 [-], 339	56416998	50S ribosomal protein L22
85	AM908 (rpsS)	829121..829402 [-], 282	56416999	30S ribosomal protein S19
86	AM909 (rplB)	829408..830241 [-], 834	56417000	50S ribosomal protein L2
87	AM910 (rplW)	830238..830546 [-], 309	56417001	50S ribosomal protein L23
88	AM911 (rplD)	830521..831147 [-], 627	56417002	50S ribosomal protein L4
89	AM912 (rplC)	831165..831863 [-], 699	56417003	50S ribosomal protein L3
90	AM913 (rpsJ)	831865..832182 [-], 318	56417004	30S ribosomal protein S10
91	AM914 (tuf)	832189..833370 [-], 1182	56417005	elongation factor Tu
92	AM915	833746..834531 [+], 786	56417006	hypothetical protein
93	AM916 (cmk)	834518..835195 [+], 678	56417007	cytidylate kinase
94	AM917 (rpsA)	835260..836939 [+], 1680	56417008	30S ribosomal protein S1
95	AM918 (sppA)	836943..837824 [+], 882	56417009	protease IV
96	AM919	838073..838570 [+], 498	56417010	hypothetical protein
97	AM920	838571..839008 [+], 438	56417011	hypothetical protein
98	AM921	839324..840277 [+], 954	56417012	hypothetical protein
99	AM922 (hemH)	840581..841633 [+], 1053	56417013	ferrochelatase
100	AM923	841636..842700 [-], 1065	56417014	hypothetical protein
101	AM924	842956..843282 [-], 327	56417015	hypothetical protein
102	AM925 (hflK)	843819..844742 [-], 924	56417016	HFLK protein
103	AM926	844805..845653 [-], 849	56417017	hypothetical protein
104	AM927	845751..848354 [+], 2604	56417018	hypothetical protein
105	AM928 (qor)	848679..849662 [-], 984	56417019	quinone oxidoreductase
106	AM929	849768..852170 [-], 2403	56417020	hypothetical protein
107	AM931 (folP)	852504..853310 [+], 807	56417021	dihydropteroate synthase
108	AM933 (carB)	853769..857077 [+], 3309	56417022	carbamoyl phosphate synthase large subunit
109	AM936	858293..858685 [-], 393	56417023	hypothetical protein
110	AM937 (fumC)	858850..860238 [-], 1389	56417024	fumarate hydratase
111	AM938	860408..861058 [+], 651	56417025	hypothetical protein
112	AM939 (pyrC)	861059..862423 [+], 1365	56417026	dihydroorotase
113	AM940 (glmM)	862557..863915 [-], 1359	56417027	phosphoglucosamine mutase
114	AM941 (lipB)	863952..864596 [-], 645	56417028	lipoyltransferase
115	AM942 (radC)	864687..865379 [-], 693	56417029	DNA repair protein
116	AM943 (groES)	865600..865884 [+], 285	161544983	co-chaperonin GroES
117	AM944 (groEL)	865932..867581 [+], 1650	56417031	chaperonin GroEL
118	AM947	868196..868927 [-], 732	56417032	hypothetical protein
119	AM949 (clpB)	869149..871767 [+], 2619	56417033	ATP-dependent Clp protease ATP-binding subunit
120	AM950	871879..873540 [-], 1662	56417034	hypothetical protein
121	AM952	873771..874763 [-], 993	56417035	hypothetical protein
122	AM953	874868..875608 [-], 741	56417036	hypothetical protein
123	AM955	875813..876211 [+], 399	56417037	hypothetical protein
124	AM956 (pepA)	876183..877787 [+], 1605	56417038	leucyl aminopeptidase
125	AM957	877803..878447 [+], 645	56417039	hypothetical protein
126	AM959	878594..880069 [-], 1476	56417040	hypothetical protein
127	AM960 (purQ)	880211..880993 [-], 783	56417041	phosphoribosylformylglycinamidine synthase
128	AM961 (gidA)	881074..882987 [+], 1914	56417042	tRNA uridine 5-carboxymethylaminomethyl modification protein GidA
129	AM964 (glpX)	883300..884265 [-], 966	56417043	fructose 1,6-bisphosphatase II
130	AM965	884352..885053 [+], 702	56417044	hypothetical protein
131	AM967	885213..885668 [+], 456	56417045	hypothetical protein
132	AM968	885769..886053 [+], 285	56417046	hypothetical protein
133	AM969 (bioB)	886040..887014 [+], 975	56417047	biotin synthase
134	AM973 (purL)	887742..890792 [+], 3051	56417048	phosphoribosylformylglycinamidine synthase
135	AM974	890823..891029 [+], 207	56417049	hypothetical protein
136	AM975	891166..891870 [+], 705	56417050	hypothetical protein
137	AM976	891926..892141 [-], 216	56417051	hypothetical protein
138	AM977	892150..892698 [-], 549	56417052	hypothetical protein
139	AM979	892797..894077 [-], 1281	56417053	hypothetical protein
140	AM980	894252..894620 [+], 369	56417054	hypothetical protein
141	AM981	894865..895755 [+], 891	56417055	hypothetical protein
142	AM982	895993..896646 [-], 654	56417056	hypothetical protein
143	AM983 (purM)	896760..897815 [+], 1056	56417057	phosphoribosylaminoimidazole synthetase
144	AM984 (xerC)	897807..898757 [-], 951	56417058	integrase/recombinase ripx
145	AM985 (gpsA)	898926..900095 [+], 1170	56417059	gylcerol-3-phosphate dehydrogenase
146	AM987 (omp15)	900092..900547 [+], 456	56417060	outer membrane protein 15
147	AM989 (orfX)	900783..901157 [-], 375	56417061	hypothetical protein	VirB2
148	AM990 (orfY)	901157..901468 [-], 312	56417062	hypothetical protein	VirB2
149	AM992 (rho)	901852..903234 [-], 1383	56417063	transcription termination factor Rho
150	AM997	903504..903842 [-], 339	56417064	hypothetical protein
151	AM998 (hslV)	904024..904593 [+], 570	56417065	ATP-dependent protease peptidase subunit
152	AM999 (hslU)	904590..906038 [+], 1449	56417066	ATP-dependent protease ATP-binding subunit HslU
153	AM1000 (ubiE)	906042..906785 [+], 744	56417067	ubiquinone/menaquinone biosynthesis methyltransferase
154	AM1001 (metS)	906786..908153 [-], 1368	56417068	methionyl-tRNA synthetase
155	AM1005 (lysC)	908599..909837 [+], 1239	56417069	aspartate kinase
156	AM1006	909871..910086 [-], 216	56417070	hypothetical protein
157	AM1007 (coxB)	910094..910924 [+], 831	56417071	cytochrome C oxidase subunit II
158	AM1008 (coxA)	911021..912586 [+], 1566	56417072	cytochrome C oxidase subunit I
159	AM1009 (ctaB)	912596..913501 [+], 906	56417073	protoheme IX farnesyltransferase
160	AM1010	913554..914480 [-], 927	56417074	hypothetical protein
161	AM1011 (purD)	914624..915886 [+], 1263	56417075	phosphoribosylamine--glycine ligase
162	AM1012 (yajC)	915917..916423 [+], 507	56417076	preprotein translocase subunit
163	AM1013 (glmS)	916492..918318 [+], 1827	56417077	glucosamine--fructose-6-phosphate aminotransferase
164	AM1014 (dnaN)	918685..919824 [-], 1140	56417078	DNA polymerase III subunit beta
165	AM1015 (rnd)	920045..920659 [-], 615	56417079	ribonuclease D
166	AM1016 (czcR)	920724..921596 [-], 873	56417080	transcriptional activator protein
167	AM1018	921897..922544 [-], 648	56417081	hypothetical protein
168	AM1020 (ppa)	923388..923915 [-], 528	56417082	inorganic phosphatase protein
169	AM1021	924979..925203 [-], 225	56417083	hypothetical protein
170	AM1022 (rpsI)	925139..925600 [-], 462	56417084	30S ribosomal protein S9
171	AM1023 (rplM)	925572..926084 [-], 513	56417085	50S ribosomal protein L13
172	AM1024 (tolC)	926120..927517 [+], 1398	56417086	outer membrane protein
173	AM1025	927536..928129 [+], 594	56417087	hypothetical protein
174	AM1027	928257..929288 [-], 1032	56417088	hypothetical protein
175	AM1028 (prsA)	929392..930171 [+], 780	56417089	phosphoribosylpyrophosphate synthetase
176	AM1030	930364..930684 [+], 321	56417090	hypothetical protein
177	AM1032 (acnA)	930720..933356 [-], 2637	161544982	aconitate hydratase
178	AM1035 (apaG)	933744..934196 [-], 453	56417092	ApaG protein
179	AM1036 (purK)	934272..935342 [+], 1071	56417093	phosphoribosylaminoimidazole carboxylase
180	AM1037	935472..937625 [-], 2154	56417094	hypothetical protein
181	AM1041	938242..939717 [+], 1476	56417095	hypothetical protein
182	AM1046	940029..941474 [+], 1446	56417096	hypothetical protein
183	AM1048	941505..945434 [-], 3930	56417097	hypothetical protein
184	AM1050	945638..949768 [-], 4131	56417098	hypothetical protein
185	AM1051	950058..955655 [-], 5598	56417099	hypothetical protein
186	AM1053 (virB4)	956209..958638 [-], 2430	56417100	VirB4 protein	VirB4
187	AM1054	958771..959145 [-], 375	56417101	hypothetical protein	VirB2
188	AM1055	959418..959795 [-], 378	56417102	hypothetical protein	VirB2
189	AM1056	960582..961172 [-], 591	56417103	hypothetical protein	VirB2
190	AM1057	961182..961730 [-], 549	56417104	hypothetical protein
191	AM1058	961959..962324 [+], 366	56417105	hypothetical protein
192	AM1059 (orfY)	962297..962566 [+], 270	56417106	hypothetical protein	VirB2
193	AM1061 (orfX)	962633..963028 [+], 396	56417107	hypothetical protein	VirB2
194	AM1063 (msp3)	963365..966196 [+], 2832	56417108	major surface protein 3
195	AM1064 (hflK)	966443..967555 [+], 1113	56417109	hflK protein
196	AM1065 (hflC)	967557..968429 [+], 873	56417110	hflC protein
197	AM1066	968432..969895 [+], 1464	56417111	hypothetical protein
198	AM1067	969888..970502 [+], 615	56417112	hypothetical protein
199	AM1069 (rnc)	970489..971187 [+], 699	56417113	ribonuclease III
200	AM1070 (cox11)	971218..971841 [+], 624	56417114	cytochrome C oxidase assembly protein
201	AM1073	971851..972633 [-], 783	56417115	hypothetical protein
202	AM1076 (ana29)	972972..973766 [-], 795	56417116	hypothetical protein
203	AM1077	973899..974120 [+], 222	56417117	hypothetical protein
204	AM1078	974177..975052 [-], 876	56417118	hypothetical protein
205	AM1079	975249..976583 [-], 1335	56417119	hypothetical protein
206	AM1080	976596..978017 [-], 1422	56417120	hypothetical protein
207	AM1081 (lspA)	977980..978492 [-], 513	56417121	lipoprotein signal peptidase
208	AM1082 (ribF)	978571..979482 [-], 912	56417122	riboflavin kinase / FAD synthetase protein
209	AM1083 (grxC1)	979550..979792 [+], 243	56417123	glutaredoxin
210	AM1084 (hemK)	979944..980801 [-], 858	56417124	protein-(glutamine-N5) methyltransferase
211	AM1086 (map)	980982..981779 [-], 798	56417125	methionine aminopeptidase
212	AM1087 (sucB)	981783..983096 [-], 1314	56417126	dihydrolipoamide acetyltransferase component
213	AM1088	983127..983516 [-], 390	56417127	hypothetical protein
214	AM1089 (panC)	983746..984645 [-], 900	56417128	pantoate--beta-alanine ligase
215	AM1091	984734..985876 [+], 1143	56417129	hypothetical protein
216	AM1092 (dsbD)	985863..987092 [-], 1230	56417130	cytochrome C biogenesis protein
217	AM1093	987136..987468 [-], 333	56417131	hypothetical protein
218	AM1094	987506..988609 [+], 1104	56417132	hypothetical protein
219	AM1096 (oma87)	988615..990954 [+], 2340	56417133	outer membrane protein
220	AM1097	990941..991501 [+], 561	56417134	hypothetical protein
221	AM1098 (fabZ)	991507..991950 [+], 444	56417135	(3R)-hydroxymyristoyl-ACP dehydratase
222	AM1099 (purH)	991965..993506 [+], 1542	56417136	phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase)
223	AM1100 (pgsA)	993515..994057 [-], 543	56417137	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
224	AM1103	994766..996070 [+], 1305	56417138	hypothetical protein
225	AM1104 (slt)	996098..998122 [+], 2025	56417139	soluble lytic murein transglycosylase precursor
226	AM1105 (surf1)	998129..998815 [-], 687	56417140	surfeit locus protein 1
227	AM1108	999373..1001166 [+], 1794	56417141	hypothetical protein
228	AM1109	1001259..1002611 [-], 1353	56417142	hypothetical protein
229	AM1110 (atpB)	1002680..1003483 [+], 804	56417143	F0F1 ATP synthase subunit A
230	AM1111	1003567..1004193 [-], 627	56417144	hypothetical protein
231	AM1112 (atpE)	1004848..1005072 [+], 225	161544981	F0F1 ATP synthase subunit C
232	AM1113	1005079..1005579 [+], 501	56417146	hypothetical protein
233	AM1114	1005576..1006073 [+], 498	56417147	hypothetical protein
234	AM1115 (ftsA)	1006198..1007472 [-], 1275	56417148	cell division protein FtsA
235	AM1116 (trkH)	1007504..1009075 [-], 1572	56417149	potassium uptake protein
236	AM1117 (mesJ)	1009146..1010651 [+], 1506	56417150	cell cycle protein
237	AM1119 (ftsH)	1010664..1012496 [+], 1833	56417151	cell division protein
238	AM1120 (secA)	1012689..1015307 [+], 2619	161544980	preprotein translocase subunit SecA
239	AM1121	1015158..1015364 [-], 207	56417153	hypothetical protein
240	AM1122	1015383..1016132 [-], 750	56417154	hypothetical protein
241	AM1123 (czcD)	1016136..1017089 [-], 954	56417155	cation efflux system protein
242	AM1125 (ccmB)	1017256..1017918 [-], 663	56417156	heme exporter protein B
243	AM1126 (dksA)	1018019..1018432 [+], 414	56417157	dnaK suppressor protein
244	AM1128 (dtbS)	1018760..1019443 [-], 684	56417158	dethiobiotin synthase
245	AM1129 (ftsY)	1019519..1020436 [+], 918	56417159	cell division protein
246	AM1131 (icd)	1020711..1022177 [+], 1467	56417160	isocitrate dehydrogenase
247	AM1133 (recJ)	1022302..1024062 [+], 1761	56417161	single-stranded-DNA-specific exonuclease
248	AM1135	1024037..1024336 [-], 300	56417162	hypothetical protein
249	AM1136 (pcnB)	1024527..1025786 [+], 1260	56417163	poly (A) polymerase
250	AM1137 (ndk)	1025923..1026363 [-], 441	56417164	nucleoside diphosphate kinase
251	AM1138	1026592..1027155 [+], 564	56417165	hypothetical protein
252	AM1139 (omp1)	1027570..1028562 [+], 993	56417166	outer membrane protein 1
253	AM1140 (opag3)	1028727..1029665 [+], 939	56417167	msp2 operon associated gene 3
254	AM1141	1028745..1029848 [-], 1104	56417168	hypothetical protein
255	AM1142 (opag2)	1029680..1030591 [+], 912	56417169	msp2 operon associated gene 2
256	AM1143 (opag1)	1030615..1031007 [+], 393	56417170	msp2 operon associated gene 1
257	AM1144 (msp2)	1031020..1032243 [+], 1224	56417171	major surface protein 2
258	AM1145	1032455..1032949 [-], 495	56417172	hypothetical protein
259	AM1146	1032906..1033490 [+], 585	56417173	hypothetical protein
260	AM1149 (orfX)	1034507..1034896 [-], 390	56417174	hypothetical protein	VirB2
261	AM1156 (omp2)	1038392..1039126 [-], 735	56417175	outer membrane protein 2
262	AM1159 (omp3)	1039207..1039857 [-], 651	56417176	outer membrane protein 3
263	AM1161	1039827..1040150 [+], 324	56417177	hypothetical protein
264	AM1164 (omp4)	1040420..1041637 [+], 1218	56417178	outer membrane protein 4
265	AM1165	1041615..1041863 [+], 249	56417179	hypothetical protein
266	AM1166 (omp5)	1041982..1043100 [+], 1119	56417180	outer membrane protein 5
267	AM1168	1043468..1044283 [-], 816	56417181	hypothetical protein
268	AM1169 (ccmF)	1044334..1046256 [-], 1923	56417182	cytochrome C-type biogenesis protein
269	AM1170 (valS)	1046615..1049086 [+], 2472	56417183	valyl-tRNA synthetase
270	AM1171 (smpB)	1049982..1050431 [-], 450	56417184	SsrA-binding protein
271	AM1172 (ribA)	1050434..1051066 [-], 633	56417185	3,4-dihydroxy-2-butanone 4-phosphate synthase
272	AM1173 (greA)	1051085..1051609 [-], 525	56417186	transcription elongation factor greA
273	AM1174 (atpA)	1051606..1053129 [-], 1524	56417187	F0F1 ATP synthase subunit alpha
274	AM1175 (atpH)	1053149..1053721 [-], 573	56417188	ATP synthase subunit delta
275	AM1179	1054297..1054548 [-], 252	56417189	hypothetical protein
276	AM1180	1054552..1055790 [-], 1239	56417190	hypothetical protein
277	AM1181	1055787..1056539 [-], 753	56417191	hypothetical protein
278	AM1183	1056544..1057770 [-], 1227	56417192	hypothetical protein
279	AM1185	1058051..1059100 [+], 1050	56417193	hypothetical protein
280	AM1186	1059095..1060324 [-], 1230	56417194	hypothetical protein
281	AM1187 (gltA)	1060680..1061933 [-], 1254	56417195	citrate synthase
282	AM1188 (guaA)	1061970..1063559 [-], 1590	56417196	GMP synthase
283	AM1189	1063676..1063906 [-], 231	56417197	hypothetical protein
284	AM1191	1064038..1064433 [+], 396	56417198	hypothetical protein
285	AM1192 (pdhC)	1065049..1066350 [+], 1302	56417199	branched-chain alpha-keto acid dehydrogenase E2 subunit
286	AM1193	1066507..1066761 [-], 255	56417200	hypothetical protein
287	AM1194 (fbaB)	1066669..1067568 [+], 900	161544979	fructose-bisphosphate aldolase
288	AM1196 (pbpA1)	1067822..1069627 [-], 1806	56417202	penicillin-binding protein
289	AM1197 (secF)	1069608..1070543 [-], 936	56417203	preprotein translocase subunit SecF
290	AM1200	1070689..1071069 [+], 381	56417204	hypothetical protein
291	AM1202 (hemA)	1071072..1072304 [-], 1233	56417205	5-aminolevulinate synthase
292	AM1205 (tyrS)	1072474..1073718 [-], 1245	56417206	tyrosyl-tRNA synthetase
293	AM1206 (glnA)	1074028..1075434 [+], 1407	56417207	glutamine synthetase
294	AM1207 (mraY)	1075445..1076473 [+], 1029	56417208	phospho-N-acetylmuramoyl-pentapeptide-transferase
295	AM1208 (ispB)	1076483..1077466 [+], 984	56417209	octaprenyl-diphosphate synthase
296	AM1209	1077541..1079622 [-], 2082	56417210	hypothetical protein
297	AM1210 (mkl)	1079749..1080468 [-], 720	56417211	ribonucleotide transport ATP-binding protein
298	AM1212	1080473..1081252 [-], 780	56417212	hypothetical protein
299	AM1213 (rpe)	1081271..1082053 [-], 783	56417213	ribulose-phosphate 3-epimerase
300	AM1214 (polA)	1082130..1084724 [-], 2595	56417214	DNA polymerase I
301	AM1216	1085541..1085927 [+], 387	56417215	hypothetical protein
302	AM1217 (argF)	1085950..1086858 [+], 909	56417216	ornithine carbamoyltransferase
303	AM1218 (recF)	1086868..1087983 [+], 1116	56417217	recombination protein F
304	AM1219 (omp6)	1087980..1088441 [-], 462	56417218	outer membrane protein 6
305	AM1220 (omp7)	1088481..1089671 [-], 1191	56417219	outer membrane protein 7
306	AM1221 (omp8)	1089736..1090935 [-], 1200	56417220	outer membrane protein 8
307	AM1222 (omp9)	1090999..1092210 [-], 1212	56417221	outer membrane protein 9
308	AM1223 (omp10)	1092273..1093535 [-], 1263	56417222	outer membrane protein 10
309	AM1225	1093976..1094518 [-], 543	56417223	hypothetical protein
310	AM1226	1094876..1095514 [+], 639	56417224	hypothetical protein
311	AM1228	1095979..1096902 [-], 924	56417225	hypothetical protein
312	AM1229 (mviN)	1097053..1098417 [-], 1365	56417226	virulence factor MVIN
313	AM1231 (lgt)	1098643..1099500 [+], 858	56417227	prolipoprotein diacylglyceryl transferase
314	AM1232	1099740..1099955 [+], 216	56417228	hypothetical protein
315	AM1233 (rpsT)	1100204..1100494 [-], 291	161544978	30S ribosomal protein S20
316	AM1235 (plsC)	1100613..1101338 [-], 726	56417230	1-acyl-sn-glycerol-3-phosphate acyltransferase
317	AM1236 (def)	1101370..1101927 [+], 558	56417231	N-formylmethionylaminoacyl-tRNA deformylase
318	AM1237	1102174..1103046 [+], 873	56417232	hypothetical protein
319	AM1238	1103188..1103916 [+], 729	56417233	hypothetical protein
320	AM1239	1104007..1104234 [-], 228	56417234	hypothetical protein
321	AM1240	1104293..1104499 [-], 207	56417235	hypothetical protein
322	AM1241	1104735..1105244 [-], 510	56417236	hypothetical protein
323	AM1242	1105289..1106398 [-], 1110	56417237	hypothetical protein
324	AM1243 (uvrB)	1106811..1108766 [-], 1956	56417238	excinuclease ABC subunit B
325	AM1245 (secD)	1108831..1110336 [+], 1506	56417239	preprotein translocase subunit SecD
326	AM1248	1110826..1112649 [+], 1824	56417240	hypothetical protein
327	AM1251 (orfY)	1113315..1113548 [+], 234	56417241	hypothetical protein	VirB2
328	AM1253 (orfX)	1113621..1114010 [+], 390	56417242	hypothetical protein	VirB2
329	AM1254	1114075..1115559 [-], 1485	56417243	hypothetical protein
330	AM1255 (omp11)	1115669..1116658 [-], 990	56417244	outer membrane protein 11
331	AM1257 (omp12)	1116852..1117709 [-], 858	56417245	outer membrane protein 12
332	AM1258 (omp13)	1117917..1118975 [-], 1059	56417246	outer membrane protein 13
333	AM1261 (ftsZ)	1119261..1120514 [+], 1254	56417247	cell division protein FtsZ
334	AM1264	1120891..1121355 [+], 465	56417248	hypothetical protein
335	AM1266 (parA)	1121429..1122244 [+], 816	56417249	chromosome partitioning protein
336	AM1267 (parB)	1122241..1123068 [+], 828	56417250	chromosome partitioning protein
337	AM1269 (rimM)	1123080..1123652 [+], 573	56417251	16S rRNA-processing protein RimM
338	AM1270 (trmD)	1123649..1124356 [+], 708	56417252	tRNA (guanine-N(1)-)-methyltransferase
339	AM1271 (rplS)	1124349..1124753 [+], 405	56417253	50S ribosomal protein L19
340	AM1272 (cinA)	1124760..1125281 [-], 522	56417254	competence / damage-inducible protein
341	AM1273 (thrS)	1125347..1127257 [+], 1911	56417255	threonyl-tRNA synthetase
342	AM1274 (infC)	1127287..1127820 [+], 534	56417256	translation initiation factor IF-3
343	AM1275	1128227..1128682 [-], 456	56417257	hypothetical protein
344	AM1276	1128686..1129387 [-], 702	56417258	hypothetical protein
345	AM1277 (asd)	1129505..1130515 [-], 1011	56417259	aspartate-semialdehyde dehydrogenase
346	AM1278	1130517..1130825 [-], 309	56417260	hypothetical protein
347	AM1280 (dnaZ)	1130831..1132255 [-], 1425	56417261	DNA polymerase III subunit gamma
348	AM1283 (gapB)	1132441..1133445 [-], 1005	56417262	NAD(P)-dependent glyceraldehyde 3-phosphate dehydrogenase
349	AM1285	1133834..1134778 [+], 945	56417263	hypothetical protein
350	AM1286	1134794..1135450 [+], 657	56417264	isoprenoid biosynthesis protein
351	AM1287 (ftsW)	1135475..1136632 [-], 1158	56417265	cell division protein
352	AM1288 (metK)	1136614..1137816 [-], 1203	56417266	S-adenosylmethionine synthetase
353	AM1289 (ubiH)	1138038..1139204 [+], 1167	56417267	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase
354	AM1292	1139216..1139824 [-], 609	56417268	hypothetical protein
355	AM1294 (glyQ)	1140100..1140951 [+], 852	56417269	glycyl-tRNA synthetase subunit alpha
356	AM1295 (glyS)	1140953..1143037 [+], 2085	56417270	glycyl-tRNA synthetase subunit beta
357	AM1296 (dnaJ)	1143119..1144258 [+], 1140	56417271	chaperone protein DnaJ
358	AM1297 (nadC)	1144277..1145095 [-], 819	56417272	nicotinate-nucleotide pyrophosphorylase
359	AM1298	1145154..1145750 [+], 597	56417273	membrane protein
360	AM1299 (ruvC)	1145742..1146239 [-], 498	56417274	holliday (crossover) junction endodeoxyribonuclease
361	AM1300 (coxC)	1146258..1147076 [-], 819	56417275	cytochrome C oxidase subunit III
362	AM1301 (hemE)	1147146..1147943 [-], 798	56417276	uroporphyrinogen decarboxylase
363	AM1303	1148564..1149445 [+], 882	56417277	hypothetical protein
364	AM1304	1149432..1149950 [-], 519	56417278	hypothetical protein
365	AM1305	1149934..1151130 [-], 1197	161544977	hypothetical protein
366	AM1306	1151233..1152033 [+], 801	56417280	hypothetical protein
367	AM1307 (nadA)	1152053..1153009 [+], 957	56417281	quinolinate synthetase
368	AM1309 (fdxA)	1153031..1153402 [-], 372	56417282	ferredoxin II
369	AM1310 (ilvC)	1153528..1154499 [+], 972	56417283	ketol-acid reductoisomerase
370	AM1311 (infC)	1154526..1154783 [-], 258	56417284	translation initiation factor IF-3
371	AM1312 (virD4)	1154957..1157377 [-], 2421	56417285	type IV secretion system protein VirB8	VirD4
372	AM1313 (virB11)	1157425..1158438 [-], 1014	56417286	type IV secretion system ATPase VirB11	VirB11
373	AM1314 (virB10)	1158480..1159817 [-], 1338	56417287	VirB10 protein	VirB10
374	AM1315 (virB9)	1159825..1160664 [-], 840	56417288	VirB9 protein	VirB9
375	AM1316 (virB8)	1160651..1161340 [-], 690	56417289	VirB8 protein	VirB8
376	AM1317 (ribA)	1161459..1162592 [-], 1134	56417290	GTP cyclohydrolase II
377	AM1319	1162709..1163950 [-], 1242	56417291	hypothetical protein
378	AM1320	1163892..1164419 [-], 528	56417292	hypothetical protein
379	AM1323 (dapF)	1164480..1165313 [-], 834	56417293	diaminopimelate epimerase
380	AM1324	1165325..1166041 [-], 717	56417294	hypothetical protein
381	AM1325	1166183..1166611 [-], 429	56417295	hypothetical protein
382	AM1326 (pgk)	1167047..1168204 [+], 1158	56417296	phosphoglycerate kinase
383	AM1327 (xseA)	1168396..1169589 [-], 1194	56417297	exodeoxyribonuclease large subunit
384	AM1328	1169564..1170232 [-], 669	56417298	hypothetical protein
385	AM1331 (dapD)	1170411..1171247 [+], 837	161544976	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase
386	AM1332 (trmE)	1171248..1172579 [+], 1332	56417300	tRNA modification GTPase TrmE
387	AM1335 (dfp)	1172736..1173293 [-], 558	56417301	phosphopantothenoylcysteine decarboxylase
388	AM1336 (recG)	1173303..1175402 [+], 2100	56417302	ATP-dependent DNA helicase
389	AM1337	1175585..1176565 [+], 981	56417303	hypothetical protein
390	AM1338 (purF)	1176700..1178109 [-], 1410	56417304	amidophosphoribosyltransferase
391	AM1339 (pth)	1178260..1178820 [-], 561	56417305	peptidyl-tRNA hydrolase
392	AM1340 (rplY)	1178825..1179481 [-], 657	56417306	50S ribosomal protein L25/general stress protein Ctc
393	AM1341	1179523..1179741 [-], 219	56417307	hypothetical protein
394	AM1346	1183255..1184004 [-], 750	56417308	hypothetical protein
395	AM1347 (dapE)	1183943..1185145 [-], 1203	56417309	succinyl-diaminopimelate desuccinylase
396	AM1348 (kefB)	1185315..1187006 [-], 1692	56417310	glutathione-regulated potassium-efflux system protein
397	AM1349	1187020..1187583 [-], 564	56417311	hypothetical protein
398	AM1350	1187811..1188257 [-], 447	56417312	hypothetical protein
399	AM1351 (pdhB)	1188388..1189413 [-], 1026	56417313	pyruvate dehydrogenase subunit beta
400	AM1352	1189478..1192339 [-], 2862	56417314	hypothetical protein
401	AM1353 (tldD)	1192852..1194273 [+], 1422	56417315	tldD protein
402	AM1354	1194357..1194593 [-], 237	56417316	hypothetical protein
403	AM1355	1194703..1195797 [-], 1095	56417317	GTP-dependent nucleic acid-binding protein EngD
404	AM1356 (ispF)	1195978..1196568 [-], 591	56417318	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
405	AM1357 (ispD)	1196596..1197306 [-], 711	56417319	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
406	AM1359	1..1905 [+], 1905	56416371	hypothetical protein
407	AM001 (purE)	1862..2362 [-], 501	56416372	phosphoribosylaminoimidazole carboxylase catalytic subunit
408	AM002	2355..2957 [-], 603	56416373	hypothetical protein
409	AM005 (rodA)	3113..4183 [+], 1071	56416374	rod shape determining protein
410	AM006	4258..4554 [+], 297	56416375	hypothetical protein
411	AM007	4551..4925 [+], 375	56416376	hypothetical protein
412	AM008	5187..6119 [-], 933	56416377	hypothetical protein
413	AM009	6209..6619 [-], 411	56416378	hypothetical protein
414	AM010 (murC)	6921..7544 [+], 624	56416379	UDP-N-acetylmuramate-alanine ligase
415	AM011 (murC)	7532..8368 [+], 837	56416380	UDP-N-acetylmuramate-alanine ligase
416	AM012 (trpS)	8395..9384 [-], 990	56416381	tryptophanyl-tRNA synthetase
417	AM013 (grpE)	9381..9875 [-], 495	56416382	GRPE protein
418	AM015 (ribD)	10097..11212 [+], 1116	56416383	riboflavin biosynthesis protein
419	AM018 (pyrG)	11486..13168 [-], 1683	56416384	CTP synthetase
420	AM019 (secG)	13181..13510 [-], 330	56416385	preprotein translocase subunit SecG
421	AM020	13686..13946 [+], 261	56416386	hypothetical protein
422	AM021 (xerD)	13939..14877 [+], 939	56416387	integrase/recombinase
423	AM023 (phnL)	15075..15749 [-], 675	56416388	ATP transporter ATP-binding protein
424	AM024 (maeB)	16020..18272 [+], 2253	56416389	malic enzyme
425	AM025	18446..21166 [+], 2721	56416390	hypothetical protein
426	AM026	21386..22900 [+], 1515	56416391	monovalent cation/H+ antiporter subunit D
427	AM027	22915..23301 [-], 387	56416392	hypothetical protein
428	AM030 (orfX)	23496..23882 [-], 387	56416393	hypothetical protein	VirB2
429	AM032 (orfY)	23955..24188 [-], 234	56416394	hypothetical protein	VirB2
430	AM034	25004..27445 [-], 2442	56416395	hypothetical protein
431	AM035	27643..27852 [+], 210	56416396	hypothetical protein
432	AM037 (thiG)	27915..28709 [+], 795	56416397	thiazole synthase
433	AM038	28807..29247 [-], 441	56416398	hypothetical protein
434	AM039 (gltX)	29429..30754 [+], 1326	56416399	glutamyl-tRNA synthetase
435	AM041	31186..32391 [+], 1206	56416400	hypothetical protein
436	AM042	32410..32967 [+], 558	56416401	hypothetical protein
437	AM044 (orfX)	33143..33541 [-], 399	56416402	hypothetical protein	VirB2
438	AM046 (orfY)	33614..33847 [-], 234	56416403	hypothetical protein	VirB2
439	AM051 (rho)	36761..38125 [-], 1365	56416404	transcription termination factor Rho
440	AM052	38234..38851 [-], 618	56416405	hypothetical protein
441	AM053 (rpmI)	39269..39469 [+], 201	56416406	50S ribosomal protein L35
442	AM054 (rplT)	39496..39882 [+], 387	56416407	50S ribosomal protein L20
443	AM055 (pheS)	39845..40900 [+], 1056	56416408	phenylalanyl-tRNA synthetase subunit alpha
444	AM056	40991..41749 [+], 759	56416409	hypothetical protein
445	AM058 (glmU)	41930..43216 [+], 1287	56416410	UDP-N-acetylglucosamine pyrophosphorylase
446	AM059 (rpsP)	43369..43638 [-], 270	56416411	30S ribosomal protein S16
447	AM060 (proP1)	43929..45215 [+], 1287	56416412	proline/betaine transport protein
448	AM063 (orfY)	47834..48067 [+], 234	56416413	hypothetical protein	VirB2
449	AM065 (orfX)	48140..48535 [+], 396	56416414	hypothetical protein	VirB2
450	AM069 (fpbA)	49429..50469 [+], 1041	56416415	iron binding protein FbpA precursor
451	AM070	50470..50649 [+], 180	56416416	hypothetical protein
452	AM071	50899..54888 [-], 3990	56416417	hypothetical protein
453	AM072	55153..61272 [+], 6120	56416418	hypothetical protein
454	AM073 (nrdR)	61443..61898 [-], 456	56416419	NrdR family transcriptional regulator
455	AM074	62431..62886 [+], 456	56416420	hypothetical protein
456	AM075 (omp14)	63055..64269 [+], 1215	56416421	outer membrane protein 14
457	AM077 (orfX)	64841..65242 [-], 402	56416422	hypothetical protein	VirB2
458	AM082 (orfX)	67571..67978 [+], 408	56416423	hypothetical protein	VirB2
459	AM085 (recA)	68810..69889 [+], 1080	56416424	recombinase A
460	AM087 (pyrE)	69984..70586 [+], 603	56416425	orotate phosphoribosyltransferase
461	AM088 (thiF)	70620..71426 [+], 807	56416426	thiamine biosynthesis protein
462	AM090 (msp4)	71782..72630 [-], 849	56416427	major surface protein 4
463	AM092	75388..76326 [-], 939	56416428	hypothetical protein
464	AM093	76411..76731 [-], 321	56416429	hypothetical protein
465	AM094	76781..76984 [+], 204	56416430	hypothetical protein
466	AM096 (trxA)	77419..77766 [-], 348	56416431	thioredoxin
467	AM097 (trbG)	77775..78587 [-], 813	56416432	conjugal transfer protein trbG precursor	VirB9
468	AM101 (pdhA)	78838..79956 [-], 1119	56416433	pyruvate dehydrogenase E1 component, subunit alpha precursor

Region 7: 900783..901468

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM982	895993..896646 [-], 654	56417056	hypothetical protein
2	AM983 (purM)	896760..897815 [+], 1056	56417057	phosphoribosylaminoimidazole synthetase
3	AM984 (xerC)	897807..898757 [-], 951	56417058	integrase/recombinase ripx
4	AM985 (gpsA)	898926..900095 [+], 1170	56417059	gylcerol-3-phosphate dehydrogenase
5	AM987 (omp15)	900092..900547 [+], 456	56417060	outer membrane protein 15
6	AM989 (orfX)	900783..901157 [-], 375	56417061	hypothetical protein	VirB2
7	AM990 (orfY)	901157..901468 [-], 312	56417062	hypothetical protein	VirB2
8	AM992 (rho)	901852..903234 [-], 1383	56417063	transcription termination factor Rho
9	AM997	903504..903842 [-], 339	56417064	hypothetical protein
10	AM998 (hslV)	904024..904593 [+], 570	56417065	ATP-dependent protease peptidase subunit
11	AM999 (hslU)	904590..906038 [+], 1449	56417066	ATP-dependent protease ATP-binding subunit HslU

Region 8: 956209..963028

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM1053 (virB4)	956209..958638 [-], 2430	56417100	VirB4 protein	VirB4
2	AM1054	958771..959145 [-], 375	56417101	hypothetical protein	VirB2
3	AM1055	959418..959795 [-], 378	56417102	hypothetical protein	VirB2
4	AM1056	960582..961172 [-], 591	56417103	hypothetical protein	VirB2
5	AM1057	961182..961730 [-], 549	56417104	hypothetical protein
6	AM1058	961959..962324 [+], 366	56417105	hypothetical protein
7	AM1059 (orfY)	962297..962566 [+], 270	56417106	hypothetical protein	VirB2
8	AM1061 (orfX)	962633..963028 [+], 396	56417107	hypothetical protein	VirB2
9	AM1063 (msp3)	963365..966196 [+], 2832	56417108	major surface protein 3
10	AM1064 (hflK)	966443..967555 [+], 1113	56417109	hflK protein

Region 9: 1034507..1034896

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM1142 (opag2)	1029680..1030591 [+], 912	56417169	msp2 operon associated gene 2
2	AM1143 (opag1)	1030615..1031007 [+], 393	56417170	msp2 operon associated gene 1
3	AM1144 (msp2)	1031020..1032243 [+], 1224	56417171	major surface protein 2
4	AM1145	1032455..1032949 [-], 495	56417172	hypothetical protein
5	AM1146	1032906..1033490 [+], 585	56417173	hypothetical protein
6	AM1149 (orfX)	1034507..1034896 [-], 390	56417174	hypothetical protein	VirB2
7	AM1156 (omp2)	1038392..1039126 [-], 735	56417175	outer membrane protein 2
8	AM1159 (omp3)	1039207..1039857 [-], 651	56417176	outer membrane protein 3

Region 10: 1113315..1114010

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM1245 (secD)	1108831..1110336 [+], 1506	56417239	preprotein translocase subunit SecD
2	AM1248	1110826..1112649 [+], 1824	56417240	hypothetical protein
3	AM1251 (orfY)	1113315..1113548 [+], 234	56417241	hypothetical protein	VirB2
4	AM1253 (orfX)	1113621..1114010 [+], 390	56417242	hypothetical protein	VirB2
5	AM1254	1114075..1115559 [-], 1485	56417243	hypothetical protein
6	AM1255 (omp11)	1115669..1116658 [-], 990	56417244	outer membrane protein 11
7	AM1257 (omp12)	1116852..1117709 [-], 858	56417245	outer membrane protein 12
8	AM1258 (omp13)	1117917..1118975 [-], 1059	56417246	outer membrane protein 13

Region 11: 1154957..1161340

#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	AM1306	1151233..1152033 [+], 801	56417280	hypothetical protein
2	AM1307 (nadA)	1152053..1153009 [+], 957	56417281	quinolinate synthetase
3	AM1309 (fdxA)	1153031..1153402 [-], 372	56417282	ferredoxin II
4	AM1310 (ilvC)	1153528..1154499 [+], 972	56417283	ketol-acid reductoisomerase
5	AM1311 (infC)	1154526..1154783 [-], 258	56417284	translation initiation factor IF-3
6	AM1312 (virD4)	1154957..1157377 [-], 2421	56417285	type IV secretion system protein VirB8	VirD4
7	AM1313 (virB11)	1157425..1158438 [-], 1014	56417286	type IV secretion system ATPase VirB11	VirB11
8	AM1314 (virB10)	1158480..1159817 [-], 1338	56417287	VirB10 protein	VirB10
9	AM1315 (virB9)	1159825..1160664 [-], 840	56417288	VirB9 protein	VirB9
10	AM1316 (virB8)	1160651..1161340 [-], 690	56417289	VirB8 protein	VirB8
11	AM1317 (ribA)	1161459..1162592 [-], 1134	56417290	GTP cyclohydrolase II
12	AM1319	1162709..1163950 [-], 1242	56417291	hypothetical protein
13	AM1320	1163892..1164419 [-], 528	56417292	hypothetical protein
14	AM1323 (dapF)	1164480..1165313 [-], 834	56417293	diaminopimelate epimerase
15	AM1324	1165325..1166041 [-], 717	56417294	hypothetical protein

Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files

Proteins Genes

Effectors

AM185, AM470, AnkA, AM1141

The information of protein effectors
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	*
1	AM185	157060..159456 [+], 2397	56416496	hypothetical protein	AM185
2	AM470	421771..425556 [-], 3786	56416688	hypothetical protein	AM470
3	AM705 (ankA)	640456..644619 [+], 4164	56416853	ankyrin	AnkA
4	AM1141	1028745..1029848 [-], 1104	56417168	hypothetical protein	AM1141

T4SE derived from experimental literature.

Download FASTA format files

Proteins Genes

(1) Morse K; Norimine J; Palmer GH; Sutten EL; Baszler TV; Brown WC (2012). Association and evidence for linked recognition of type IV secretion system proteins VirB9-1, VirB9-2, and VirB10 in Anaplasma marginale. Infect Immun. 80(1):215-27. [PudMed:22038917]

(2) Sutten EL; Norimine J; Beare PA; Heinzen RA; Lopez JE; Morse K; Brayton KA; Gillespie JJ; Brown WC (2010). Anaplasma marginale type IV secretion system proteins VirB2, VirB7, VirB11, and VirD4 are immunogenic components of a protective bacterial membrane vaccine. Infect Immun. 78(3):1314-25. [PudMed:20065028]

(3) Araujo FR; Costa CM; Ramos CA; Farias TA; Souza II; Melo ES; Elisei C; Rosinha GM; Soares CO; Fragoso SP; Fonseca AH (2008). IgG and IgG2 antibodies from cattle naturally infected with Anaplasma marginale recognize the recombinant vaccine candidate antigens VirB9, VirB10, and elongation factor-Tu. Mem Inst Oswaldo Cruz. 103(2):186-90. [PudMed:18425271]

(4) Lopez JE; Palmer GH; Brayton KA; Dark MJ; Leach SE; Brown WC (2007). Immunogenicity of Anaplasma marginale type IV secretion system proteins in a protective outer membrane vaccine. Infect Immun. 75(5):2333-42. [PudMed:17339347]

(5) Lopez JE; Siems WF; Palmer GH; Brayton KA; McGuire TC; Norimine J; Brown WC (2005). Identification of novel antigenic proteins in a complex Anaplasma marginale outer membrane immunogen by mass spectrometry and genomic mapping. Infect Immun. 73(12):8109-18. [PudMed:16299305]

(6) Brayton KA; Kappmeyer LS; Herndon DR; Dark MJ; Tibbals DL; Palmer GH; McGuire TC; Knowles DP Jr (2005). Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins. Proc Natl Acad Sci U S A. 102(3):844-9. [PudMed:15618402]

This literature contains experimental investigation