Detailed information NTG0095479

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: QMM27_RS10315
• Genome accession: NZ_AP025939
• Coordinates: 2028143..2028895 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain Utah_35B-24
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2023143..2033895

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QMM27_RS10295	-	2025619..2027230 (-)	1612	Protein_2000	YhgE/Pip domain-containing protein	-
QMM27_RS10300 (Utah35B_19990)	-	2027358..2027900 (+)	543	WP_001158263.1	TetR/AcrR family transcriptional regulator	-
QMM27_RS10315 (Utah35B_20000)	comE	2028143..2028895 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
QMM27_RS10320 (Utah35B_20010)	comD/comD2	2028892..2030217 (-)	1326	WP_001842237.1	competence system sensor histidine kinase ComD	Regulator
QMM27_RS10325	comC/comC2	2030238..2030363 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
QMM27_RS10335 (Utah35B_20020)	rlmH	2030645..2031124 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
QMM27_RS10340 (Utah35B_20030)	htrA	2031307..2032488 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
QMM27_RS10345 (Utah35B_20040)	spo0J	2032546..2033304 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=95479 QMM27_RS10315 WP_000866065.1 2028143..2028895(-) (comE) [Streptococcus pneumoniae strain Utah_35B-24]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=95479 QMM27_RS10315 WP_000866065.1 2028143..2028895(-) (comE) [Streptococcus pneumoniae strain Utah_35B-24]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408