Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   QML92_RS08610 Genome accession   NZ_AP025937
Coordinates   1700765..1702021 (-) Length   418 a.a.
NCBI ID   WP_000642706.1    Uniprot ID   A0A098Z3K2
Organism   Streptococcus pneumoniae strain PZ900700792     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1692610..1733692 1700765..1702021 within 0


Gene organization within MGE regions


Location: 1692610..1733692
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QML92_RS08560 (PC0780_16860) - 1692907..1693458 (-) 552 WP_001111255.1 hypothetical protein -
  QML92_RS08565 (PC0780_16870) - 1693448..1693645 (-) 198 WP_000890144.1 hypothetical protein -
  QML92_RS08570 (PC0780_16880) - 1693649..1694443 (-) 795 WP_001101210.1 hypothetical protein -
  QML92_RS08575 (PC0780_16890) - 1694851..1695276 (-) 426 WP_000204065.1 hypothetical protein -
  QML92_RS08580 (PC0780_16900) - 1695405..1695764 (-) 360 WP_000749822.1 hypothetical protein -
  QML92_RS08585 (PC0780_16910) - 1695810..1696016 (-) 207 WP_000366091.1 hypothetical protein -
  QML92_RS08590 (PC0780_16920) - 1696003..1696176 (-) 174 WP_000289349.1 helix-turn-helix transcriptional regulator -
  QML92_RS08595 (PC0780_16930) lytA 1696535..1697491 (-) 957 WP_000405235.1 N-acetylmuramoyl-L-alanine amidase LytA -
  QML92_RS08600 (PC0780_16940) - 1697867..1699237 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  QML92_RS08605 (PC0780_16950) recA 1699544..1700710 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  QML92_RS08610 (PC0780_16960) cinA 1700765..1702021 (-) 1257 WP_000642706.1 competence/damage-inducible protein A Machinery gene
  QML92_RS08615 (PC0780_16970) - 1702106..1703122 (-) 1017 WP_000239278.1 LCP family protein -
  QML92_RS08620 (PC0780_16980) - 1703130..1703648 (-) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  QML92_RS08625 (PC0780_16990) tsaE 1703638..1704081 (-) 444 WP_000288230.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  QML92_RS08630 (PC0780_17000) comM 1704167..1704787 (-) 621 WP_000839909.1 hypothetical protein Regulator
  QML92_RS08635 (PC0780_17010) - 1705093..1705956 (-) 864 WP_001093609.1 helix-turn-helix transcriptional regulator -
  QML92_RS08640 (PC0780_17020) - 1706148..1706318 (+) 171 WP_001227863.1 PhrA family quorum-sensing system peptide -
  QML92_RS08645 (PC0780_17030) - 1706720..1707034 (+) 315 WP_000420682.1 YdcP family protein -
  QML92_RS08650 (PC0780_17040) - 1707050..1707436 (+) 387 WP_000985015.1 YdcP family protein -
  QML92_RS08655 (PC0780_17050) - 1707465..1708850 (+) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  QML92_RS08660 - 1708853..1709005 (+) 153 WP_000879507.1 hypothetical protein -
  QML92_RS08665 (PC0780_17060) mobT 1709028..1710233 (+) 1206 WP_000398284.1 MobT family relaxase -
  QML92_RS08670 (PC0780_17070) - 1710276..1710497 (+) 222 WP_001009056.1 hypothetical protein -
  QML92_RS08675 (PC0780_17080) - 1710614..1711111 (+) 498 WP_000342539.1 antirestriction protein ArdA -
  QML92_RS08680 (PC0780_17090) - 1711200..1711592 (+) 393 WP_000723888.1 conjugal transfer protein -
  QML92_RS08685 (PC0780_17100) - 1711576..1714023 (+) 2448 WP_000331160.1 ATP-binding protein -
  QML92_RS08690 (PC0780_17110) - 1714026..1716203 (+) 2178 WP_001814875.1 membrane protein -
  QML92_RS08695 (PC0780_17120) - 1716200..1717201 (+) 1002 WP_000769868.1 bifunctional lysozyme/C40 family peptidase -
  QML92_RS08700 (PC0780_17130) - 1717198..1718130 (+) 933 WP_001224318.1 conjugal transfer protein -
  QML92_RS08705 - 1718375..1718491 (+) 117 WP_001814923.1 tetracycline resistance determinant leader peptide -
  QML92_RS08710 (PC0780_17140) tet(M) 1718507..1720426 (+) 1920 WP_000691729.1 tetracycline resistance ribosomal protection protein Tet(M) -
  QML92_RS08715 (PC0780_17150) - 1720790..1721035 (+) 246 WP_001813542.1 hypothetical protein -
  QML92_RS08720 (PC0780_17160) - 1721032..1721367 (+) 336 WP_000806926.1 hypothetical protein -
  QML92_RS08725 (PC0780_17170) - 1721380..1721748 (+) 369 WP_000567222.1 hypothetical protein -
  QML92_RS08730 (PC0780_17180) - 1721735..1722034 (+) 300 WP_001072467.1 DUF5960 family protein -
  QML92_RS08735 (PC0780_17190) msr(D) 1722152..1723615 (-) 1464 WP_000420313.1 ABC-F type ribosomal protection protein Msr(D) -
  QML92_RS08740 (PC0780_17200) mef(A) 1723735..1724952 (-) 1218 WP_000417519.1 macrolide efflux MFS transporter Mef(A) -
  QML92_RS08745 (PC0780_17210) - 1725338..1725508 (-) 171 WP_000873143.1 hypothetical protein -
  QML92_RS08750 - 1726030..1726221 (+) 192 WP_001860868.1 cysteine-rich KTR domain-containing protein -
  QML92_RS08755 (PC0780_17220) - 1726281..1726634 (-) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  QML92_RS08760 (PC0780_17230) - 1727139..1727561 (+) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  QML92_RS08765 (PC0780_17240) - 1727558..1727788 (+) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  QML92_RS08770 - 1728014..1728265 (-) 252 WP_001845478.1 hypothetical protein -
  QML92_RS08775 (PC0780_17250) - 1728249..1728452 (+) 204 WP_000814511.1 excisionase -
  QML92_RS08780 (PC0780_17260) - 1728534..1729751 (+) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  QML92_RS08785 (PC0780_17270) - 1730642..1732657 (+) 2016 WP_000732395.1 DUF1430 domain-containing protein -
  QML92_RS08790 (PC0780_17280) - 1732659..1733291 (+) 633 WP_000571425.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45062.40 Da        Isoelectric Point: 4.5211

>NTDB_id=95300 QML92_RS08610 WP_000642706.1 1700765..1702021(-) (cinA) [Streptococcus pneumoniae strain PZ900700792]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=95300 QML92_RS08610 WP_000642706.1 1700765..1702021(-) (cinA) [Streptococcus pneumoniae strain PZ900700792]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A098Z3K2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae Rx1

99.761

100

0.998
  cinA Streptococcus pneumoniae R6

99.761

100

0.998
  cinA Streptococcus pneumoniae TIGR4

99.522

100

0.995
  cinA Streptococcus pneumoniae D39

99.522

100

0.995
  cinA Streptococcus mitis SK321

93.541

100

0.935
  cinA Streptococcus mitis NCTC 12261

93.301

100

0.933
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment