Detailed information NTG0924968

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: VKP56_RS00330
• Genome accession: NZ_CP142350
• Coordinates: 53364..54275 (+)
• Length: 303 a.a.
• NCBI ID: WP_011888526.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain SS1445
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48364..59275

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP56_RS00310 (VKP56_00310)	purE	48634..49125 (+)	492	WP_032464131.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
VKP56_RS00315 (VKP56_00315)	purK	49112..50185 (+)	1074	WP_168389345.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
VKP56_RS00320 (VKP56_00320)	-	50287..51768 (+)	1482	WP_009880316.1	PIN-like domain-containing protein	-
VKP56_RS00325 (VKP56_00325)	purB	51941..53233 (+)	1293	WP_115353931.1	adenylosuccinate lyase	-
VKP56_RS00330 (VKP56_00330)	comR	53364..54275 (+)	912	WP_011888526.1	helix-turn-helix domain-containing protein	Regulator
VKP56_RS00335 (VKP56_00335)	comS	54366..54464 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
VKP56_RS00340 (VKP56_00340)	ruvB	54495..55493 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
VKP56_RS00345 (VKP56_00345)	-	55631..56068 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
VKP56_RS00350 (VKP56_00350)	-	56091..56492 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
VKP56_RS00355 (VKP56_00355)	-	56489..58264 (+)	1776	WP_115353932.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35915.59 Da
• Isoelectric Point: 4.9349

>NTDB_id=924968 VKP56_RS00330 WP_011888526.1 53364..54275(+) (comR) [Streptococcus pyogenes strain SS1445]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=924968 VKP56_RS00330 WP_011888526.1 53364..54275(+) (comR) [Streptococcus pyogenes strain SS1445]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.67	100	0.997
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366