Detailed information NTG0921678

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: VRA41_RS05365
• Genome accession: NZ_CP142105
• Coordinates: 1014228..1015109 (-)
• Length: 293 a.a.
• NCBI ID: WP_011226089.1
• Uniprot ID: Q5M441
• Organism: Streptococcus thermophilus strain SCB0351
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1009228..1020109

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VRA41_RS05340 (VRA41_05340)	vicR	1009928..1010635 (-)	708	WP_011227274.1	response regulator YycF	Regulator
VRA41_RS05345 (VRA41_05345)	-	1011167..1011934 (+)	768	WP_011227275.1	amino acid ABC transporter ATP-binding protein	-
VRA41_RS05350 (VRA41_05350)	-	1011946..1012779 (+)	834	WP_011227276.1	transporter substrate-binding domain-containing protein	-
VRA41_RS05355 (VRA41_05355)	-	1012797..1013495 (+)	699	WP_011226087.1	amino acid ABC transporter permease	-
VRA41_RS05360 (VRA41_05360)	-	1013507..1014157 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
VRA41_RS05365 (VRA41_05365)	endA	1014228..1015109 (-)	882	WP_011226089.1	DNA/RNA non-specific endonuclease	Machinery gene
VRA41_RS05370 (VRA41_05370)	-	1015171..1015359 (-)	189	WP_011227277.1	DNA-directed RNA polymerase subunit beta	-
VRA41_RS05375 (VRA41_05375)	murA	1015361..1016632 (-)	1272	WP_041827046.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
VRA41_RS05380 (VRA41_05380)	-	1016702..1016938 (-)	237	WP_002946959.1	DUF1146 family protein	-
VRA41_RS05385 (VRA41_05385)	galE	1017126..1018139 (-)	1014	WP_011227279.1	UDP-glucose 4-epimerase GalE	-
VRA41_RS05390 (VRA41_05390)	-	1018154..1018609 (-)	456	WP_041827047.1	DUF4832 domain-containing protein	-

Sequence

Protein

• Length: 293 a.a.
• Molecular weight: 31757.50 Da
• Isoelectric Point: 10.1789

>NTDB_id=921678 VRA41_RS05365 WP_011226089.1 1014228..1015109(-) (endA) [Streptococcus thermophilus strain SCB0351]
MAKRKTSLTNKQKRQLVTLIIAALIAVLGYLGTSNKLSPDNPIRQVASLVAGKSNKSIKSNGSTNSQSTPQEQLAETVMT
SSVKSQLGNSLEWNGAGAYIINRNKTNLNAKVSSQPYANNQVKTVQGQTVPTVANALLSKATRQYKNRQETGNGSTSWTP
AGWHQVQNLSGEYSHAVDRGHLLGYALIGGLKGFDASTSNPENIAVQTAWANQAYSDSSTGQNYYESLVRKALDKNKRVR
YRVTLIYEGENLIPSGTHLEAKSADGSLEFNVFVPNVQEGITLDYYSGKVTVN

Nucleotide

• Length: 882 bp

>NTDB_id=921678 VRA41_RS05365 WP_011226089.1 1014228..1015109(-) (endA) [Streptococcus thermophilus strain SCB0351]
ATGGCAAAAAGAAAGACATCTTTGACAAATAAACAGAAACGTCAGTTAGTCACATTAATAATAGCAGCTTTGATAGCTGT
TTTAGGTTACCTAGGAACCAGTAACAAGCTCTCGCCTGATAATCCTATCAGACAAGTAGCAAGCCTAGTTGCAGGGAAAT
CTAACAAATCCATTAAATCTAATGGTTCAACAAATAGTCAGTCTACACCACAAGAGCAGCTTGCTGAGACAGTAATGACT
AGTTCAGTCAAAAGCCAACTGGGTAATTCCTTGGAATGGAATGGAGCTGGGGCCTACATTATTAATAGAAATAAGACGAA
TCTAAATGCTAAGGTATCAAGCCAACCCTATGCTAATAACCAAGTCAAAACGGTTCAAGGACAAACTGTTCCTACAGTTG
CTAATGCCTTATTAAGTAAAGCAACTAGACAGTACAAAAATCGTCAAGAAACAGGGAATGGTTCAACCTCTTGGACACCA
GCTGGATGGCACCAGGTTCAAAATTTATCAGGAGAGTATAGCCATGCCGTAGATAGAGGCCATTTGCTAGGTTATGCACT
GATAGGTGGTTTGAAAGGATTTGATGCCTCGACTTCAAATCCAGAGAATATTGCTGTTCAAACTGCTTGGGCAAATCAAG
CATATAGCGATAGTTCTACAGGCCAAAACTATTATGAAAGCCTAGTACGAAAAGCCCTGGATAAAAACAAACGTGTTCGT
TATCGTGTGACCCTGATTTATGAAGGAGAGAATCTCATTCCATCAGGAACACATCTTGAAGCTAAGTCAGCAGACGGCTC
ACTTGAGTTTAATGTCTTTGTTCCAAATGTACAAGAGGGAATTACACTAGATTACTATTCAGGAAAAGTAACGGTGAATT
GA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (101-266)

3D structure

• AlphaFold DB: Q5M441

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	72.803	81.57	0.594
endA	Streptococcus pneumoniae D39	72.803	81.57	0.594
endA	Streptococcus pneumoniae R6	72.803	81.57	0.594
endA	Streptococcus pneumoniae TIGR4	72.803	81.57	0.594