Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   SGW63_RS12240 Genome accession   NZ_CP138670
Coordinates   2450811..2451440 (+) Length   209 a.a.
NCBI ID   WP_000153535.1    Uniprot ID   W8TS97
Organism   Staphylococcus aureus strain DA70500     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2445811..2456440
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SGW63_RS12215 - 2446187..2447173 (-) 987 WP_031811349.1 aromatic acid exporter family protein -
  SGW63_RS12220 map 2447704..2448462 (+) 759 WP_000636144.1 type I methionyl aminopeptidase -
  SGW63_RS12225 - 2448679..2449065 (+) 387 WP_001110179.1 hypothetical protein -
  SGW63_RS12230 liaF 2449080..2449781 (+) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  SGW63_RS12235 vraS 2449778..2450821 (+) 1044 WP_001017133.1 sensor histidine kinase Regulator
  SGW63_RS12240 vraR 2450811..2451440 (+) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  SGW63_RS12245 - 2451552..2452769 (-) 1218 WP_000037079.1 YihY/virulence factor BrkB family protein -
  SGW63_RS12250 - 2453047..2453322 (-) 276 WP_000428172.1 YtxH domain-containing protein -
  SGW63_RS12255 - 2453329..2453793 (-) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  SGW63_RS12260 - 2453940..2454140 (+) 201 WP_000180463.1 DUF1128 family protein -
  SGW63_RS12265 - 2454143..2455399 (+) 1257 WP_001793428.1 aminopeptidase -
  SGW63_RS12270 - 2455488..2456018 (+) 531 WP_000184384.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23559.32 Da        Isoelectric Point: 5.3935

>NTDB_id=904476 SGW63_RS12240 WP_000153535.1 2450811..2451440(+) (vraR) [Staphylococcus aureus strain DA70500]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=904476 SGW63_RS12240 WP_000153535.1 2450811..2451440(+) (vraR) [Staphylococcus aureus strain DA70500]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAGGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB W8TS97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

100

100

1
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373