Detailed information NTG0090293

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LPC25_RS09765
• Genome accession: NZ_AP025176
• Coordinates: 1981463..1982506 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TPS5614
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1976463..1987506

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LPC25_RS09735 (TPS5614TP_18330)	-	1976884..1978140 (-)	1257	WP_075583716.1	aminopeptidase	-
LPC25_RS09740 (TPS5614TP_18340)	-	1978143..1978343 (-)	201	WP_000180460.1	DUF1128 family protein	-
LPC25_RS09745 (TPS5614TP_18350)	-	1978490..1978954 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LPC25_RS09750 (TPS5614TP_18360)	-	1978961..1979236 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
LPC25_RS09755 (TPS5614TP_18370)	-	1979514..1980731 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LPC25_RS09760 (TPS5614TP_18380)	vraR	1980844..1981473 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LPC25_RS09765 (TPS5614TP_18390)	vraS	1981463..1982506 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LPC25_RS09770 (TPS5614TP_18400)	liaF	1982503..1983204 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LPC25_RS09775 (TPS5614TP_18410)	-	1983219..1983605 (-)	387	WP_001110179.1	hypothetical protein	-
LPC25_RS09780 (TPS5614TP_18420)	map	1983822..1984580 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LPC25_RS09785 (TPS5614TP_18430)	-	1985109..1986095 (+)	987	WP_000999713.1	FUSC family protein	-
LPC25_RS09790 (TPS5614TP_18440)	-	1986526..1986939 (-)	414	WP_001670387.1	hypothetical protein	-
LPC25_RS09795	-	1986968..1987078 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=90293 LPC25_RS09765 WP_001017131.1 1981463..1982506(-) (vraS) [Staphylococcus aureus strain TPS5614]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=90293 LPC25_RS09765 WP_001017131.1 1981463..1982506(-) (vraS) [Staphylococcus aureus strain TPS5614]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1