Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   R5U36_RS08090 Genome accession   NZ_CP137472
Coordinates   1674288..1675571 (+) Length   427 a.a.
NCBI ID   WP_002324312.1    Uniprot ID   A0AB37VT26
Organism   Enterococcus faecium strain C4-1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1669288..1680571
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R5U36_RS08070 (R5U36_08070) - 1670153..1670452 (+) 300 Protein_1568 transposase -
  R5U36_RS08075 (R5U36_08075) - 1670487..1671656 (-) 1170 WP_089030402.1 IS256 family transposase -
  R5U36_RS08080 (R5U36_08080) - 1672113..1673099 (-) 987 WP_225596726.1 hypothetical protein -
  R5U36_RS08085 (R5U36_08085) rlmH 1673356..1673835 (-) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R5U36_RS08090 (R5U36_08090) htrA 1674288..1675571 (+) 1284 WP_002324312.1 S1C family serine protease Regulator
  R5U36_RS08095 (R5U36_08095) ytpR 1675629..1676234 (-) 606 WP_002317108.1 YtpR family tRNA-binding protein -
  R5U36_RS08100 (R5U36_08100) - 1676544..1677011 (-) 468 WP_002317107.1 universal stress protein -
  R5U36_RS08105 (R5U36_08105) - 1677041..1677361 (-) 321 WP_002317106.1 thioredoxin family protein -
  R5U36_RS08110 (R5U36_08110) pepA 1677653..1678732 (-) 1080 WP_002317105.1 glutamyl aminopeptidase -
  R5U36_RS08115 (R5U36_08115) - 1678931..1679284 (+) 354 WP_002317104.1 PepSY domain-containing protein -
  R5U36_RS08120 (R5U36_08120) - 1679456..1680412 (+) 957 WP_002317103.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 427 a.a.        Molecular weight: 44453.55 Da        Isoelectric Point: 4.7976

>NTDB_id=898160 R5U36_RS08090 WP_002324312.1 1674288..1675571(+) (htrA) [Enterococcus faecium strain C4-1]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTKV
KAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVNI
NAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITMV
DLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYRG
KEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1284 bp        

>NTDB_id=898160 R5U36_RS08090 WP_002324312.1 1674288..1675571(+) (htrA) [Enterococcus faecium strain C4-1]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATCACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGTCAACTATTTGGCCA
ACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTAATT
CCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGCCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAAGTC
AAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGTTGC
TTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATGCCA
ACTCTGTGACTTCGGGGATCATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAATATC
AATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGACAAGTGATCGG
GATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCCCAA
GTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATGGTT
GACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGTTAC
TAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTGATG
TTTCTTCTGGTGTAGAATTACAATCTGTCTTATATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGCGGA
AAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGTCAATCAGAGAACTCTGGTAA
CTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(123-268)

PDZ domain (PDZ_2)

(313-410)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.483

94.145

0.504
  htrA Streptococcus mutans UA159

54.177

92.506

0.501
  htrA Streptococcus pneumoniae D39

58.631

78.689

0.461
  htrA Streptococcus pneumoniae TIGR4

58.631

78.689

0.461
  htrA Streptococcus pneumoniae R6

58.631

78.689

0.461
  htrA Streptococcus pneumoniae Rx1

58.631

78.689

0.461
  htrA Streptococcus mitis NCTC 12261

57.738

78.689

0.454