Detailed information NTG0898111

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: R5U35_RS01165
• Genome accession: NZ_CP137468
• Coordinates: 233545..234828 (-)
• Length: 427 a.a.
• NCBI ID: WP_002324312.1
• Uniprot ID: A0AB37VT26
• Organism: Enterococcus faecium strain C20-2A
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	232149..233441	233545..234828	flank	104

Gene organization within MGE regions

Location: 232149..234828

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R5U35_RS01160 (R5U35_01160)	-	232149..233441 (+)	1293	WP_000122610.1	ISL3-like element IS1251 family transposase	-
R5U35_RS01165 (R5U35_01165)	htrA	233545..234828 (-)	1284	WP_002324312.1	S1C family serine protease	Regulator

Sequence

Protein

• Length: 427 a.a.
• Molecular weight: 44453.55 Da
• Isoelectric Point: 4.7976

>NTDB_id=898111 R5U35_RS01165 WP_002324312.1 233545..234828(-) (htrA) [Enterococcus faecium strain C20-2A]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTKV
KAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVNI
NAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITMV
DLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYRG
KEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide

• Length: 1284 bp

>NTDB_id=898111 R5U35_RS01165 WP_002324312.1 233545..234828(-) (htrA) [Enterococcus faecium strain C20-2A]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATCACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGTCAACTATTTGGCCA
ACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTAATT
CCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGCCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAAGTC
AAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGTTGC
TTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATGCCA
ACTCTGTGACTTCGGGGATCATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAATATC
AATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGACAAGTGATCGG
GATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCCCAA
GTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATGGTT
GACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGTTAC
TAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTGATG
TTTCTTCTGGTGTAGAATTACAATCTGTCTTATATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGCGGA
AAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGTCAATCAGAGAACTCTGGTAA
CTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (123-268)

• PDZ domain (PDZ_2) (313-410)

• Peptidase family M50 (Peptidase_M50) (12-414)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	53.483	94.145	0.504
htrA	Streptococcus mutans UA159	54.177	92.506	0.501
htrA	Streptococcus pneumoniae D39	58.631	78.689	0.461
htrA	Streptococcus pneumoniae TIGR4	58.631	78.689	0.461
htrA	Streptococcus pneumoniae R6	58.631	78.689	0.461
htrA	Streptococcus pneumoniae Rx1	58.631	78.689	0.461
htrA	Streptococcus mitis NCTC 12261	57.738	78.689	0.454