Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   R3H37_RS00690 Genome accession   NZ_CP136948
Coordinates   106824..107777 (+) Length   317 a.a.
NCBI ID   WP_002987790.1    Uniprot ID   A0A5S4TCX5
Organism   Streptococcus pyogenes strain Spyo01     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 101824..112777
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H37_RS00650 (R3H37_00650) - 102651..103016 (+) 366 WP_002986560.1 DUF1033 family protein -
  R3H37_RS00655 (R3H37_00655) comYA 103109..104047 (+) 939 WP_023079010.1 competence type IV pilus ATPase ComGA Machinery gene
  R3H37_RS00660 (R3H37_00660) comYB 103983..105017 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  R3H37_RS00665 (R3H37_00665) comYC 105019..105345 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  R3H37_RS00670 (R3H37_00670) comGD 105320..105748 (+) 429 WP_129284411.1 competence type IV pilus minor pilin ComGD -
  R3H37_RS00675 (R3H37_00675) comGE 105705..105989 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  R3H37_RS00680 (R3H37_00680) comYF 105982..106416 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  R3H37_RS00685 (R3H37_00685) comGG 106400..106726 (+) 327 WP_009880358.1 competence type IV pilus minor pilin ComGG -
  R3H37_RS00690 (R3H37_00690) comYH 106824..107777 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  R3H37_RS00695 (R3H37_00695) - 107836..109032 (+) 1197 WP_002987791.1 acetate kinase -
  R3H37_RS00700 (R3H37_00700) - 109218..109526 (+) 309 WP_030126458.1 hypothetical protein -
  R3H37_RS00705 (R3H37_00705) proC 109609..110379 (-) 771 WP_063631714.1 pyrroline-5-carboxylate reductase -
  R3H37_RS00710 (R3H37_00710) pepA 110427..111494 (-) 1068 WP_011284427.1 glutamyl aminopeptidase -
  R3H37_RS00715 (R3H37_00715) - 111959..112243 (+) 285 WP_129284412.1 DUF4651 domain-containing protein -
  R3H37_RS00720 (R3H37_00720) - 112240..112557 (+) 318 WP_002986515.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35985.08 Da        Isoelectric Point: 4.7205

>NTDB_id=893584 R3H37_RS00690 WP_002987790.1 106824..107777(+) (comYH) [Streptococcus pyogenes strain Spyo01]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=893584 R3H37_RS00690 WP_002987790.1 106824..107777(+) (comYH) [Streptococcus pyogenes strain Spyo01]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACG
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAAATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACTTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTACGCTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-288)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TCX5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

66.139

99.685

0.659
  comYH Streptococcus mutans UA140

65.823

99.685

0.656