Detailed information NTG0084767

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: K5606_RS09275
• Genome accession: NZ_AP024318
• Coordinates: 1913705..1914748 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain S36
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1908705..1919748

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K5606_RS09245 (S36TP_17390)	-	1909126..1910382 (-)	1257	WP_001793428.1	aminopeptidase	-
K5606_RS09250 (S36TP_17400)	-	1910385..1910585 (-)	201	WP_000180460.1	DUF1128 family protein	-
K5606_RS09255 (S36TP_17410)	-	1910732..1911196 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
K5606_RS09260 (S36TP_17420)	-	1911203..1911478 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
K5606_RS09265 (S36TP_17430)	-	1911756..1912973 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
K5606_RS09270 (S36TP_17440)	vraR	1913086..1913715 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
K5606_RS09275 (S36TP_17450)	vraS	1913705..1914748 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
K5606_RS09280 (S36TP_17460)	liaF	1914745..1915446 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
K5606_RS09285 (S36TP_17470)	-	1915461..1915847 (-)	387	WP_001110182.1	hypothetical protein	-
K5606_RS09290 (S36TP_17480)	map	1916064..1916822 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
K5606_RS09295 (S36TP_17490)	-	1917406..1918392 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
K5606_RS09300 (S36TP_17500)	-	1918581..1918994 (-)	414	WP_025174370.1	hypothetical protein	-
K5606_RS09305	-	1919023..1919133 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=84767 K5606_RS09275 WP_001017131.1 1913705..1914748(-) (vraS) [Staphylococcus aureus strain S36]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=84767 K5606_RS09275 WP_001017131.1 1913705..1914748(-) (vraS) [Staphylococcus aureus strain S36]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1