Detailed information NTG0847130

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QTN90_RS11470
• Genome accession: NZ_CP128387
• Coordinates: 2382772..2383815 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 22-042
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2377772..2388815

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QTN90_RS11440 (QTN90_11440)	-	2378387..2378497 (+)	111	WP_014937049.1	hypothetical protein	-
QTN90_RS11445 (QTN90_11445)	-	2378526..2378939 (+)	414	WP_025174370.1	hypothetical protein	-
QTN90_RS11450 (QTN90_11450)	-	2379128..2380114 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
QTN90_RS11455 (QTN90_11455)	map	2380698..2381456 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
QTN90_RS11460 (QTN90_11460)	-	2381673..2382059 (+)	387	WP_001110182.1	hypothetical protein	-
QTN90_RS11465 (QTN90_11465)	liaF	2382074..2382775 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QTN90_RS11470 (QTN90_11470)	vraS	2382772..2383815 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QTN90_RS11475 (QTN90_11475)	vraR	2383805..2384434 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QTN90_RS11480 (QTN90_11480)	-	2384547..2385764 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
QTN90_RS11485 (QTN90_11485)	-	2386042..2386317 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QTN90_RS11490 (QTN90_11490)	-	2386324..2386788 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QTN90_RS11495 (QTN90_11495)	-	2386935..2387135 (+)	201	WP_000180460.1	DUF1128 family protein	-
QTN90_RS11500 (QTN90_11500)	-	2387138..2388394 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=847130 QTN90_RS11470 WP_001017131.1 2382772..2383815(+) (vraS) [Staphylococcus aureus strain 22-042]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=847130 QTN90_RS11470 WP_001017131.1 2382772..2383815(+) (vraS) [Staphylococcus aureus strain 22-042]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1