Detailed information NTG0812403

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QA589_RS00595
• Genome accession: NZ_CP121480
• Coordinates: 115292..116338 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 47FSE01
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 110292..121338

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QA589_RS00570	-	111434..111970 (+)	537	WP_001830372.1	hypothetical protein	-
QA589_RS00575	-	112120..113106 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
QA589_RS00580	map	113280..114035 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
QA589_RS00585	-	114193..114579 (+)	387	WP_001830382.1	hypothetical protein	-
QA589_RS00590	liaF	114594..115295 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
QA589_RS00595	vraS	115292..116338 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
QA589_RS00600	vraR	116328..116957 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
QA589_RS00605	-	117014..118192 (-)	1179	WP_049376906.1	YihY/virulence factor BrkB family protein	-
QA589_RS00610	-	118620..118904 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
QA589_RS00615	-	118912..119376 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
QA589_RS00620	-	119517..119732 (+)	216	WP_070501292.1	DUF1128 domain-containing protein	-
QA589_RS00625	-	119734..120975 (+)	1242	WP_002503582.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=812403 QA589_RS00595 WP_001830374.1 115292..116338(+) (vraS) [Staphylococcus epidermidis strain 47FSE01]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=812403 QA589_RS00595 WP_001830374.1 115292..116338(+) (vraS) [Staphylococcus epidermidis strain 47FSE01]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGGCCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92