Detailed information NTG0800045

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: P1Y72_RS03305
• Genome accession: NZ_CP119599
• Coordinates: 704780..705817 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1133
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 699780..710817

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P1Y72_RS03280 (P1Y72_03280)	-	699784..700311 (-)	528	WP_002983837.1	Dps family protein	-
P1Y72_RS03285 (P1Y72_03285)	-	700539..701165 (+)	627	WP_002983834.1	A24 family peptidase	-
P1Y72_RS03290 (P1Y72_03290)	rlmN	701247..702326 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
P1Y72_RS03295 (P1Y72_03295)	-	702330..702950 (-)	621	WP_002992791.1	YutD family protein	-
P1Y72_RS03300 (P1Y72_03300)	-	703398..704375 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
P1Y72_RS03305 (P1Y72_03305)	sepM	704780..705817 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
P1Y72_RS03310 (P1Y72_03310)	coaD	705804..706295 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
P1Y72_RS03315 (P1Y72_03315)	rsmD	706285..706824 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
P1Y72_RS03320 (P1Y72_03320)	asnA	706947..707939 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
P1Y72_RS03325 (P1Y72_03325)	arcC	708252..709202 (-)	951	WP_009880962.1	carbamate kinase	-
P1Y72_RS03330 (P1Y72_03330)	-	709222..710553 (-)	1332	WP_136273999.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=800045 P1Y72_RS03305 WP_010922499.1 704780..705817(-) (sepM) [Streptococcus pyogenes strain 1133]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=800045 P1Y72_RS03305 WP_010922499.1 704780..705817(-) (sepM) [Streptococcus pyogenes strain 1133]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693