Detailed information NTG0662353

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MNU55_RS04665
• Genome accession: NZ_CP093196
• Coordinates: 982137..983183 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain TMDU-2014-62
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 977137..988183

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MNU55_RS04640 (MNU55_04640)	-	978278..978814 (+)	537	WP_002470337.1	hypothetical protein	-
MNU55_RS04645 (MNU55_04645)	-	978965..979951 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
MNU55_RS04650 (MNU55_04650)	map	980125..980880 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MNU55_RS04655 (MNU55_04655)	-	981038..981424 (+)	387	WP_001830382.1	hypothetical protein	-
MNU55_RS04660 (MNU55_04660)	liaF	981439..982140 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
MNU55_RS04665 (MNU55_04665)	vraS	982137..983183 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MNU55_RS04670 (MNU55_04670)	vraR	983173..983802 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MNU55_RS04675 (MNU55_04675)	-	983859..985037 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MNU55_RS04680 (MNU55_04680)	-	985444..985728 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MNU55_RS04685 (MNU55_04685)	-	985736..986200 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MNU55_RS04690 (MNU55_04690)	-	986341..986556 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MNU55_RS04695 (MNU55_04695)	-	986558..987799 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662353 MNU55_RS04665 WP_001830374.1 982137..983183(+) (vraS) [Staphylococcus epidermidis strain TMDU-2014-62]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662353 MNU55_RS04665 WP_001830374.1 982137..983183(+) (vraS) [Staphylococcus epidermidis strain TMDU-2014-62]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92