Detailed information NTG0646990

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KB232_RS04500
• Genome accession: NZ_CP090989
• Coordinates: 965342..966388 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 52B
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 960342..971388

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KB232_RS04475 (KB232_04475)	isaB	961484..962020 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
KB232_RS04480 (KB232_04480)	-	962170..963156 (-)	987	WP_002457091.1	FUSC family protein	-
KB232_RS04485 (KB232_04485)	map	963330..964085 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
KB232_RS04490 (KB232_04490)	-	964243..964629 (+)	387	WP_001830382.1	hypothetical protein	-
KB232_RS04495 (KB232_04495)	liaF	964644..965345 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
KB232_RS04500 (KB232_04500)	vraS	965342..966388 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KB232_RS04505 (KB232_04505)	vraR	966378..967007 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KB232_RS04510 (KB232_04510)	-	967064..968242 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
KB232_RS04515 (KB232_04515)	-	968649..968933 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
KB232_RS04520 (KB232_04520)	-	968941..969405 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KB232_RS04525 (KB232_04525)	-	969546..969761 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
KB232_RS04530 (KB232_04530)	-	969763..971004 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=646990 KB232_RS04500 WP_001830374.1 965342..966388(+) (vraS) [Staphylococcus epidermidis strain 52B]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=646990 KB232_RS04500 WP_001830374.1 965342..966388(+) (vraS) [Staphylococcus epidermidis strain 52B]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92