Detailed information NTG0590109

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: KZB15_RS04200
• Genome accession: NZ_CP079922
• Coordinates: 851970..854210 (+)
• Length: 746 a.a.
• NCBI ID: WP_000942407.1
• Uniprot ID: A0A2U3RZI0
• Organism: Streptococcus pneumoniae strain R36A
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 846970..859210

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KZB15_RS04155 (KZB15_04165)	-	847120..848088 (+)	969	WP_000658183.1	PhoH family protein	-
KZB15_RS04165 (KZB15_04175)	-	848281..848781 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
KZB15_RS04170 (KZB15_04180)	-	848784..849110 (+)	327	Protein_844	TfoX/Sxy family protein	-
KZB15_RS10530	ald	849411..850522 (-)	1112	Protein_845	alanine dehydrogenase	-
KZB15_RS04190 (KZB15_04200)	-	850699..851268 (+)	570	WP_000443899.1	GNAT family N-acetyltransferase	-
KZB15_RS04195 (KZB15_04205)	comEA/celA/cilE	851336..851986 (+)	651	WP_000387330.1	ComEA family DNA-binding protein	Machinery gene
KZB15_RS04200 (KZB15_04210)	comEC/celB	851970..854210 (+)	2241	WP_000942407.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
KZB15_RS04205 (KZB15_04215)	-	854389..854577 (+)	189	WP_010976492.1	hypothetical protein	-
KZB15_RS04210 (KZB15_04220)	-	854609..855196 (+)	588	Protein_850	ATP-binding cassette domain-containing protein	-
KZB15_RS04215 (KZB15_04225)	-	855200..856381 (+)	1182	WP_000655958.1	ABC transporter permease	-
KZB15_RS04220 (KZB15_04230)	infC	856688..857218 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
KZB15_RS04225 (KZB15_04235)	rpmI	857251..857451 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
KZB15_RS04230 (KZB15_04240)	rplT	857503..857862 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
KZB15_RS04235 (KZB15_04245)	-	857920..858300 (+)	381	WP_000157154.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84619.29 Da
• Isoelectric Point: 9.6173

>NTDB_id=590109 KZB15_RS04200 WP_000942407.1 851970..854210(+) (comEC/celB) [Streptococcus pneumoniae strain R36A]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTVKVNGDSLSFRGKADGRIFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFFTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNTWLLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIKKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEMTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMIVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPYQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=590109 KZB15_RS04200 WP_000942407.1 851970..854210(+) (comEC/celB) [Streptococcus pneumoniae strain R36A]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCCTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTCTGCCTGACACTGTTAAGGTCAATGGTGATAGTCTGTCCTTTCGCGGCAA
GGCTGATGGACGCATTTTTCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTTACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGACAAGTAGACCTCTGGTCTTTGGACAACCCAATACATGGCTTTTAATCCTATTGTTAATTTCTTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCAAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAAGCTTGATACCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGATGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGATAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCTATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (31-177)

3D structure

• AlphaFold DB: A0A2U3RZI0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae Rx1	100	100	1
comEC/celB	Streptococcus pneumoniae D39	100	100	1
comEC/celB	Streptococcus pneumoniae R6	100	100	1
comEC/celB	Streptococcus pneumoniae TIGR4	97.587	100	0.976
comEC/celB	Streptococcus mitis SK321	91.823	100	0.918
comEC/celB	Streptococcus mitis NCTC 12261	91.544	99.866	0.914
comEC	Lactococcus lactis subsp. cremoris KW2	43.725	99.33	0.434