Detailed information NTG0585593

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU496_RS10160
• Genome accession: NZ_CP077936
• Coordinates: 2044455..2045498 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 319
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2039455..2050498

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU496_RS10130 (KU496_10050)	-	2039876..2041132 (-)	1257	WP_001793983.1	aminopeptidase	-
KU496_RS10135 (KU496_10055)	-	2041135..2041335 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU496_RS10140 (KU496_10060)	-	2041482..2041946 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
KU496_RS10145 (KU496_10065)	-	2041953..2042228 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU496_RS10150 (KU496_10070)	-	2042506..2043723 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
KU496_RS10155 (KU496_10075)	vraR	2043836..2044465 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU496_RS10160 (KU496_10080)	vraS	2044455..2045498 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU496_RS10165 (KU496_10085)	liaF	2045495..2046196 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU496_RS10170 (KU496_10090)	-	2046211..2046597 (-)	387	WP_001110178.1	hypothetical protein	-
KU496_RS10175 (KU496_10095)	map	2046814..2047572 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU496_RS10180 (KU496_10100)	-	2048272..2049258 (+)	987	WP_001014423.1	FUSC family protein	-
KU496_RS10185 (KU496_10105)	-	2049447..2049860 (-)	414	WP_001643743.1	hypothetical protein	-
KU496_RS10190 (KU496_10110)	-	2049889..2049999 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585593 KU496_RS10160 WP_001017131.1 2044455..2045498(-) (vraS) [Staphylococcus aureus strain 319]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585593 KU496_RS10160 WP_001017131.1 2044455..2045498(-) (vraS) [Staphylococcus aureus strain 319]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1