Detailed information NTG0503465

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI23_RS08330
• Genome accession: NZ_CP064603
• Coordinates: 1674134..1675180 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG350
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1669134..1680180

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI23_RS08300 (HWI23_08210)	-	1669518..1670759 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI23_RS08305 (HWI23_08215)	-	1670761..1670976 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI23_RS08310 (HWI23_08220)	-	1671117..1671581 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI23_RS08315 (HWI23_08225)	-	1671589..1671873 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI23_RS08320 (HWI23_08230)	-	1672280..1673458 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI23_RS08325 (HWI23_08235)	vraR	1673515..1674144 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI23_RS08330 (HWI23_08240)	vraS	1674134..1675180 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI23_RS08335 (HWI23_08245)	liaF	1675177..1675878 (-)	702	WP_063964223.1	cell wall-active antibiotics response protein LiaF	-
HWI23_RS08340 (HWI23_08250)	-	1675893..1676279 (-)	387	WP_001830382.1	hypothetical protein	-
HWI23_RS08345 (HWI23_08255)	map	1676437..1677192 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI23_RS08350 (HWI23_08260)	-	1677366..1678352 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI23_RS08355 (HWI23_08265)	isaB	1678503..1679039 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=503465 HWI23_RS08330 WP_001830374.1 1674134..1675180(-) (vraS) [Staphylococcus epidermidis strain UMCG350]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=503465 HWI23_RS08330 WP_001830374.1 1674134..1675180(-) (vraS) [Staphylococcus epidermidis strain UMCG350]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92