Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | HWI24_RS03390 | Genome accession | NZ_CP064599 |
| Coordinates | 690199..690774 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG351 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 691175..733753 | 690199..690774 | flank | 401 |
Gene organization within MGE regions
Location: 690199..733753
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI24_RS03390 (HWI24_03350) | comK/comK1 | 690199..690774 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| HWI24_RS03405 (HWI24_03365) | - | 691175..692224 (-) | 1050 | WP_002504795.1 | site-specific integrase | - |
| HWI24_RS03410 (HWI24_03370) | - | 692335..692532 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| HWI24_RS03415 (HWI24_03375) | - | 692529..692936 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| HWI24_RS03420 (HWI24_03380) | - | 692930..693367 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| HWI24_RS03425 (HWI24_03385) | - | 693479..694147 (-) | 669 | WP_002504794.1 | hypothetical protein | - |
| HWI24_RS03430 (HWI24_03390) | - | 694165..694623 (-) | 459 | WP_002504200.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HWI24_RS03435 (HWI24_03395) | - | 694645..694959 (-) | 315 | WP_002504199.1 | helix-turn-helix transcriptional regulator | - |
| HWI24_RS03440 (HWI24_03400) | - | 695112..695324 (+) | 213 | WP_002456362.1 | helix-turn-helix transcriptional regulator | - |
| HWI24_RS03445 (HWI24_03405) | - | 695368..695508 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| HWI24_RS03450 (HWI24_03410) | - | 695501..695725 (-) | 225 | WP_002504198.1 | hypothetical protein | - |
| HWI24_RS03455 (HWI24_03415) | - | 695775..696515 (+) | 741 | WP_002504197.1 | phage repressor protein | - |
| HWI24_RS03460 (HWI24_03420) | - | 696528..696737 (+) | 210 | WP_001830281.1 | hypothetical protein | - |
| HWI24_RS03465 (HWI24_03425) | - | 696751..696897 (+) | 147 | WP_002504793.1 | hypothetical protein | - |
| HWI24_RS03470 (HWI24_03430) | - | 696884..697162 (-) | 279 | WP_002484728.1 | hypothetical protein | - |
| HWI24_RS03475 (HWI24_03435) | - | 697257..697433 (+) | 177 | WP_002484719.1 | hypothetical protein | - |
| HWI24_RS03480 (HWI24_03440) | - | 697495..697746 (+) | 252 | WP_002484751.1 | hypothetical protein | - |
| HWI24_RS03485 (HWI24_03445) | - | 697739..698224 (+) | 486 | WP_002484734.1 | siphovirus Gp157 family protein | - |
| HWI24_RS03490 (HWI24_03450) | - | 698225..698851 (+) | 627 | WP_002469464.1 | DUF1071 domain-containing protein | - |
| HWI24_RS03495 (HWI24_03455) | - | 698844..699260 (+) | 417 | WP_002484754.1 | single-stranded DNA-binding protein | - |
| HWI24_RS03500 (HWI24_03460) | - | 699274..699963 (+) | 690 | WP_002504792.1 | putative HNHc nuclease | - |
| HWI24_RS03505 (HWI24_03465) | - | 699941..700171 (+) | 231 | WP_002504791.1 | helix-turn-helix domain-containing protein | - |
| HWI24_RS03510 (HWI24_03470) | - | 700177..700392 (+) | 216 | WP_002504790.1 | helix-turn-helix domain-containing protein | - |
| HWI24_RS03515 (HWI24_03475) | - | 700379..701107 (+) | 729 | WP_002504789.1 | DnaD domain protein | - |
| HWI24_RS03520 (HWI24_03480) | - | 701113..701466 (+) | 354 | WP_002504788.1 | hypothetical protein | - |
| HWI24_RS03525 (HWI24_03485) | - | 701456..702703 (+) | 1248 | WP_002504787.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| HWI24_RS03530 (HWI24_03490) | - | 702700..702930 (+) | 231 | WP_002504786.1 | hypothetical protein | - |
| HWI24_RS03535 (HWI24_03495) | - | 702899..703123 (+) | 225 | WP_002456377.1 | DUF3269 family protein | - |
| HWI24_RS03540 (HWI24_03500) | - | 703134..703550 (+) | 417 | WP_002504785.1 | DUF1064 domain-containing protein | - |
| HWI24_RS03545 (HWI24_03505) | - | 703537..703911 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| HWI24_RS03550 (HWI24_03510) | - | 703911..704102 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| HWI24_RS03555 (HWI24_03515) | - | 704103..704462 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| HWI24_RS03560 (HWI24_03520) | - | 704459..704911 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| HWI24_RS03565 (HWI24_03525) | - | 704901..705188 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| HWI24_RS03570 (HWI24_03530) | - | 705204..705884 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| HWI24_RS03575 (HWI24_03535) | - | 705881..706081 (+) | 201 | WP_002504783.1 | hypothetical protein | - |
| HWI24_RS03580 (HWI24_03540) | - | 706065..706418 (+) | 354 | WP_002504782.1 | hypothetical protein | - |
| HWI24_RS03585 (HWI24_03545) | - | 706399..706596 (+) | 198 | WP_002504781.1 | Lar family restriction alleviation protein | - |
| HWI24_RS03590 (HWI24_03550) | - | 706597..707124 (+) | 528 | WP_002504780.1 | dUTPase | - |
| HWI24_RS03595 (HWI24_03555) | - | 707286..707444 (+) | 159 | WP_002504779.1 | DUF1381 domain-containing protein | - |
| HWI24_RS03600 (HWI24_03560) | - | 707503..707781 (+) | 279 | WP_002504778.1 | hypothetical protein | - |
| HWI24_RS03605 (HWI24_03565) | rinB | 707774..707941 (+) | 168 | WP_002504777.1 | transcriptional activator RinB | - |
| HWI24_RS03610 (HWI24_03570) | - | 707941..708090 (+) | 150 | WP_002484731.1 | DUF1514 family protein | - |
| HWI24_RS03615 (HWI24_03575) | - | 708107..708553 (+) | 447 | WP_002484732.1 | transcriptional regulator | - |
| HWI24_RS03620 (HWI24_03580) | - | 709148..709498 (+) | 351 | WP_002504776.1 | HNH endonuclease | - |
| HWI24_RS03625 (HWI24_03585) | - | 709641..710111 (+) | 471 | WP_002484733.1 | phage terminase small subunit P27 family | - |
| HWI24_RS03630 (HWI24_03590) | - | 710104..711855 (+) | 1752 | WP_002484749.1 | terminase large subunit | - |
| HWI24_RS03635 (HWI24_03595) | - | 711867..712061 (+) | 195 | WP_002500102.1 | hypothetical protein | - |
| HWI24_RS03640 (HWI24_03600) | - | 712064..713296 (+) | 1233 | WP_002504774.1 | phage portal protein | - |
| HWI24_RS03645 (HWI24_03605) | - | 713286..713843 (+) | 558 | WP_002504773.1 | HK97 family phage prohead protease | - |
| HWI24_RS03650 (HWI24_03610) | - | 713883..715232 (+) | 1350 | WP_002504772.1 | phage major capsid protein | - |
| HWI24_RS03655 (HWI24_03615) | - | 715251..715592 (+) | 342 | WP_002484745.1 | head-tail connector protein | - |
| HWI24_RS03660 (HWI24_03620) | - | 715582..715911 (+) | 330 | WP_002484730.1 | hypothetical protein | - |
| HWI24_RS03665 (HWI24_03625) | - | 716025..716312 (+) | 288 | WP_002484720.1 | hypothetical protein | - |
| HWI24_RS03670 (HWI24_03630) | - | 716315..716719 (+) | 405 | WP_002484722.1 | hypothetical protein | - |
| HWI24_RS03675 (HWI24_03635) | - | 716732..717361 (+) | 630 | WP_002484765.1 | major tail protein | - |
| HWI24_RS03680 (HWI24_03640) | - | 717380..717565 (+) | 186 | WP_002484762.1 | hypothetical protein | - |
| HWI24_RS03685 (HWI24_03645) | gpG | 717629..717991 (+) | 363 | WP_002484709.1 | phage tail assembly chaperone G | - |
| HWI24_RS03690 (HWI24_03650) | gpGT | 718036..718176 (+) | 141 | WP_002484764.1 | phage tail assembly chaperone GT | - |
| HWI24_RS03695 (HWI24_03655) | - | 718205..722761 (+) | 4557 | Protein_714 | peptidoglycan DD-metalloendopeptidase family protein | - |
| HWI24_RS03700 (HWI24_03660) | - | 722763..723596 (+) | 834 | WP_002504770.1 | phage tail domain-containing protein | - |
| HWI24_RS03705 (HWI24_03665) | - | 723606..725165 (+) | 1560 | WP_002504769.1 | prophage endopeptidase tail family protein | - |
| HWI24_RS03710 (HWI24_03670) | - | 725158..725331 (+) | 174 | WP_002456411.1 | hypothetical protein | - |
| HWI24_RS03715 (HWI24_03675) | - | 725347..727209 (+) | 1863 | WP_002504768.1 | M14 family metallopeptidase | - |
| HWI24_RS03720 (HWI24_03680) | - | 727209..728423 (+) | 1215 | WP_002504767.1 | BppU family phage baseplate upper protein | - |
| HWI24_RS03725 (HWI24_03685) | - | 728428..729051 (+) | 624 | WP_002504766.1 | poly-gamma-glutamate hydrolase family protein | - |
| HWI24_RS03730 (HWI24_03690) | - | 729048..729473 (+) | 426 | WP_002456415.1 | hypothetical protein | - |
| HWI24_RS03735 (HWI24_03695) | - | 729460..729867 (+) | 408 | WP_002504154.1 | hypothetical protein | - |
| HWI24_RS03740 (HWI24_03700) | - | 729993..730259 (+) | 267 | WP_002504765.1 | phage holin | - |
| HWI24_RS03745 (HWI24_03705) | - | 730259..731641 (+) | 1383 | WP_002504764.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HWI24_RS03750 (HWI24_03710) | - | 731719..732645 (+) | 927 | WP_002504133.1 | hypothetical protein | - |
| HWI24_RS03755 (HWI24_03715) | - | 732838..733365 (+) | 528 | WP_002504240.1 | Panacea domain-containing protein | - |
| HWI24_RS03760 (HWI24_03720) | - | 733355..733753 (+) | 399 | WP_002504241.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=503410 HWI24_RS03390 WP_001829272.1 690199..690774(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG351]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=503410 HWI24_RS03390 WP_001829272.1 690199..690774(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG351]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |