Detailed information NTG0469852

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: H1R75_RS08865
• Genome accession: NZ_CP059471
• Coordinates: 1751295..1752026 (-)
• Length: 243 a.a.
• NCBI ID: WP_182001379.1
• Uniprot ID: -
• Organism: Streptococcus equinus strain MDC1
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1746295..1757026

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1R75_RS08835 (H1R75_08835)	comD/comD3	1747107..1748489 (-)	1383	WP_235686233.1	GHKL domain-containing protein	Regulator
H1R75_RS08840 (H1R75_08840)	-	1748490..1748687 (-)	198	WP_182001376.1	hypothetical protein	-
H1R75_RS08845 (H1R75_08845)	-	1748849..1749142 (-)	294	WP_182001377.1	bacteriocin immunity protein	-
H1R75_RS08850 (H1R75_08850)	-	1749173..1749478 (-)	306	WP_024344359.1	bacteriocin immunity protein	-
H1R75_RS08855 (H1R75_08855)	-	1749498..1749794 (-)	297	WP_182001378.1	DUF3884 family protein	-
H1R75_RS09880	comD/comD1	1749969..1750691 (-)	723	WP_235686234.1	sensor histidine kinase	Regulator
H1R75_RS09885	-	1750676..1751290 (-)	615	WP_235686235.1	hypothetical protein	-
H1R75_RS08865 (H1R75_08865)	comE/comE1	1751295..1752026 (-)	732	WP_182001379.1	response regulator transcription factor	Regulator
H1R75_RS08870 (H1R75_08870)	-	1752950..1753561 (-)	612	WP_182001380.1	thioredoxin fold domain-containing protein	-
H1R75_RS08875 (H1R75_08875)	-	1754698..1755372 (-)	675	WP_182001381.1	CPBP family intramembrane glutamic endopeptidase	-
H1R75_RS08880 (H1R75_08880)	-	1755405..1756097 (-)	693	WP_235686236.1	CPBP family intramembrane glutamic endopeptidase	-
H1R75_RS08885 (H1R75_08885)	-	1756091..1756273 (-)	183	WP_182001382.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28052.92 Da
• Isoelectric Point: 5.6824

>NTDB_id=469852 H1R75_RS08865 WP_182001379.1 1751295..1752026(-) (comE/comE1) [Streptococcus equinus strain MDC1]
MLDIFILEDNITQQFRIERQIEAIMEKNNWAYQHLEAFAASEDIIAKASEKKSHQIFFLDLEIKGDEKQGIDVARAIREK
DSTAIIVFVTTHSEFMLLTYQSLVGAIDFIDKNLNDAAFEQRLELCLKETLKYQKGNLGENSYLFETAKARIRVAYDDIL
YFETSPTVHRVILHTKTGQTEFYGTIAEVAKSDERLFKCHRSFVINVNNVAEFDKSTRTAYFANGSYCQVSRDKVKSLMA
EMR

Nucleotide

• Length: 732 bp

>NTDB_id=469852 H1R75_RS08865 WP_182001379.1 1751295..1752026(-) (comE/comE1) [Streptococcus equinus strain MDC1]
ATGTTAGATATTTTTATCCTTGAGGATAATATCACGCAACAATTTCGTATTGAGCGACAGATAGAGGCAATTATGGAAAA
GAATAATTGGGCTTATCAGCACTTGGAAGCTTTTGCGGCATCTGAGGATATTATTGCAAAAGCATCTGAAAAGAAGAGCC
ATCAGATTTTTTTTCTTGATTTAGAAATTAAAGGGGATGAAAAGCAAGGAATTGACGTGGCAAGAGCCATCCGTGAGAAG
GATTCAACAGCTATTATTGTTTTTGTAACGACTCATTCTGAGTTTATGCTTTTAACTTATCAGTCGTTGGTTGGTGCGAT
TGATTTCATTGATAAAAATTTAAATGATGCAGCTTTTGAACAACGTCTAGAGTTATGCTTGAAGGAAACTCTTAAGTATC
AAAAAGGAAATTTAGGTGAGAATTCTTACCTTTTTGAAACTGCCAAAGCGAGAATTCGTGTAGCTTACGATGATATTTTA
TATTTTGAAACATCGCCAACCGTTCACCGAGTGATTTTACACACAAAAACAGGTCAAACTGAATTTTACGGAACGATTGC
GGAGGTTGCCAAATCAGATGAGCGTCTGTTCAAATGTCACCGCTCTTTTGTGATTAATGTAAATAATGTTGCTGAATTTG
ATAAAAGTACCCGAACAGCTTATTTTGCAAATGGCTCTTACTGCCAAGTCTCACGAGACAAAGTCAAAAGCCTAATGGCA
GAAATGAGGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-240)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	87.654	100	0.877
comE/comE2	Streptococcus equinus JB1	47.934	99.588	0.477
comE/blpR	Streptococcus mutans UA159	46.058	99.177	0.457
comE/comE2	Streptococcus gordonii strain NCTC7865	36.145	100	0.37
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	36.145	100	0.37