Detailed information NTG0442958

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: HLG73_RS12380
• Genome accession: NZ_CP053093
• Coordinates: 2513534..2515726 (-)
• Length: 730 a.a.
• NCBI ID: WP_273634362.1
• Uniprot ID: -
• Organism: Lacticaseibacillus paracasei strain CLP-Y5
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2508534..2520726

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HLG73_RS12350 (HLG73_12500)	-	2508700..2508984 (-)	285	WP_003580845.1	bacteriocin immunity protein	-
HLG73_RS12355 (HLG73_12505)	-	2509177..2509473 (-)	297	WP_003588783.1	bacteriocin immunity protein	-
HLG73_RS12360 (HLG73_12510)	-	2509575..2510930 (-)	1356	WP_003567335.1	threonine/serine ThrE exporter family protein	-
HLG73_RS12365 (HLG73_12515)	-	2511236..2511547 (-)	312	WP_003580849.1	hypothetical protein	-
HLG73_RS12370 (HLG73_12520)	-	2511620..2511970 (-)	351	WP_003567340.1	hypothetical protein	-
HLG73_RS12375 (HLG73_12525)	-	2512144..2513523 (-)	1380	WP_273634361.1	bacteriocin secretion accessory protein	-
HLG73_RS12380 (HLG73_12530)	comA	2513534..2515726 (-)	2193	WP_273634362.1	peptide cleavage/export ABC transporter	Regulator
HLG73_RS12385 (HLG73_12535)	-	2516193..2516330 (-)	138	WP_012491943.1	bacteriocin-like peptide, LSEI_2386 family	-
HLG73_RS12390 (HLG73_12540)	-	2516765..2517816 (+)	1052	Protein_2434	GHKL domain-containing protein	-
HLG73_RS12395 (HLG73_12545)	-	2517821..2518627 (+)	807	WP_003567351.1	LytR/AlgR family response regulator transcription factor	-
HLG73_RS12400 (HLG73_12550)	-	2518989..2519186 (-)	198	WP_016370359.1	hypothetical protein	-
HLG73_RS12405 (HLG73_12555)	-	2519733..2519972 (+)	240	WP_003567354.1	hypothetical protein	-
HLG73_RS12410 (HLG73_12560)	-	2520245..2520418 (-)	174	WP_003599800.1	bacteriocin	-
HLG73_RS12415 (HLG73_12565)	-	2520457..2520630 (-)	174	WP_003591780.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81239.37 Da
• Isoelectric Point: 7.2449

>NTDB_id=442958 HLG73_RS12380 WP_273634362.1 2513534..2515726(-) (comA) [Lacticaseibacillus paracasei strain CLP-Y5]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDSSVAMTWLPKERFAKEWSGVAIFIAPESQYQPRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGIIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKISLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLARTDRTIIFVAHRLTIAAKAEQIVVMDHGAIVEQGNHAELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=442958 HLG73_RS12380 WP_273634362.1 2513534..2515726(-) (comA) [Lacticaseibacillus paracasei strain CLP-Y5]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGCTGGCGAAGA
CGGATCAGGAAGGGACGACGGCATTAGGGATTGTCCGCGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTCTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTCGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATTCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAATCGCAATATCAACCACGCAAAGAGGAT
AAAGGCAGTCTCTTTGCGTTTGTGCCGATGCTAGCGCGACAAAAGGGAATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATCATTGCCAGTGGCCTCATCCTCGCTTATGTCCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAGCGTTTGTCGATTGATGTCATTTTGGGTTACGTTAGGCATCTTTATGAATTACCGATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAAATTGTGTCGCGCTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACAATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCCATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACTTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGTTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATAAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTTACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGAGAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGTGTTCCCATC
AGTGATGTTGATCTAACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAAATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGTGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCGAGGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTCACTATTG
CTGCTAAAGCGGAACAGATTGTGGTCATGGATCATGGTGCGATTGTTGAACAAGGAAATCATGCTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGATTGGTAAGCGAGTGA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (510-662)

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	58.496	98.356	0.575
comA	Streptococcus pneumoniae Rx1	57.939	98.356	0.57
comA	Streptococcus pneumoniae D39	57.939	98.356	0.57
comA	Streptococcus pneumoniae R6	57.939	98.356	0.57
comA	Streptococcus mitis SK321	57.799	98.356	0.568
comA	Streptococcus pneumoniae TIGR4	57.521	98.356	0.566
comA	Streptococcus gordonii str. Challis substr. CH1	56.825	98.356	0.559
comA/nlmT	Streptococcus mutans UA159	54.432	98.904	0.538