Detailed information NTG0427261

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: G8B35_RS04510
• Genome accession: NZ_CP049697
• Coordinates: 899109..899945 (-)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain ABC3
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 894109..904945

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B35_RS04490 (G8B35_04495)	-	894327..895319 (-)	993	WP_021299266.1	D-lactate dehydrogenase	-
G8B35_RS04495 (G8B35_04500)	-	895334..895900 (-)	567	Protein_826	PTS sugar transporter subunit IIC	-
G8B35_RS04500 (G8B35_04505)	-	895913..896797 (+)	885	Protein_827	LysR family transcriptional regulator	-
G8B35_RS04505 (G8B35_04510)	topA	896873..899002 (-)	2130	WP_011528644.1	type I DNA topoisomerase	-
G8B35_RS04510 (G8B35_04515)	dprA	899109..899945 (-)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
G8B35_RS04515 (G8B35_04520)	-	900010..900801 (-)	792	WP_011017771.1	ribonuclease HII	-
G8B35_RS04520 (G8B35_04525)	ylqF	900791..901639 (-)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
G8B35_RS04525 (G8B35_04530)	-	901858..902298 (+)	441	WP_011017769.1	DUF1836 domain-containing protein	-
G8B35_RS04530 (G8B35_04535)	-	902295..902945 (+)	651	WP_002984629.1	hemolysin III family protein	-
G8B35_RS04535 (G8B35_04540)	-	903062..903973 (+)	912	WP_011528643.1	diacylglycerol kinase family protein	-
G8B35_RS04540 (G8B35_04545)	-	904023..904457 (-)	435	WP_021299262.1	hypothetical protein	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=427261 G8B35_RS04510 WP_011017772.1 899109..899945(-) (dprA) [Streptococcus pyogenes strain ABC3]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=427261 G8B35_RS04510 WP_011017772.1 899109..899945(-) (dprA) [Streptococcus pyogenes strain ABC3]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367